ID A0A452FQB3_CAPHI Unreviewed; 804 AA.
AC A0A452FQB3;
DT 08-MAY-2019, integrated into UniProtKB/TrEMBL.
DT 08-MAY-2019, sequence version 1.
DT 27-MAR-2024, entry version 27.
DE SubName: Full=Transmembrane protein 63C {ECO:0000313|Ensembl:ENSCHIP00000026503.1};
GN Name=TMEM63C {ECO:0000313|Ensembl:ENSCHIP00000026503.1};
OS Capra hircus (Goat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC Caprinae; Capra.
OX NCBI_TaxID=9925 {ECO:0000313|Ensembl:ENSCHIP00000026503.1, ECO:0000313|Proteomes:UP000291000};
RN [1] {ECO:0000313|Ensembl:ENSCHIP00000026503.1, ECO:0000313|Proteomes:UP000291000}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Bickhart D.M., Koren S., Rosen B., Hastie A., Liachko I., Sullivan S.T.,
RA Burton J., Sayre B.L., Huson H.J., Lee J., Lam E., Kelley C.M.,
RA Hutchison J.L., Zhou Y., Sun J., Crisa A., Schwartz J.C., Hammond J.A.,
RA Schroeder S.G., Liu G.E., Dunham M., Shendure J., Sonstegard T.S.,
RA Phillippy A.M., Van Tassell C.P., Smith T.P.;
RT "Polished mammalian reference genomes with single-molecule sequencing and
RT chromosome conformation capture applied to the Capra hircus genome.";
RL Submitted (APR-2016) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSCHIP00000026503.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the CSC1 (TC 1.A.17) family.
CC {ECO:0000256|ARBA:ARBA00007779}.
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DR EMBL; LWLT01000010; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_017909409.1; XM_018053920.1.
DR RefSeq; XP_017909410.1; XM_018053921.1.
DR RefSeq; XP_017909411.1; XM_018053922.1.
DR AlphaFoldDB; A0A452FQB3; -.
DR STRING; 9925.ENSCHIP00000026503; -.
DR Ensembl; ENSCHIT00000034367.1; ENSCHIP00000026503.1; ENSCHIG00000022815.1.
DR GeneID; 102169109; -.
DR KEGG; chx:102169109; -.
DR CTD; 57156; -.
DR GeneTree; ENSGT00940000159072; -.
DR OMA; QGIGMFP; -.
DR OrthoDB; 231434at2759; -.
DR Proteomes; UP000291000; Chromosome 10.
DR Bgee; ENSCHIG00000022815; Expressed in cerebellum and 4 other cell types or tissues.
DR GO; GO:0005886; C:plasma membrane; IEA:Ensembl.
DR GO; GO:0005227; F:calcium-activated cation channel activity; IEA:Ensembl.
DR GO; GO:1990760; F:osmolarity-sensing monoatomic cation channel activity; IEA:Ensembl.
DR InterPro; IPR045122; Csc1-like.
DR InterPro; IPR003864; CSC1/OSCA1-like_7TM.
DR InterPro; IPR027815; CSC1/OSCA1-like_cyt.
DR InterPro; IPR032880; Csc1/OSCA1-like_N.
DR PANTHER; PTHR13018:SF21; CALCIUM PERMEABLE STRESS-GATED CATION CHANNEL 1; 1.
DR PANTHER; PTHR13018; PROBABLE MEMBRANE PROTEIN DUF221-RELATED; 1.
DR Pfam; PF14703; PHM7_cyt; 1.
DR Pfam; PF02714; RSN1_7TM; 1.
DR Pfam; PF13967; RSN1_TM; 1.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000291000};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00022448}.
FT TRANSMEM 35..59
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 139..159
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 184..204
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 406..430
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 450..473
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 494..521
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 602..630
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 651..673
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 685..706
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 41..204
FT /note="CSC1/OSCA1-like N-terminal transmembrane"
FT /evidence="ECO:0000259|Pfam:PF13967"
FT DOMAIN 220..398
FT /note="CSC1/OSCA1-like cytosolic"
FT /evidence="ECO:0000259|Pfam:PF14703"
FT DOMAIN 409..665
FT /note="CSC1/OSCA1-like 7TM region"
FT /evidence="ECO:0000259|Pfam:PF02714"
FT REGION 751..804
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 751..767
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 769..792
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 804 AA; 93486 MW; BBC80437364C619C CRC64;
MTVLPNNLNM LGKSRNFTVD DCFNSRNTVL KGQPFGGIPT VLFLNIILWV VIVLVYSFLR
KAAWDYGRLA LLIHNDSLTS LVYGEQSEKT SPSDISLEME HRDKGFYSWF FNTITMKNED
LISRCGDDAR IYIMFQYHLI IFILILCIPS LGIILPINYT GDVLDRDSHF GRTTIVNVST
ESKFLWLHSI FAFLYFVTNL LFMTHHCLGF VPRKSYAVTR TLMITYVPTD IQDPEIIIKH
FHEAYPGCVV TRVHFCYDVR TLIDLDDQRR HAMRGRLYYT AKAKKKGKVM IKVHPCSRLC
FCRCWACFKE VDAEQYYSEL EEQLTDEFNA ELNRARLKRL DLIFVTFQDS RMTKHILQDY
KFIHCGMSPK ESSVSTIVKS YHWRIVRAPH PRDIIWKHLS VRRFHWWARF IAINTFLFFL
FFFLTTPAII MNTIDLYNVT RPIENLQSPI VTQFFPSVLL WAFTVTMPLI VYLSAFLEAH
WTRTSQNLFI VHKCYVFLVF MVVILPSMGL TSLDVFLHWL FDIYYLEQAS IRFQCVFLPD
NGAFFVNYVI TAAFIGTGME LMRLGSLFLY TIRLVFSRSE PERVNIRMNQ AMDFQYGREY
AWMMNVFSVV MAYSITCPII VPFGLLYLCM KHITDRYNMY YSYAPTKLNE QIHMAAIHQA
IFAPLLGLVW MLFFSVLRLG SQHAITIFSL TTLIVSIIMV CVTTFLGKMS KMTNYEPEEM
ETVFDLEPSS TSSTPTSLLY VATVLQEPEM NLTPASSPAQ PTYGTMSRQP EEGEEESGVR
AFSRELDSAR FQEGMELGDQ SQYH
//
