ID A0A452FPM0_CAPHI Unreviewed; 401 AA.
AC A0A452FPM0;
DT 08-MAY-2019, integrated into UniProtKB/TrEMBL.
DT 08-MAY-2019, sequence version 1.
DT 27-MAR-2024, entry version 19.
DE SubName: Full=NIPA like domain containing 1 {ECO:0000313|Ensembl:ENSCHIP00000026271.1};
GN Name=NIPAL1 {ECO:0000313|Ensembl:ENSCHIP00000026271.1};
OS Capra hircus (Goat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC Caprinae; Capra.
OX NCBI_TaxID=9925 {ECO:0000313|Ensembl:ENSCHIP00000026271.1, ECO:0000313|Proteomes:UP000291000};
RN [1] {ECO:0000313|Ensembl:ENSCHIP00000026271.1, ECO:0000313|Proteomes:UP000291000}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Bickhart D.M., Koren S., Rosen B., Hastie A., Liachko I., Sullivan S.T.,
RA Burton J., Sayre B.L., Huson H.J., Lee J., Lam E., Kelley C.M.,
RA Hutchison J.L., Zhou Y., Sun J., Crisa A., Schwartz J.C., Hammond J.A.,
RA Schroeder S.G., Liu G.E., Dunham M., Shendure J., Sonstegard T.S.,
RA Phillippy A.M., Van Tassell C.P., Smith T.P.;
RT "Polished mammalian reference genomes with single-molecule sequencing and
RT chromosome conformation capture applied to the Capra hircus genome.";
RL Submitted (APR-2016) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSCHIP00000026271.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the NIPA family.
CC {ECO:0000256|ARBA:ARBA00007230}.
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DR EMBL; LWLT01000006; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; A0A452FPM0; -.
DR STRING; 9925.ENSCHIP00000026271; -.
DR Ensembl; ENSCHIT00000034134.1; ENSCHIP00000026271.1; ENSCHIG00000022683.1.
DR GeneTree; ENSGT00940000160022; -.
DR OMA; CMGVGEA; -.
DR Proteomes; UP000291000; Chromosome 6.
DR Bgee; ENSCHIG00000022683; Expressed in descending colon and 14 other cell types or tissues.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0015095; F:magnesium ion transmembrane transporter activity; IEA:InterPro.
DR InterPro; IPR008521; Mg_trans_NIPA.
DR PANTHER; PTHR12570:SF13; MAGNESIUM TRANSPORTER NIPA3; 1.
DR PANTHER; PTHR12570; UNCHARACTERIZED; 1.
DR Pfam; PF05653; Mg_trans_NIPA; 1.
DR SUPFAM; SSF103481; Multidrug resistance efflux transporter EmrE; 1.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000291000};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 55..77
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 104..125
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 131..150
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 157..176
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 196..218
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 225..243
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 263..282
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 294..315
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 327..346
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
SQ SEQUENCE 401 AA; 43633 MW; D03C495E5FB93FF7 CRC64;
SRLFTTEPPG DCPNASQAWC EITRVSQLLA SPVLYRDLNS SITNLSVSTN TENKYSLYIG
LVLAISSSIF IGSSFILKKK GLLQLAKKGV TRAGQGGHSY LKEWLWWAGL LSMGAGEVVN
FAAYAFAPAT LVTSLGALSV LVSAILSSYF LNEQLNIHGK IGCILSILGS TVMVIHAPQE
EKVATLHEME MKLRDPGFIC FAVIITVISL VLILIVAPKK GQTNILVYIS ICSLIGAFSV
SSVKGLGIAI KELLEWKPVY KHPLVFVLLA VLVLSVTTQI NYLNKALDTF NTSLVTPIYY
VLFTSMVVTC SAILFQEWYG MNAGDVIGTL SGFFTIINGI FLLHAFKNIN ITWSDLTSTT
QKEVLSANGS EDKYVLLENT DCSVPGFDDD ITLYSRTGQN P
//
