ID A0A452FQE2_CAPHI Unreviewed; 1922 AA.
AC A0A452FQE2;
DT 08-MAY-2019, integrated into UniProtKB/TrEMBL.
DT 08-MAY-2019, sequence version 1.
DT 24-JAN-2024, entry version 19.
DE SubName: Full=DENN domain containing 4C {ECO:0000313|Ensembl:ENSCHIP00000026509.1};
GN Name=DENND4C {ECO:0000313|Ensembl:ENSCHIP00000026509.1};
OS Capra hircus (Goat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC Caprinae; Capra.
OX NCBI_TaxID=9925 {ECO:0000313|Ensembl:ENSCHIP00000026509.1, ECO:0000313|Proteomes:UP000291000};
RN [1] {ECO:0000313|Ensembl:ENSCHIP00000026509.1, ECO:0000313|Proteomes:UP000291000}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Bickhart D.M., Koren S., Rosen B., Hastie A., Liachko I., Sullivan S.T.,
RA Burton J., Sayre B.L., Huson H.J., Lee J., Lam E., Kelley C.M.,
RA Hutchison J.L., Zhou Y., Sun J., Crisa A., Schwartz J.C., Hammond J.A.,
RA Schroeder S.G., Liu G.E., Dunham M., Shendure J., Sonstegard T.S.,
RA Phillippy A.M., Van Tassell C.P., Smith T.P.;
RT "Polished mammalian reference genomes with single-molecule sequencing and
RT chromosome conformation capture applied to the Capra hircus genome.";
RL Submitted (APR-2016) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSCHIP00000026509.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
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DR EMBL; LWLT01000007; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR Ensembl; ENSCHIT00000034374.1; ENSCHIP00000026509.1; ENSCHIG00000022814.1.
DR GeneTree; ENSGT00940000158215; -.
DR Proteomes; UP000291000; Chromosome 8.
DR Bgee; ENSCHIG00000022814; Expressed in testis and 17 other cell types or tissues.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProt.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:UniProtKB-KW.
DR Gene3D; 2.100.10.50; -; 1.
DR Gene3D; 3.40.50.11500; -; 1.
DR Gene3D; 1.25.40.10; Tetratricopeptide repeat domain; 1.
DR InterPro; IPR001194; cDENN_dom.
DR InterPro; IPR005112; dDENN_dom.
DR InterPro; IPR043153; DENN_C.
DR InterPro; IPR023341; MABP.
DR InterPro; IPR011990; TPR-like_helical_dom_sf.
DR InterPro; IPR037516; Tripartite_DENN.
DR InterPro; IPR005113; uDENN_dom.
DR PANTHER; PTHR12296; DENN DOMAIN-CONTAINING PROTEIN 4; 1.
DR PANTHER; PTHR12296:SF17; DENN DOMAIN-CONTAINING PROTEIN 4C; 1.
DR Pfam; PF03455; dDENN; 1.
DR Pfam; PF02141; DENN; 1.
DR Pfam; PF03456; uDENN; 1.
DR SMART; SM00801; dDENN; 1.
DR SMART; SM00799; DENN; 1.
DR SMART; SM00800; uDENN; 1.
DR PROSITE; PS50211; DENN; 1.
DR PROSITE; PS51498; MABP; 1.
PE 4: Predicted;
KW Guanine-nucleotide releasing factor {ECO:0000256|ARBA:ARBA00022658};
KW Reference proteome {ECO:0000313|Proteomes:UP000291000}.
