ID A0A452FS46_CAPHI Unreviewed; 969 AA.
AC A0A452FS46;
DT 08-MAY-2019, integrated into UniProtKB/TrEMBL.
DT 08-MAY-2019, sequence version 1.
DT 27-MAR-2024, entry version 21.
DE SubName: Full=LDL receptor related protein 8 {ECO:0000313|Ensembl:ENSCHIP00000027043.1};
GN Name=LRP8 {ECO:0000313|Ensembl:ENSCHIP00000027043.1};
OS Capra hircus (Goat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC Caprinae; Capra.
OX NCBI_TaxID=9925 {ECO:0000313|Ensembl:ENSCHIP00000027043.1, ECO:0000313|Proteomes:UP000291000};
RN [1] {ECO:0000313|Ensembl:ENSCHIP00000027043.1, ECO:0000313|Proteomes:UP000291000}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Bickhart D.M., Koren S., Rosen B., Hastie A., Liachko I., Sullivan S.T.,
RA Burton J., Sayre B.L., Huson H.J., Lee J., Lam E., Kelley C.M.,
RA Hutchison J.L., Zhou Y., Sun J., Crisa A., Schwartz J.C., Hammond J.A.,
RA Schroeder S.G., Liu G.E., Dunham M., Shendure J., Sonstegard T.S.,
RA Phillippy A.M., Van Tassell C.P., Smith T.P.;
RT "Polished mammalian reference genomes with single-molecule sequencing and
RT chromosome conformation capture applied to the Capra hircus genome.";
RL Submitted (APR-2016) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSCHIP00000027043.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00076}.
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DR EMBL; LWLT01000004; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; A0A452FS46; -.
DR Ensembl; ENSCHIT00000034910.1; ENSCHIP00000027043.1; ENSCHIG00000023113.1.
DR GeneTree; ENSGT00940000154819; -.
DR Proteomes; UP000291000; Chromosome 3.
DR Bgee; ENSCHIG00000023113; Expressed in testis and 15 other cell types or tissues.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR GO; GO:0006897; P:endocytosis; IEA:UniProtKB-KW.
DR CDD; cd00054; EGF_CA; 1.
DR CDD; cd00112; LDLa; 6.
DR Gene3D; 2.10.25.10; Laminin; 3.
DR Gene3D; 4.10.400.10; Low-density Lipoprotein Receptor; 7.
DR Gene3D; 2.120.10.30; TolB, C-terminal domain; 1.
DR InterPro; IPR011042; 6-blade_b-propeller_TolB-like.
DR InterPro; IPR001881; EGF-like_Ca-bd_dom.
DR InterPro; IPR000742; EGF-like_dom.
DR InterPro; IPR000152; EGF-type_Asp/Asn_hydroxyl_site.
DR InterPro; IPR018097; EGF_Ca-bd_CS.
DR InterPro; IPR036055; LDL_receptor-like_sf.
DR InterPro; IPR023415; LDLR_class-A_CS.
DR InterPro; IPR000033; LDLR_classB_rpt.
DR InterPro; IPR002172; LDrepeatLR_classA_rpt.
DR PANTHER; PTHR24270; LOW-DENSITY LIPOPROTEIN RECEPTOR-RELATED; 1.
DR PANTHER; PTHR24270:SF3; LOW-DENSITY LIPOPROTEIN RECEPTOR-RELATED PROTEIN 8; 1.
DR Pfam; PF07645; EGF_CA; 1.
DR Pfam; PF14670; FXa_inhibition; 1.
DR Pfam; PF00057; Ldl_recept_a; 7.
DR Pfam; PF00058; Ldl_recept_b; 5.
DR PRINTS; PR00261; LDLRECEPTOR.
DR SMART; SM00181; EGF; 4.
DR SMART; SM00179; EGF_CA; 2.
DR SMART; SM00192; LDLa; 7.
DR SMART; SM00135; LY; 5.
DR SUPFAM; SSF57196; EGF/Laminin; 3.
DR SUPFAM; SSF57424; LDL receptor-like module; 7.
DR SUPFAM; SSF63825; YWTD domain; 1.
