ID A0A452FVL8_CAPHI Unreviewed; 470 AA.
AC A0A452FVL8;
DT 08-MAY-2019, integrated into UniProtKB/TrEMBL.
DT 08-MAY-2019, sequence version 1.
DT 24-JAN-2024, entry version 19.
DE RecName: Full=IF rod domain-containing protein {ECO:0000259|PROSITE:PS51842};
GN Name=LOC102185150 {ECO:0000313|Ensembl:ENSCHIP00000028449.1};
OS Capra hircus (Goat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC Caprinae; Capra.
OX NCBI_TaxID=9925 {ECO:0000313|Ensembl:ENSCHIP00000028449.1, ECO:0000313|Proteomes:UP000291000};
RN [1] {ECO:0000313|Ensembl:ENSCHIP00000028449.1, ECO:0000313|Proteomes:UP000291000}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Bickhart D.M., Koren S., Rosen B., Hastie A., Liachko I., Sullivan S.T.,
RA Burton J., Sayre B.L., Huson H.J., Lee J., Lam E., Kelley C.M.,
RA Hutchison J.L., Zhou Y., Sun J., Crisa A., Schwartz J.C., Hammond J.A.,
RA Schroeder S.G., Liu G.E., Dunham M., Shendure J., Sonstegard T.S.,
RA Phillippy A.M., Van Tassell C.P., Smith T.P.;
RT "Polished mammalian reference genomes with single-molecule sequencing and
RT chromosome conformation capture applied to the Capra hircus genome.";
RL Submitted (APR-2016) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSCHIP00000028449.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the intermediate filament family.
CC {ECO:0000256|RuleBase:RU000685}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; LWLT01000005; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; A0A452FVL8; -.
DR Ensembl; ENSCHIT00000036319.1; ENSCHIP00000028449.1; ENSCHIG00000023937.1.
DR GeneTree; ENSGT00940000154026; -.
DR Proteomes; UP000291000; Chromosome 5.
DR Bgee; ENSCHIG00000023937; Expressed in cerebellum and 6 other cell types or tissues.
DR GO; GO:0045095; C:keratin filament; IEA:InterPro.
DR Gene3D; 1.20.5.170; -; 1.
DR Gene3D; 1.20.5.500; Single helix bin; 1.
DR Gene3D; 1.20.5.1160; Vasodilator-stimulated phosphoprotein; 1.
DR InterPro; IPR018039; IF_conserved.
DR InterPro; IPR039008; IF_rod_dom.
DR InterPro; IPR032444; Keratin_2_head.
DR InterPro; IPR003054; Keratin_II.
DR PANTHER; PTHR45616; GATA-TYPE DOMAIN-CONTAINING PROTEIN; 1.
DR PANTHER; PTHR45616:SF51; IF ROD DOMAIN-CONTAINING PROTEIN; 1.
DR Pfam; PF00038; Filament; 1.
DR Pfam; PF16208; Keratin_2_head; 1.
DR PRINTS; PR01276; TYPE2KERATIN.
DR SMART; SM01391; Filament; 1.
DR SUPFAM; SSF64593; Intermediate filament protein, coiled coil region; 2.
DR PROSITE; PS00226; IF_ROD_1; 1.
DR PROSITE; PS51842; IF_ROD_2; 1.
PE 3: Inferred from homology;
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054, ECO:0000256|SAM:Coils};
KW Intermediate filament {ECO:0000256|ARBA:ARBA00022754,
KW ECO:0000256|RuleBase:RU000685}; Keratin {ECO:0000256|ARBA:ARBA00022744};
KW Reference proteome {ECO:0000313|Proteomes:UP000291000}.
FT DOMAIN 111..420
FT /note="IF rod"
FT /evidence="ECO:0000259|PROSITE:PS51842"
FT COILED 115..212
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 304..398
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 470 AA; 52752 MW; A7F9248100603BB9 CRC64;
TCRNSSSSVT TQRYCPGRTF SCVSAGGSRP SRCCVTAAPY RGVSCYRGLT GGFSSRSVCG
GSRAGSSSHS FGYRSGGSSP PCITSVSVNQ SLLKPLNLEI DHNAQRVKNQ EKEQIKSLNS
KFAAFIDKVR FLEQQNKLLE TKWQLYQNQR CCESNLGPLF NGYIETLRRE AERVEADTGR
LASELNHVQE VLEGYKKKYE EEVALKTTAE NEFVKIKQEV NHVYVRKGDL EANAQSLVEE
VGFLKTLYEE VIIQAHISDT SVIVKMDNSR YLNMDSIIAE IKAHYDEIAS RSRAEAESWY
RSKYEEIKAT VNRHGETLRR TKEEISELNR LIQRLTAEIE NAKSQNSKLE AAVTQAEQQG
EAALNDARGK LAGLEKALQN AKQDMASLLK QYQEVMSSKL GLDIEIATYR RLLEGEEQRW
VQSAQLGPQL QRPGPFFFSL YYFPIPSSAH ILEPFLAPSL LRGEAENSLS
//
