ID A0A452FQ65_CAPHI Unreviewed; 738 AA.
AC A0A452FQ65;
DT 08-MAY-2019, integrated into UniProtKB/TrEMBL.
DT 08-MAY-2019, sequence version 1.
DT 24-JAN-2024, entry version 24.
DE SubName: Full=SIX homeobox 5 {ECO:0000313|Ensembl:ENSCHIP00000026476.1};
GN Name=SIX5 {ECO:0000313|Ensembl:ENSCHIP00000026476.1};
OS Capra hircus (Goat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC Caprinae; Capra.
OX NCBI_TaxID=9925 {ECO:0000313|Ensembl:ENSCHIP00000026476.1, ECO:0000313|Proteomes:UP000291000};
RN [1] {ECO:0000313|Ensembl:ENSCHIP00000026476.1, ECO:0000313|Proteomes:UP000291000}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Bickhart D.M., Koren S., Rosen B., Hastie A., Liachko I., Sullivan S.T.,
RA Burton J., Sayre B.L., Huson H.J., Lee J., Lam E., Kelley C.M.,
RA Hutchison J.L., Zhou Y., Sun J., Crisa A., Schwartz J.C., Hammond J.A.,
RA Schroeder S.G., Liu G.E., Dunham M., Shendure J., Sonstegard T.S.,
RA Phillippy A.M., Van Tassell C.P., Smith T.P.;
RT "Polished mammalian reference genomes with single-molecule sequencing and
RT chromosome conformation capture applied to the Capra hircus genome.";
RL Submitted (APR-2016) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSCHIP00000026476.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|PROSITE-ProRule:PRU00108,
CC ECO:0000256|RuleBase:RU000682}.
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DR EMBL; LWLT01000020; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_017918113.1; XM_018062624.1.
DR AlphaFoldDB; A0A452FQ65; -.
DR STRING; 9925.ENSCHIP00000026476; -.
DR Ensembl; ENSCHIT00000034339.1; ENSCHIP00000026476.1; ENSCHIG00000022800.1.
DR GeneID; 102190256; -.
DR KEGG; chx:102190256; -.
DR CTD; 147912; -.
DR GeneTree; ENSGT00940000162237; -.
DR OrthoDB; 5265771at2759; -.
DR Proteomes; UP000291000; Chromosome 18.
DR Bgee; ENSCHIG00000022800; Expressed in testis and 17 other cell types or tissues.
DR GO; GO:0005829; C:cytosol; IEA:Ensembl.
DR GO; GO:0005794; C:Golgi apparatus; IEA:Ensembl.
DR GO; GO:0005654; C:nucleoplasm; IEA:Ensembl.
DR GO; GO:0001228; F:DNA-binding transcription activator activity, RNA polymerase II-specific; IEA:Ensembl.
DR GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IEA:Ensembl.
DR GO; GO:0002088; P:lens development in camera-type eye; IEA:Ensembl.
DR GO; GO:0160024; P:Leydig cell proliferation; IEA:Ensembl.
DR GO; GO:0045892; P:negative regulation of DNA-templated transcription; IEA:Ensembl.
DR GO; GO:1902723; P:negative regulation of skeletal muscle satellite cell proliferation; IEA:Ensembl.
DR GO; GO:0007286; P:spermatid development; IEA:Ensembl.
DR CDD; cd00086; homeodomain; 1.
DR Gene3D; 1.10.10.60; Homeodomain-like; 1.
DR InterPro; IPR009057; Homeobox-like_sf.
DR InterPro; IPR017970; Homeobox_CS.
DR InterPro; IPR001356; Homeobox_dom.
DR InterPro; IPR031701; SIX1_SD.
DR PANTHER; PTHR10390; HOMEOBOX PROTEIN SIX; 1.
DR PANTHER; PTHR10390:SF40; HOMEOBOX PROTEIN SIX5; 1.
DR Pfam; PF00046; Homeodomain; 1.
DR Pfam; PF16878; SIX1_SD; 1.
DR SMART; SM00389; HOX; 1.
DR SUPFAM; SSF46689; Homeodomain-like; 1.
DR PROSITE; PS00027; HOMEOBOX_1; 1.
DR PROSITE; PS50071; HOMEOBOX_2; 1.
PE 4: Predicted;
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125, ECO:0000256|PROSITE-
KW ProRule:PRU00108};
KW Homeobox {ECO:0000256|ARBA:ARBA00023155, ECO:0000256|PROSITE-
KW ProRule:PRU00108};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242, ECO:0000256|PROSITE-
KW ProRule:PRU00108}; Reference proteome {ECO:0000313|Proteomes:UP000291000}.
FT DOMAIN 208..259
FT /note="Homeobox"
FT /evidence="ECO:0000259|PROSITE:PS50071"
FT DNA_BIND 210..260
FT /note="Homeobox"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00108"
FT REGION 1..81
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 248..305
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 361..440
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 614..646
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 272..286
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 416..440
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 616..633
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 738 AA; 75110 MW; 377376E0C38F8D8A CRC64;
MATLPAEPSA RPAAGGEAVV AAAATEEEEE EARQLLQTLQ AAEGEAAAAA GAGAGETAVK
VEGPGSPGVP GSPPEAAAEP PMGLRFSPEQ VACVCEALLQ AGHAGRLSRF LGALPPAERL
RGSDPVLRAR ALVAFQRGEY AELYRLLESR PFPAAHHAFL QDLYLRARYH EAERARGRAL
GAVDKYRLRK KFPLPKTIWD GEETVYCFKE RSRAALKACY RGNRYPTPDE KRRLATLTGL
SLTQVSNWFK NRRQRDRTGG GGGAPCKSES DGNPTTEDES SRSPEDLERG AAPAAAEGPA
PGSIFLAGAS PPAPCPASSS ILVNGSFLAA GSSPAVLLNG SPVIINSLAL GEASGLGPLL
LTGGAPAPQP SPQGPSEGKT SLVLDPQTGE VRLEEAQPEA PETKGAQVTA SGPPGEEVPT
PLPQVVPGPP TAATFPLPPG PVTSMAAPQV VPLSPPPGYP AGLGPTSPLL NLPQVVPTSQ
VVTLPQAVGP LQLLAAGPGS PVKVAGASGP ANVHLINSGV GVTALQLPSA TTPGNFLLAN
SVSGSPIVTG VAVQQGKIIL TATFPTSMLV SQVLPPAPSL ALPLKPDTAI SVPEGALPVA
TSPALPEAHA LGALPVQQPP QPPPTPATPT PSLPFSPDSS GLLPGFPAPP TEGLLLSPAA
VPIWPAGLEL SASTEGLLEE EKGLGTQAPH TVLRLPDPDP EGLLLGATAG GEVDEGLEAE
TKVLTQLQSV PVEEPLEL
//
