ID A0A452FRC9_CAPHI Unreviewed; 642 AA.
AC A0A452FRC9;
DT 08-MAY-2019, integrated into UniProtKB/TrEMBL.
DT 08-MAY-2019, sequence version 1.
DT 27-MAR-2024, entry version 22.
DE RecName: Full=Heat shock 70 kDa protein 1-like {ECO:0000256|ARBA:ARBA00039593};
GN Name=HSPA1L {ECO:0000313|Ensembl:ENSCHIP00000026835.1};
OS Capra hircus (Goat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC Caprinae; Capra.
OX NCBI_TaxID=9925 {ECO:0000313|Ensembl:ENSCHIP00000026835.1, ECO:0000313|Proteomes:UP000291000};
RN [1] {ECO:0000313|Ensembl:ENSCHIP00000026835.1, ECO:0000313|Proteomes:UP000291000}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Bickhart D.M., Koren S., Rosen B., Hastie A., Liachko I., Sullivan S.T.,
RA Burton J., Sayre B.L., Huson H.J., Lee J., Lam E., Kelley C.M.,
RA Hutchison J.L., Zhou Y., Sun J., Crisa A., Schwartz J.C., Hammond J.A.,
RA Schroeder S.G., Liu G.E., Dunham M., Shendure J., Sonstegard T.S.,
RA Phillippy A.M., Van Tassell C.P., Smith T.P.;
RT "Polished mammalian reference genomes with single-molecule sequencing and
RT chromosome conformation capture applied to the Capra hircus genome.";
RL Submitted (APR-2016) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSCHIP00000026835.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SUBUNIT: Interacts with PRKN. {ECO:0000256|ARBA:ARBA00038626}.
CC -!- SIMILARITY: Belongs to the heat shock protein 70 family.
CC {ECO:0000256|ARBA:ARBA00007381, ECO:0000256|RuleBase:RU003322}.
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DR EMBL; LWLT01000028; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; A0A452FRC9; -.
DR STRING; 9925.ENSCHIP00000026835; -.
DR Ensembl; ENSCHIT00000034701.1; ENSCHIP00000026835.1; ENSCHIG00000022996.1.
DR GeneTree; ENSGT00940000162096; -.
DR OMA; YAYHMKS; -.
DR Proteomes; UP000291000; Chromosome 23.
DR Bgee; ENSCHIG00000022996; Expressed in adult mammalian kidney and 16 other cell types or tissues.
DR GO; GO:0044297; C:cell body; IEA:Ensembl.
DR GO; GO:0008180; C:COP9 signalosome; IEA:Ensembl.
DR GO; GO:0005829; C:cytosol; IEA:Ensembl.
DR GO; GO:0002199; C:zona pellucida receptor complex; IEA:Ensembl.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0140662; F:ATP-dependent protein folding chaperone; IEA:InterPro.
DR GO; GO:0031072; F:heat shock protein binding; IEA:Ensembl.
DR GO; GO:0031625; F:ubiquitin protein ligase binding; IEA:Ensembl.
DR GO; GO:0051082; F:unfolded protein binding; IEA:Ensembl.
DR GO; GO:0007339; P:binding of sperm to zona pellucida; IEA:Ensembl.
DR GO; GO:1903955; P:positive regulation of protein targeting to mitochondrion; IEA:Ensembl.
DR GO; GO:0042026; P:protein refolding; IEA:Ensembl.
DR CDD; cd10233; HSPA1-2_6-8-like_NBD; 1.
DR Gene3D; 1.20.1270.10; -; 1.
DR Gene3D; 3.30.30.30; -; 1.
DR Gene3D; 3.30.420.40; -; 2.
DR InterPro; IPR043129; ATPase_NBD.
DR InterPro; IPR018181; Heat_shock_70_CS.
DR InterPro; IPR029048; HSP70_C_sf.
DR InterPro; IPR029047; HSP70_peptide-bd_sf.
DR InterPro; IPR013126; Hsp_70_fam.
DR PANTHER; PTHR19375:SF210; HEAT SHOCK 70 KDA PROTEIN 1-LIKE; 1.
DR PANTHER; PTHR19375; HEAT SHOCK PROTEIN 70KDA; 1.
DR Pfam; PF00012; HSP70; 1.
DR PRINTS; PR00301; HEATSHOCK70.
DR SUPFAM; SSF53067; Actin-like ATPase domain; 2.
DR SUPFAM; SSF100934; Heat shock protein 70kD (HSP70), C-terminal subdomain; 1.
DR SUPFAM; SSF100920; Heat shock protein 70kD (HSP70), peptide-binding domain; 1.
DR PROSITE; PS00297; HSP70_1; 1.
DR PROSITE; PS00329; HSP70_2; 1.
DR PROSITE; PS01036; HSP70_3; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|RuleBase:RU003322};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741,
KW ECO:0000256|RuleBase:RU003322};
KW Reference proteome {ECO:0000313|Proteomes:UP000291000}.
SQ SEQUENCE 642 AA; 70732 MW; 2D6B039B1239724F CRC64;
LYRDYMGTAI GIDLGTTYSC VGVFQHGKVE IIANDQGNRT TPSYVAFTDT ERLIGDAAKN
QVAMNPQNTV FDAKRLIGRK FNDPVVQSDM KLWPFQVINE GGKPKVMVSY KGEKKAFYPE
EISSMVLTKM KETAEAFLGY TVTNAVITVP AYFNDSQRQA TKDAGVIAGL NVLRIINEPT
AAAIAYGLDK AGQGERHVLI FDLGGGTFDV SVLTIDDGIF EVKATAGDTH LGGEDFDNRL
VSHFVEEFKR KHKKDISQNK RAVRRLRTAC ERAKRTLSSS TQANLEIDSL YEGIDFYTSI
TRARFEELCA DLFRGTLEPV EKALRDAKMD KAKIHDIVLV GGSTRIPKVQ RLLQDYFNGR
DLNKSINPDE AVAYGAAVQA AILMGDKSEK VQDLLLLDVA PLSLGLETAG GVMTVLIKRN
STIPTKQTQI FTTYSDNQPG VLIQVYEGER AMTRDNNLLG RFDLTGIPPA PRGVPQIEVT
FDIDANGILN VTAMDKSTGK ANKITITNDK GRLSKEEIER MVLDAEKYKA EDEVQREKIA
AKNALESYAF NMKSAVSDEG LQGKISESDK KKILSKCNEV LSWLEANQLA EKDEFDHKRK
ELEQVCNPII TKLYQGGCTG PSCGTGYTPG RAATGPTIEE VD
//