DR PROSITE; PS00010; ASX_HYDROXYL; 2.
DR PROSITE; PS01186; EGF_2; 2.
DR PROSITE; PS50026; EGF_3; 1.
DR PROSITE; PS01187; EGF_CA; 1.
DR PROSITE; PS01209; LDLRA_1; 3.
DR PROSITE; PS50068; LDLRA_2; 7.
DR PROSITE; PS51120; LDLRB; 4.
PE 4: Predicted;
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157, ECO:0000256|PROSITE-
KW ProRule:PRU00076};
KW EGF-like domain {ECO:0000256|ARBA:ARBA00022536, ECO:0000256|PROSITE-
KW ProRule:PRU00076}; Endocytosis {ECO:0000256|ARBA:ARBA00022583};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Receptor {ECO:0000256|ARBA:ARBA00023170};
KW Reference proteome {ECO:0000313|Proteomes:UP000291000};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}; Signal {ECO:0000256|SAM:SignalP};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..27
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 28..969
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5019295558"
FT TRANSMEM 819..842
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 370..409
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT REPEAT 456..502
FT /note="LDL-receptor class B"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00461"
FT REPEAT 503..545
FT /note="LDL-receptor class B"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00461"
FT REPEAT 546..589
FT /note="LDL-receptor class B"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00461"
FT REPEAT 590..634
FT /note="LDL-receptor class B"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00461"
FT REGION 739..810
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT DISULFID 42..54
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 49..67
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 61..76
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 81..93
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 88..106
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 143..158
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 162..174
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 169..187
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 181..196
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 261..279
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 273..288
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 293..305
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 300..318
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 312..327
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 374..384
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
SQ SEQUENCE 969 AA; 106315 MW; AC59EA349804AF21 CRC64;
MGRPERGALR PLALLLLLLQ LQHLAAAAAD PLRGGQGSVK ECEENQFRCR NERCIPSVWR
CDEDDDCSDN SDEDDCPKKT CADSDFTCND GHCIRERWKC DGEEDCPDGS DESEATCTKQ
VCPAEKLSCG PSSHKCVPAS WRCDGEKDCE SGADEAGCAT LCAPHEFQCS NRSCLAAVFV
CDGDDDCGDG SDERGCADPA CGPREFRCSG DSGACIPERW VCDRQFDCED RSDEAPELCG
RAGPRATPAP AACAAAAQFA CRSGECVHLG WRCDGDRDCK DKSDEADCPL GTCRGDEFQC
GDGTCVPAIK RCNQEQDCPD GSDETGCLQG LNECLHNNGG CSHICTDLKI GFECTCPAGY
QLLDQKTCGD IDECEDPDAC SQICVNYKGY FKCECHPGYE MDTLTKNCKA VAGRSPSLIF
TNRHEVRRID LVKRDYSRLI PMLKNVVALD VEVATNRIYW CDLSYRKIYS AYMDKASNPV
EQDVLIDEQL HSPEGLAVDW VHKHIYWTDS GNKTISVATV DGKRRCTLFS RNLSEPRAIA
VDPLRGFMYW SDWGFQAKIE KSGLNGVGRQ TLVSDGIEWP NGITLDLLNQ RLYWVDSKLH
QLSSIDFNGG NRKMLISSPD FLSHPFGIAV FEDKVFWTDL ENEAIFSANR LNGLEISILA
ENLNNPHDIV IFHELKQPRA ADACELSAQP NGGCEYLCLP APQISSHSPK YTCACPDTMW
LGPDMRRCYR APQSTSTTTL ASTTARTLAD TTRAPGTTIH SPAYQNHSTE TPSLSTVVPS
SVSVPRAPSI SPSTPSPATS NHSQHYGNEG GKMGSTVTAA VIGIIVPMVV IALLCMSGYL
IWRNWKRKNT KSMNFDNPVY RKTTEEEEED ELHIGRTAQI GHVYPAAISS FDHPLWAEPC
LGETRELEDP APALKELFVL PGEPRSQPHQ LPKNPLSELP VVKCKVGQCH SESEGLMSEG
MNQTGAANP
//
