ID A0A452FVS5_CAPHI Unreviewed; 513 AA.
AC A0A452FVS5;
DT 08-MAY-2019, integrated into UniProtKB/TrEMBL.
DT 08-MAY-2019, sequence version 1.
DT 24-JAN-2024, entry version 18.
DE RecName: Full=DNA polymerase epsilon subunit {ECO:0000256|PIRNR:PIRNR000799};
DE AltName: Full=DNA polymerase II subunit 2 {ECO:0000256|PIRNR:PIRNR000799};
GN Name=POLE2 {ECO:0000313|Ensembl:ENSCHIP00000028315.1};
OS Capra hircus (Goat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC Caprinae; Capra.
OX NCBI_TaxID=9925 {ECO:0000313|Ensembl:ENSCHIP00000028315.1, ECO:0000313|Proteomes:UP000291000};
RN [1] {ECO:0000313|Ensembl:ENSCHIP00000028315.1, ECO:0000313|Proteomes:UP000291000}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Bickhart D.M., Koren S., Rosen B., Hastie A., Liachko I., Sullivan S.T.,
RA Burton J., Sayre B.L., Huson H.J., Lee J., Lam E., Kelley C.M.,
RA Hutchison J.L., Zhou Y., Sun J., Crisa A., Schwartz J.C., Hammond J.A.,
RA Schroeder S.G., Liu G.E., Dunham M., Shendure J., Sonstegard T.S.,
RA Phillippy A.M., Van Tassell C.P., Smith T.P.;
RT "Polished mammalian reference genomes with single-molecule sequencing and
RT chromosome conformation capture applied to the Capra hircus genome.";
RL Submitted (APR-2016) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSCHIP00000028315.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- FUNCTION: Participates in DNA repair and in chromosomal DNA
CC replication. {ECO:0000256|PIRNR:PIRNR000799}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123,
CC ECO:0000256|PIRNR:PIRNR000799}.
CC -!- SIMILARITY: Belongs to the DNA polymerase epsilon subunit B family.
CC {ECO:0000256|ARBA:ARBA00009560, ECO:0000256|PIRNR:PIRNR000799}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; LWLT01000010; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; A0A452FVS5; -.
DR Ensembl; ENSCHIT00000036185.1; ENSCHIP00000028315.1; ENSCHIG00000023859.1.
DR GeneTree; ENSGT00390000012435; -.
DR Proteomes; UP000291000; Chromosome 10.
DR Bgee; ENSCHIG00000023859; Expressed in thymus and 17 other cell types or tissues.
DR GO; GO:0008622; C:epsilon DNA polymerase complex; IEA:UniProtKB-UniRule.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-UniRule.
DR GO; GO:0006261; P:DNA-templated DNA replication; IEA:InterPro.
DR Gene3D; 1.10.8.60; -; 1.
DR Gene3D; 3.60.21.60; -; 1.
DR InterPro; IPR007185; DNA_pol_a/d/e_bsu.
DR InterPro; IPR024639; DNA_pol_e_bsu_N.
DR InterPro; IPR016266; POLE2.
DR PANTHER; PTHR12708:SF0; DNA POLYMERASE EPSILON SUBUNIT 2; 1.
DR PANTHER; PTHR12708; DNA POLYMERASE EPSILON SUBUNIT B; 1.
DR Pfam; PF04042; DNA_pol_E_B; 1.
DR Pfam; PF12213; Dpoe2NT; 1.
DR PIRSF; PIRSF000799; DNA_pol_eps_2; 1.
PE 3: Inferred from homology;
KW DNA replication {ECO:0000256|ARBA:ARBA00022705,
KW ECO:0000256|PIRNR:PIRNR000799};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125, ECO:0000256|PIRNR:PIRNR000799};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242, ECO:0000256|PIRNR:PIRNR000799};
KW Reference proteome {ECO:0000313|Proteomes:UP000291000}.
FT DOMAIN 3..74
FT /note="DNA polymerase epsilon subunit B N-terminal"
FT /evidence="ECO:0000259|Pfam:PF12213"
FT DOMAIN 273..474
FT /note="DNA polymerase alpha/delta/epsilon subunit B"
FT /evidence="ECO:0000259|Pfam:PF04042"
SQ SEQUENCE 513 AA; 58270 MW; 65AF824EA622F0CC CRC64;
MAPERLRSRA LSAFKLRGLM LRGEAVKYLT EALQSINEIE LEDALEKIID AVEKQPLSSN
MIERSVVEAA VQECSQSVDE TIDHIFNIIG AFDIPRFVYN SERKKFLPLL MTNHPAPNLF
GTARDKAELF RERYTILHQR THRHELFTPP VIGSHPDESG SKFQLKTIET LLGSTSKIGD
VIVLGMITQL KEHSSFIFSL QTEIGHWNVF FIESWFEDQV FHVNAFGFPP TEPSSTTRAY
YGNINFFGGP SNTSVKTSAK LKQLEDENKD AMFVFISDVW LDQVEVLEKL HIMFSGYSPA
PPTCFILCGN FSSAPYGKNQ VQALKDSLKT LADIICEYPN IHQSSRFVFV PGPEDPGFGS
ILPRPPFAES ITNEFRQRVP FSVFTTNPCR IQYCTQEIIV FREDLVNKMC RNCVRFPSSN
LDIPNHFVKT VLSQGHLTPL PLYVCPVYWA YDYALRVYPV PDLLVIADKY DPFTLTNTEC
LCINPGSFPR SGFSFKVFYP SNKIVEDSKL QGF
//
