ID A0A452FNU5_CAPHI Unreviewed; 205 AA.
AC A0A452FNU5;
DT 08-MAY-2019, integrated into UniProtKB/TrEMBL.
DT 08-MAY-2019, sequence version 1.
DT 24-JAN-2024, entry version 24.
DE SubName: Full=Gap junction protein epsilon 1 {ECO:0000313|Ensembl:ENSCHIP00000025942.1};
GN Name=GJE1 {ECO:0000313|Ensembl:ENSCHIP00000025942.1};
OS Capra hircus (Goat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC Caprinae; Capra.
OX NCBI_TaxID=9925 {ECO:0000313|Ensembl:ENSCHIP00000025942.1, ECO:0000313|Proteomes:UP000291000};
RN [1] {ECO:0000313|Ensembl:ENSCHIP00000025942.1, ECO:0000313|Proteomes:UP000291000}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Bickhart D.M., Koren S., Rosen B., Hastie A., Liachko I., Sullivan S.T.,
RA Burton J., Sayre B.L., Huson H.J., Lee J., Lam E., Kelley C.M.,
RA Hutchison J.L., Zhou Y., Sun J., Crisa A., Schwartz J.C., Hammond J.A.,
RA Schroeder S.G., Liu G.E., Dunham M., Shendure J., Sonstegard T.S.,
RA Phillippy A.M., Van Tassell C.P., Smith T.P.;
RT "Polished mammalian reference genomes with single-molecule sequencing and
RT chromosome conformation capture applied to the Capra hircus genome.";
RL Submitted (APR-2016) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSCHIP00000025942.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004651};
CC Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}.
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DR EMBL; LWLT01000012; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_005684962.1; XM_005684905.3.
DR AlphaFoldDB; A0A452FNU5; -.
DR STRING; 9925.ENSCHIP00000025942; -.
DR Ensembl; ENSCHIT00000033804.1; ENSCHIP00000025942.1; ENSCHIG00000022503.1.
DR GeneID; 102190133; -.
DR KEGG; chx:102190133; -.
DR GeneTree; ENSGT01090000260098; -.
DR OMA; WLQIYLF; -.
DR OrthoDB; 5345894at2759; -.
DR Proteomes; UP000291000; Chromosome 9.
DR GO; GO:0005922; C:connexin complex; IEA:InterPro.
DR GO; GO:0007154; P:cell communication; IEA:InterPro.
DR GO; GO:0000902; P:cell morphogenesis; IEA:Ensembl.
DR GO; GO:0002088; P:lens development in camera-type eye; IEA:Ensembl.
DR GO; GO:0035265; P:organ growth; IEA:Ensembl.
DR Gene3D; 1.20.1440.80; Gap junction channel protein cysteine-rich domain; 2.
DR InterPro; IPR000500; Connexin.
DR InterPro; IPR019570; Connexin_CCC.
DR InterPro; IPR013092; Connexin_N.
DR InterPro; IPR038359; Connexin_N_sf.
DR PANTHER; PTHR11984; CONNEXIN; 1.
DR PANTHER; PTHR11984:SF1; GAP JUNCTION EPSILON-1 PROTEIN-RELATED; 1.
DR Pfam; PF00029; Connexin; 2.
DR PRINTS; PR00206; CONNEXIN.
DR SMART; SM01089; Connexin_CCC; 1.
PE 4: Predicted;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000291000};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 21..44
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 75..97
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 109..134
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 171..196
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 125..194
FT /note="Gap junction protein cysteine-rich"
FT /evidence="ECO:0000259|SMART:SM01089"
SQ SEQUENCE 205 AA; 23695 MW; 97C2DFC7C153A420 CRC64;
MSLNYIKNFY EGCMKPPTVI GQFHTLFFGS VRMFFLGVLG FAVYGNEALH FSCDPDKREI
NLFCYNQFRP ITPQVFWALQ LVIVLVPGAI FHLYAACKSI NQECILQKPI YTVIYILSVL
LRISLEVVAF WLQIHLFGFQ VKPLYLCDAV SLGKKFTIIK CMVPEHFEKT IFLIAMYTFT
VITIVLCVAE ICEIIFRRLC FLISQ
//
