ID A0A452FU44_CAPHI Unreviewed; 354 AA.
AC A0A452FU44;
DT 08-MAY-2019, integrated into UniProtKB/TrEMBL.
DT 08-MAY-2019, sequence version 1.
DT 27-MAR-2024, entry version 25.
DE RecName: Full=Hyaluronan and proteoglycan link protein 1 {ECO:0000256|ARBA:ARBA00040183};
DE AltName: Full=Cartilage-linking protein 1 {ECO:0000256|ARBA:ARBA00042100};
DE AltName: Full=Proteoglycan link protein {ECO:0000256|ARBA:ARBA00042980};
GN Name=HAPLN1 {ECO:0000313|Ensembl:ENSCHIP00000027903.1};
OS Capra hircus (Goat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC Caprinae; Capra.
OX NCBI_TaxID=9925 {ECO:0000313|Ensembl:ENSCHIP00000027903.1, ECO:0000313|Proteomes:UP000291000};
RN [1] {ECO:0000313|Ensembl:ENSCHIP00000027903.1, ECO:0000313|Proteomes:UP000291000}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Bickhart D.M., Koren S., Rosen B., Hastie A., Liachko I., Sullivan S.T.,
RA Burton J., Sayre B.L., Huson H.J., Lee J., Lam E., Kelley C.M.,
RA Hutchison J.L., Zhou Y., Sun J., Crisa A., Schwartz J.C., Hammond J.A.,
RA Schroeder S.G., Liu G.E., Dunham M., Shendure J., Sonstegard T.S.,
RA Phillippy A.M., Van Tassell C.P., Smith T.P.;
RT "Polished mammalian reference genomes with single-molecule sequencing and
RT chromosome conformation capture applied to the Capra hircus genome.";
RL Submitted (APR-2016) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSCHIP00000027903.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- FUNCTION: Stabilizes the aggregates of proteoglycan monomers with
CC hyaluronic acid in the extracellular cartilage matrix.
CC {ECO:0000256|ARBA:ARBA00037563}.
CC -!- SUBCELLULAR LOCATION: Secreted, extracellular space, extracellular
CC matrix {ECO:0000256|ARBA:ARBA00004498}.
CC -!- SIMILARITY: Belongs to the HAPLN family.
CC {ECO:0000256|ARBA:ARBA00038272}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00323}.
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DR EMBL; LWLT01000008; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_005683456.1; XM_005683399.3.
DR STRING; 9925.ENSCHIP00000027901; -.
DR Ensembl; ENSCHIT00000035770.1; ENSCHIP00000027901.1; ENSCHIG00000023635.1.
DR Ensembl; ENSCHIT00000035773.1; ENSCHIP00000027903.1; ENSCHIG00000023635.1.
DR GeneID; 102169475; -.
DR KEGG; chx:102169475; -.
DR CTD; 1404; -.
DR GeneTree; ENSGT00940000159267; -.
DR OMA; ERACHDQ; -.
DR OrthoDB; 5402504at2759; -.
DR Proteomes; UP000291000; Chromosome 7.
DR Bgee; ENSCHIG00000023635; Expressed in ovary and 13 other cell types or tissues.
DR GO; GO:0031012; C:extracellular matrix; IEA:Ensembl.
DR GO; GO:0045202; C:synapse; IEA:Ensembl.
DR GO; GO:0005540; F:hyaluronic acid binding; IEA:UniProtKB-KW.
DR GO; GO:0007155; P:cell adhesion; IEA:InterPro.
DR CDD; cd05877; Ig_LP_like; 1.
DR CDD; cd03518; Link_domain_HAPLN_module_1; 1.
DR CDD; cd03519; Link_domain_HAPLN_module_2; 1.
DR Gene3D; 2.60.40.10; Immunoglobulins; 1.
DR Gene3D; 3.10.100.10; Mannose-Binding Protein A, subunit A; 2.
DR InterPro; IPR016186; C-type_lectin-like/link_sf.
DR InterPro; IPR016187; CTDL_fold.
DR InterPro; IPR007110; Ig-like_dom.
DR InterPro; IPR036179; Ig-like_dom_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR003599; Ig_sub.
DR InterPro; IPR013106; Ig_V-set.
DR InterPro; IPR000538; Link_dom.
DR PANTHER; PTHR22804; AGGRECAN/VERSICAN PROTEOGLYCAN; 1.
DR PANTHER; PTHR22804:SF10; HYALURONAN AND PROTEOGLYCAN LINK PROTEIN 1; 1.
DR Pfam; PF07686; V-set; 1.
DR Pfam; PF00193; Xlink; 2.
DR PRINTS; PR01265; LINKMODULE.
DR SMART; SM00409; IG; 1.
DR SMART; SM00406; IGv; 1.
DR SMART; SM00445; LINK; 2.
DR SUPFAM; SSF56436; C-type lectin-like; 2.
DR SUPFAM; SSF48726; Immunoglobulin; 1.
DR PROSITE; PS50835; IG_LIKE; 1.
DR PROSITE; PS01241; LINK_1; 2.
DR PROSITE; PS50963; LINK_2; 2.
PE 3: Inferred from homology;
KW Disulfide bond {ECO:0000256|PROSITE-ProRule:PRU00323};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Hyaluronic acid {ECO:0000256|ARBA:ARBA00023290};
KW Immunoglobulin domain {ECO:0000256|ARBA:ARBA00023319};
KW Reference proteome {ECO:0000313|Proteomes:UP000291000};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}; Signal {ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..15
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 16..354
FT /note="Hyaluronan and proteoglycan link protein 1"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5040596426"
FT DOMAIN 38..152
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 159..254
FT /note="Link"
FT /evidence="ECO:0000259|PROSITE:PS50963"
FT DOMAIN 259..351
FT /note="Link"
FT /evidence="ECO:0000259|PROSITE:PS50963"
FT DISULFID 205..226
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00323"
FT DISULFID 304..325
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00323"
SQ SEQUENCE 354 AA; 40253 MW; 0F41984546B68D7D CRC64;
MKSLLLLVLI SICWADHHSN NYTVDHDRVI HIQAENGPRL LVEAEQAKVF SRRGGNVTLP
CKFYRDPTAF GSGTHKIRIK WTKLTSDYLK EVDVFVSMGY HKKTYGGYHG RVFLKGGSDN
DASLVITDLT LEDYGRYKCE VIEGLEDDTA VVALDLQGVV FPYFPRLGRY NLNFHEAQQA
CLDQDAVIAS FDQLYDAWRS GLDWCNAGWL SDGSVQYPIT KPREPCGGQN TVPGVRNYGF
WDKDKSRYDV FCFTSNFNGR FYYLIHPTKL TYDEAVQACL NDGAQIAKVG QIFAAWKLLG
YDRCDAGWLA DGSVRYPISR PRRRCSPSEA AVRFVGFPDK KHKLYGVYCF RAYN
//
