ID A0A452FU39_CAPHI Unreviewed; 753 AA.
AC A0A452FU39;
DT 08-MAY-2019, integrated into UniProtKB/TrEMBL.
DT 08-MAY-2019, sequence version 1.
DT 24-JAN-2024, entry version 19.
DE RecName: Full=Cullin-5 {ECO:0000256|ARBA:ARBA00040451};
GN Name=CUL5 {ECO:0000313|Ensembl:ENSCHIP00000027898.1};
OS Capra hircus (Goat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC Caprinae; Capra.
OX NCBI_TaxID=9925 {ECO:0000313|Ensembl:ENSCHIP00000027898.1, ECO:0000313|Proteomes:UP000291000};
RN [1] {ECO:0000313|Ensembl:ENSCHIP00000027898.1, ECO:0000313|Proteomes:UP000291000}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Bickhart D.M., Koren S., Rosen B., Hastie A., Liachko I., Sullivan S.T.,
RA Burton J., Sayre B.L., Huson H.J., Lee J., Lam E., Kelley C.M.,
RA Hutchison J.L., Zhou Y., Sun J., Crisa A., Schwartz J.C., Hammond J.A.,
RA Schroeder S.G., Liu G.E., Dunham M., Shendure J., Sonstegard T.S.,
RA Phillippy A.M., Van Tassell C.P., Smith T.P.;
RT "Polished mammalian reference genomes with single-molecule sequencing and
RT chromosome conformation capture applied to the Capra hircus genome.";
RL Submitted (APR-2016) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSCHIP00000027898.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- PATHWAY: Protein modification; protein ubiquitination.
CC {ECO:0000256|ARBA:ARBA00004906}.
CC -!- SIMILARITY: Belongs to the cullin family.
CC {ECO:0000256|ARBA:ARBA00006019, ECO:0000256|PROSITE-ProRule:PRU00330,
CC ECO:0000256|RuleBase:RU003829}.
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DR EMBL; LWLT01000015; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; A0A452FU39; -.
DR Ensembl; ENSCHIT00000035767.1; ENSCHIP00000027898.1; ENSCHIG00000023581.1.
DR GeneTree; ENSGT00940000156648; -.
DR UniPathway; UPA00143; -.
DR Proteomes; UP000291000; Chromosome 15.
DR Bgee; ENSCHIG00000023581; Expressed in longissimus thoracis muscle and 16 other cell types or tissues.
DR GO; GO:0031461; C:cullin-RING ubiquitin ligase complex; IEA:InterPro.
DR GO; GO:0031625; F:ubiquitin protein ligase binding; IEA:InterPro.
DR GO; GO:0016567; P:protein ubiquitination; IEA:UniProtKB-UniPathway.
DR GO; GO:0006511; P:ubiquitin-dependent protein catabolic process; IEA:InterPro.
DR Gene3D; 1.20.1310.10; Cullin Repeats; 4.
DR Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 1.
DR InterPro; IPR045093; Cullin.
DR InterPro; IPR016157; Cullin_CS.
DR InterPro; IPR016158; Cullin_homology.
DR InterPro; IPR036317; Cullin_homology_sf.
DR InterPro; IPR001373; Cullin_N.
DR InterPro; IPR019559; Cullin_neddylation_domain.
DR InterPro; IPR016159; Cullin_repeat-like_dom_sf.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR InterPro; IPR036390; WH_DNA-bd_sf.
DR PANTHER; PTHR11932; CULLIN; 1.
DR PANTHER; PTHR11932:SF76; CULLIN-5; 1.
DR Pfam; PF00888; Cullin; 1.
DR Pfam; PF10557; Cullin_Nedd8; 1.
DR SMART; SM00182; CULLIN; 1.
DR SMART; SM00884; Cullin_Nedd8; 1.
DR SUPFAM; SSF75632; Cullin homology domain; 1.
DR SUPFAM; SSF74788; Cullin repeat-like; 1.
DR SUPFAM; SSF46785; Winged helix' DNA-binding domain; 1.
DR PROSITE; PS01256; CULLIN_1; 1.
DR PROSITE; PS50069; CULLIN_2; 1.
PE 3: Inferred from homology;
KW Isopeptide bond {ECO:0000256|ARBA:ARBA00022499};
KW Reference proteome {ECO:0000313|Proteomes:UP000291000};
KW Ubl conjugation {ECO:0000256|ARBA:ARBA00022843};
KW Ubl conjugation pathway {ECO:0000256|ARBA:ARBA00022786}.
FT DOMAIN 376..611
FT /note="Cullin family profile"
FT /evidence="ECO:0000259|PROSITE:PS50069"
SQ SEQUENCE 753 AA; 87883 MW; 031C9B1BD6CAAF0A CRC64;
NKGSLQFEDK WDFMRPIVLK LLRQESVTKQ QWFDLFSDVH AVCLWDDKGP AKIHQALKED
ILEFIKQAQA RVLSHQDDTA LLKAYIVEWR KFFTQCDILP KPFCQLEITL MGKQGSNKKS
NVEDSIVRKL MLDTWNESIF SNIKNRLQDS AMKLVHAERL GEAFDSQLVI GVRESYVNLC
SNPEDKLQIY RDNFEKAYLD STERFYRTQA PSYLQQNGVQ NYMKYADAKL KEEEKRALRY
LETRRECNSV EAVSNFVVLC PILSELHLMF SLMDKVPNGI EPMLKDLEEH IISAGLADMV
AAAETITTDS EKYVEQLLTL FNRFSKLVKE AFQDDPRFLT ARDKAYKAVV NDATIFKLEL
PLKQKGVGLK TQPESKCPEL LANYCDMLLR KTPLSKKLTS EEIEAKLKEV LLVLKYVQNK
DVFMRYHKAH LTRRLILDIS ADSEIEENMV EWLREVGMPA DYVNKLARMF QDIKVSEDLN
QAFKEMHKNN KLALPADSVN IKILNAGAWS RSSEKVFVSL PTELEDLIPE VEEFYKKNHS
GRKLHWHHLM SNGIITFKNE VGQYDLEVTT FQLAVLFAWN QRPREKISFE NLKLATELPD
AELRRTLWSL VAFPKLKRQV LLYEPQVNSP KDFTEGTLFS VNQEFSLIKN AKVQKRGKIN
LIGRLQLTTE RMREEENEGI VQLRILRTQE AIIQIMKMRK KISNAQLQTE LVEILKNMFL
PQKKMIKEQI EWLIEHKYIR RDESDINTFI YMA
//