ID A0A452FP71_CAPHI Unreviewed; 764 AA.
AC A0A452FP71;
DT 08-MAY-2019, integrated into UniProtKB/TrEMBL.
DT 08-MAY-2019, sequence version 1.
DT 27-MAR-2024, entry version 19.
DE SubName: Full=SEL1L adaptor subunit of ERAD E3 ubiquitin ligase {ECO:0000313|Ensembl:ENSCHIP00000026111.1};
GN Name=SEL1L {ECO:0000313|Ensembl:ENSCHIP00000026111.1};
OS Capra hircus (Goat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC Caprinae; Capra.
OX NCBI_TaxID=9925 {ECO:0000313|Ensembl:ENSCHIP00000026111.1, ECO:0000313|Proteomes:UP000291000};
RN [1] {ECO:0000313|Ensembl:ENSCHIP00000026111.1, ECO:0000313|Proteomes:UP000291000}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Bickhart D.M., Koren S., Rosen B., Hastie A., Liachko I., Sullivan S.T.,
RA Burton J., Sayre B.L., Huson H.J., Lee J., Lam E., Kelley C.M.,
RA Hutchison J.L., Zhou Y., Sun J., Crisa A., Schwartz J.C., Hammond J.A.,
RA Schroeder S.G., Liu G.E., Dunham M., Shendure J., Sonstegard T.S.,
RA Phillippy A.M., Van Tassell C.P., Smith T.P.;
RT "Polished mammalian reference genomes with single-molecule sequencing and
RT chromosome conformation capture applied to the Capra hircus genome.";
RL Submitted (APR-2016) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSCHIP00000026111.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the sel-1 family.
CC {ECO:0000256|ARBA:ARBA00038101}.
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DR EMBL; LWLT01000010; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; A0A452FP71; -.
DR Ensembl; ENSCHIT00000033973.1; ENSCHIP00000026111.1; ENSCHIG00000022570.1.
DR GeneTree; ENSGT00940000156671; -.
DR OMA; DMLAKPR; -.
DR Proteomes; UP000291000; Chromosome 10.
DR Bgee; ENSCHIG00000022570; Expressed in liver and 17 other cell types or tissues.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR CDD; cd00062; FN2; 1.
DR Gene3D; 2.10.10.10; Fibronectin, type II, collagen-binding; 1.
DR Gene3D; 1.25.40.10; Tetratricopeptide repeat domain; 3.
DR InterPro; IPR000562; FN_type2_dom.
DR InterPro; IPR036943; FN_type2_sf.
DR InterPro; IPR013806; Kringle-like.
DR InterPro; IPR006597; Sel1-like.
DR InterPro; IPR011990; TPR-like_helical_dom_sf.
DR PANTHER; PTHR11102:SF70; PROTEIN SEL-1 HOMOLOG 1; 1.
DR PANTHER; PTHR11102; SEL-1-LIKE PROTEIN; 1.
DR Pfam; PF00040; fn2; 1.
DR Pfam; PF08238; Sel1; 10.
DR PRINTS; PR00013; FNTYPEII.
DR SMART; SM00059; FN2; 1.
DR SMART; SM00671; SEL1; 10.
DR SUPFAM; SSF81901; HCP-like; 3.
DR SUPFAM; SSF57440; Kringle-like; 1.
DR PROSITE; PS00023; FN2_1; 1.
DR PROSITE; PS51092; FN2_2; 1.
PE 3: Inferred from homology;
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157, ECO:0000256|PROSITE-
KW ProRule:PRU00479}; Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000291000};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 713..731
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 98..146
FT /note="Fibronectin type-II"
FT /evidence="ECO:0000259|PROSITE:PS51092"
FT REGION 1..78
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 737..764
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 740..764
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT DISULFID 103..129
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00479"
FT DISULFID 117..144
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00479"
SQ SEQUENCE 764 AA; 85310 MW; 24BC96E26FF68EB6 CRC64;
EEGNQDESID SKTSVPSDES VENHSPAGRV IAGQIFLDSE ESELESPPQE DEDNLRSQEG
ESIAEEISFL ESPNPENKDY EELTKVRKPA LTAIEGTAHG EPCHFPFLFL DKEYDECTSD
GREDGRLWCA TTYDYKADEK WGFCETEEEA AKRRQMQEAE MMYQTGMKIL NGSNKKSQKR
EAYRYLQKAA SMNHTKALER VSYALLFGDY LTQNIQAAKE MFEKLTEEGS PKGQTALGFL
YASGLGVNSS QAKALVYYTF GALGGNLIAH MVLGTSHCGA TPLTFVPCCF VPVSVASDIS
LTGGSVVQRI RLPDEVENPG MNSGMLEEDL IQYYQFLAEK GDVQAQVGLG QLHLHGGRGV
EQNHQRAFDY FNLAANAGNS HAMAFLGKMY SEGSDIVPQS NETALHYFKK AADMGNPVGQ
SGLGMAYLYG RGVQVNYDLA LKYFQKAAEQ GWVDGQLQLG SMYYNGIGVK RDYKQALKYF
NLASQGGHIL AFYNLAQMHA SGTGVMRSCH TAVELFKNVC ERGRWSERLM TAYNSYKDGD
YNAAVIQYLL LAEQGYEVAQ SNAAFILDQR EATIVGENET YPRALLHWNR AASQGYTVAR
IKLGDYHFYG FGTDVDYETA FIHYRLASEQ QHSAQAMFNL GYMHEKGLGI KQDIHLAKRF
YDMAAEASPD AQVPVFLALC KLGVVYFLQY IRETNIRDIF TQLDMDQLLG PEWDLYLMTI
IALLLGTVIA YRQRQHQDMP VPRPPGPRPA PPQQEGPPEQ PPPQ
//