FT DOMAIN 40..199
FT /note="MABP"
FT /evidence="ECO:0000259|PROSITE:PS51498"
FT DOMAIN 191..640
FT /note="UDENN"
FT /evidence="ECO:0000259|PROSITE:PS50211"
FT REGION 902..938
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1006..1026
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1195..1219
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1285..1381
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1496..1515
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1201..1218
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1330..1381
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1922 AA; 212846 MW; B4DCAA8B463F0FA0 CRC64;
MIENKGPRVV DYFVVAGLTD TSTLLDQEIN RLDTKSTGPK APITDIAVIN KSAGETVPEG
YTCVEATPSG LQANLNYGSL KSPELFLCYK RGREKPPLTD IGVLYDGKER LIPGCEVIQA
TPYGRCANVN NSSTTSQRIF ITYRRAPLIR PQNSLAVTDI CVIVTSKGET PPHTFCKVDK
NLNCGMWGSS VFLCYKKSVP ASNAIAYKAG LIFRYPEEDY ESFPLSECVP LFCLPMGATI
ECWDPQSKYP LPVFSTFVLT ASSAEKVYGA AIQFYEPYSR ELLTEKQLMQ LGLLTPVERK
MVSKSINSNK CICLLSHWPF FEAFRKFLMF IYKLSVSGPH PLPIEKHISH FMQNIPFPSP
QRPRILVQLS VHDALILSQP VSTPLPLSGA NFSTLLMNLG PENCATLLLF VLLESKILLH
SLRPAVLTGV AEAVVAMIFP FQWQCPYIPL CPLSLAAVLS APLPFIVGVD SRYFDLHDPP
QDVVCIDLDT NMLYLSDEKK NMNWKQLPKK PCKNLISTLK KLYPQLFSVH RKTQEGSAIE
MTPIEADFSW QKKMTQLEME IQEAFLRFMA SILKGYRTYL RPITEAPSNK ATAADSLFDR
QGFLKSRDRA YTKFYTLLSK TQIFIRFIEE CSFVSDKDTG LAFFDDCIEK LFPDKGTEKT
DKVDFDSAED TKLIELDDSQ KSEHTVFIMP PEPPPDDGKD LSPKYSYKYF PRLDLKLFDR
PQELKLCFSR HPTGSSITNS PALMAKRTKQ EIKTAHKLAK RCYTNPPQWA KCLFSHCYSL
WFICLPAYVR VSHPKVRALQ QAYDVLIKMR KTDVDPLDEV CYRVVMQLCG LWGHPVLAVR
VLFEMKTAKI KPNAITYGYY NKVVLESPWP SSTRSGIFLW TKVRNVVRGL AQFRQPLKNT
VQKSQVSSIS APQNATGGSD GDTVSHGSVD SSNDANSGEH TVFVRDLIRL DSTDNHSSTG
GQSDQGYGSK DELLKDDAEI HVPEEQMSGD LITKTEEVCN VSAVVAKHSQ PSAEPQSPAE
PPAWGSSIVK VPSGIFDINS RKSSTGSTSN VLFSSQDPVE DGVFGEVINL KKNGDRGEKR
QKHFPERSCS FSSESRAGML LKKSSLDLNS SEVAIMMGAD AKILTALTSP KTSPLHNARA
HSFGSISCHP ADTRTRVSES TWDSEHRSSV LEMLEESQEL MEPGVDENVA KATVTKDTCD
SLQNDSDRSR DSKTGSRDLA NKRNSLYGVA KAVEREDVET GLDPLSLLAT ECIGEKTDSE
EKLFSPVIAR NLADEIESYM NLKSPLGSKS TSMELHGEGS RESGASGAFV PSLERRSSLP
LDHGPPAQDS PESEQGSPAV SRSKTLTGRL KQQTPSRSPK ERSTSLSALV RSSPHGSLGS
VVNSLSGLKL DNILSGPKMD VLKSGMKQAA TVASKMWVAV SSAYSYSDDE EETNRDYSFP
AGLEDHILGE NISPNMSISG LVPSELTQSN TSLGSSSSSG DVGKLHYSPG ELPFPRGIKG
QEFEKSDHGS SPNTSMSSIY QNCAMEVLMS SCSQCRVCGA LVYDEEIMAG WTADDSNLNT
ACPFCKSNFL PLLNIEFKDL RGSASFFLKP STSGDSLQSG SIPLASEPLE HKPISSSAEP
DLINFMDLPK HNQTITEETS SAVESSDEIM KASGDVQTMK VSPVPNSLSK RNVSLTRSHS
VGGPLQNMDF SQRPFHGIST VSLPNSLQEF VDPLGKRPNP PPVSVPYLSP LVLRKELESL
LENEGDQVIH TSSFINQHPI IFWNLVWYFR RLDLPSNLPG LILTSEHCNG GVQLPLSSLS
QDSKLVYIQL LWDNINLHQE PGEPLYVAWR NFNSEKKSSL LSEEQQATST LVEIIRQSIQ
QNDVLKPINL LSQQMKGDGK RQRSLYREIL FLSLVSLGRE NIDIVIMQMT ESQLITISRW
YS
//
