ID A0A452FQA8_CAPHI Unreviewed; 805 AA.
AC A0A452FQA8;
DT 08-MAY-2019, integrated into UniProtKB/TrEMBL.
DT 08-MAY-2019, sequence version 1.
DT 24-JAN-2024, entry version 19.
DE SubName: Full=Rho GTPase activating protein 6 {ECO:0000313|Ensembl:ENSCHIP00000026521.1};
GN Name=ARHGAP6 {ECO:0000313|Ensembl:ENSCHIP00000026521.1};
OS Capra hircus (Goat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC Caprinae; Capra.
OX NCBI_TaxID=9925 {ECO:0000313|Ensembl:ENSCHIP00000026521.1, ECO:0000313|Proteomes:UP000291000};
RN [1] {ECO:0000313|Proteomes:UP000291000}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Bickhart D.M., Koren S., Rosen B., Hastie A., Liachko I., Sullivan S.T.,
RA Burton J., Sayre B.L., Huson H.J., Lee J., Lam E., Kelley C.M.,
RA Hutchison J.L., Zhou Y., Sun J., Crisa A., Schwartz J.C., Hammond J.A.,
RA Schroeder S.G., Liu G.E., Dunham M., Shendure J., Sonstegard T.S.,
RA Phillippy A.M., Van Tassell C.P., Smith T.P.;
RT "Polished mammalian reference genomes with single-molecule sequencing and
RT chromosome conformation capture applied to the Capra hircus genome.";
RL Submitted (APR-2016) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSCHIP00000026521.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
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DR RefSeq; XP_017899273.1; XM_018043784.1.
DR AlphaFoldDB; A0A452FQA8; -.
DR STRING; 9925.ENSCHIP00000026521; -.
DR Ensembl; ENSCHIT00000034386.1; ENSCHIP00000026521.1; ENSCHIG00000022831.1.
DR GeneID; 102174105; -.
DR CTD; 395; -.
DR GeneTree; ENSGT00940000153904; -.
DR OrthoDB; 5482290at2759; -.
DR Proteomes; UP000291000; Unassembled WGS sequence.
DR Bgee; ENSCHIG00000022831; Expressed in longissimus thoracis muscle and 16 other cell types or tissues.
DR GO; GO:0015629; C:actin cytoskeleton; IEA:Ensembl.
DR GO; GO:0005829; C:cytosol; IEA:Ensembl.
DR GO; GO:0005096; F:GTPase activator activity; IEA:Ensembl.
DR GO; GO:0007015; P:actin filament organization; IEA:Ensembl.
DR GO; GO:0048041; P:focal adhesion assembly; IEA:Ensembl.
DR GO; GO:0051895; P:negative regulation of focal adhesion assembly; IEA:Ensembl.
DR GO; GO:0051497; P:negative regulation of stress fiber assembly; IEA:Ensembl.
DR GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR CDD; cd04376; RhoGAP_ARHGAP6; 1.
DR Gene3D; 1.10.555.10; Rho GTPase activation protein; 1.
DR InterPro; IPR041852; ARHGAP6_RhoGAP.
DR InterPro; IPR008936; Rho_GTPase_activation_prot.
DR InterPro; IPR037863; RHOGAP6/36.
DR InterPro; IPR000198; RhoGAP_dom.
DR PANTHER; PTHR12635:SF6; RHO GTPASE-ACTIVATING PROTEIN 6; 1.
DR PANTHER; PTHR12635; RHO-GTPASE-ACTIVATING PROTEIN 6 FAMILY MEMBER; 1.
DR Pfam; PF00620; RhoGAP; 1.
DR SMART; SM00324; RhoGAP; 1.
DR SUPFAM; SSF48350; GTPase activation domain, GAP; 1.
DR PROSITE; PS50238; RHOGAP; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000291000}.
FT DOMAIN 220..421
FT /note="Rho-GAP"
FT /evidence="ECO:0000259|PROSITE:PS50238"
FT REGION 141..180
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 457..493
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 510..545
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 602..778
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 141..170
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 602..627
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 734..776
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 805 AA; 89259 MW; EF29392D12086FCD CRC64;
MGDPVNREKP QLHYAGDFTW NSMSGRSVRL RSVPIQSLSE LERARLQEVA FYQLQQDCDL
SCQITIPKDG QKRKKSLRKK LDSLGKEKNK DREFIPQAFG MPLSQVIAND RAYKLKQDSQ
RDEHKDASDF VASLLPFGNK RQNKELSSSN SSLSSTSETP NESTSPNTPE PAPRARRRGA
MSVDSITDLD DNQSRLLEAL QLSLPAEAQN KKEKARDKKL SLNPIYRQVP RLVDSCCQHL
EKHGLQTVGI FRVGSSKKRV RQLREEFDRG VDVSLEEEHS VHDVAALLKE FLRDMPDPLL
TRELYTAFIN TLLLEPEEQL GTLQLLIYLL PPCNCDTLHR LLQFLSIVAR HAEDNVSKDG
QEVTGNKMTS LNLATIFGPN LLHKQKSSDK EFSVQSSARA EESTAIIAVV QKMIENYEAL
FMVPPDLQNE VLISLLETDP DVVDYLLRRK ASQSSSPDML RSEVSFSMGG RHSSTDSNKA
SSGDLSPYDN NSPVLSERSL LAMQEDVVPG GSEKLYKGPE PCVRRVGHLP SSKSRESSPG
PRLGKDMAEE AFNIWGTWHS TLKSGSKDPG MTGSYGDIFE SSSLRPGPCS LSQGNLSLNW
PRWQGSPTEL DSSAQAIRRT QTTSPAAEAR AHAPVARVCS TPHIQGGGQP TPRPRPEPCW
TLSSAEDLAE SEPEGAWLQR RAKPLPQRPA EGARPDKRPP PPYPGPGKST VASPAHQAAE
PPLWRPRRLE EGSGTASQEG SQAVEPQRGH QAAQQKASSA YPSPAGDQNS KTLGEPNWLD
WQRERWQIWE LLSTDNPDAL PETLV
//
