ID A0A452FW15_CAPHI Unreviewed; 4373 AA.
AC A0A452FW15;
DT 08-MAY-2019, integrated into UniProtKB/TrEMBL.
DT 08-MAY-2019, sequence version 1.
DT 27-MAR-2024, entry version 22.
DE SubName: Full=Vacuolar protein sorting 13 homolog D {ECO:0000313|Ensembl:ENSCHIP00000028561.1};
GN Name=VPS13D {ECO:0000313|Ensembl:ENSCHIP00000028561.1};
OS Capra hircus (Goat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC Caprinae; Capra.
OX NCBI_TaxID=9925 {ECO:0000313|Ensembl:ENSCHIP00000028561.1, ECO:0000313|Proteomes:UP000291000};
RN [1] {ECO:0000313|Ensembl:ENSCHIP00000028561.1, ECO:0000313|Proteomes:UP000291000}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Bickhart D.M., Koren S., Rosen B., Hastie A., Liachko I., Sullivan S.T.,
RA Burton J., Sayre B.L., Huson H.J., Lee J., Lam E., Kelley C.M.,
RA Hutchison J.L., Zhou Y., Sun J., Crisa A., Schwartz J.C., Hammond J.A.,
RA Schroeder S.G., Liu G.E., Dunham M., Shendure J., Sonstegard T.S.,
RA Phillippy A.M., Van Tassell C.P., Smith T.P.;
RT "Polished mammalian reference genomes with single-molecule sequencing and
RT chromosome conformation capture applied to the Capra hircus genome.";
RL Submitted (APR-2016) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSCHIP00000028561.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the VPS13 family.
CC {ECO:0000256|ARBA:ARBA00006545}.
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DR EMBL; LWLT01000016; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR Ensembl; ENSCHIT00000036431.1; ENSCHIP00000028561.1; ENSCHIG00000023196.1.
DR GeneTree; ENSGT00950000183083; -.
DR OMA; LFGTCPT; -.
DR Proteomes; UP000291000; Chromosome 16.
DR Bgee; ENSCHIG00000023196; Expressed in adult mammalian kidney and 17 other cell types or tissues.
DR GO; GO:0006869; P:lipid transport; IEA:UniProtKB-KW.
DR CDD; cd14306; UBA_VP13D; 1.
DR Gene3D; 1.10.8.10; DNA helicase RuvA subunit, C-terminal domain; 1.
DR InterPro; IPR015940; UBA.
DR InterPro; IPR009060; UBA-like_sf.
DR InterPro; IPR041969; VP13D_UBA.
DR InterPro; IPR026847; VPS13.
DR InterPro; IPR026854; VPS13-like_N.
DR InterPro; IPR031645; VPS13_DH-like.
DR InterPro; IPR031646; VPS13_extend_chorein.
DR InterPro; IPR031642; VPS13_mid_RBG.
DR InterPro; IPR009543; VPS13_VAB.
DR PANTHER; PTHR16166:SF141; INTERMEMBRANE LIPID TRANSFER PROTEIN VPS13D; 1.
DR PANTHER; PTHR16166; VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN VPS13; 1.
DR Pfam; PF12624; Chorein_N; 1.
DR Pfam; PF00627; UBA; 1.
DR Pfam; PF16909; VPS13_DH-like; 1.
DR Pfam; PF16908; VPS13_ext_chorein; 1.
DR Pfam; PF16910; VPS13_mid_rpt; 2.
DR Pfam; PF06650; VPS13_VAB; 1.
DR SMART; SM00165; UBA; 1.
DR SUPFAM; SSF46934; UBA-like; 1.
DR PROSITE; PS50030; UBA; 1.
PE 3: Inferred from homology;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Lipid transport {ECO:0000256|ARBA:ARBA00023055};
KW Reference proteome {ECO:0000313|Proteomes:UP000291000};
KW Transport {ECO:0000256|ARBA:ARBA00022448}.
FT DOMAIN 2633..2676
FT /note="UBA"
FT /evidence="ECO:0000259|PROSITE:PS50030"
FT REGION 403..428
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 745..796
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1741..1770
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2070..2146
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 100..127
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 745..766
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2070..2087
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2118..2143
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 4373 AA; 489296 MW; 6E4A4E6B8B470463 CRC64;
MLEGLVAWVL NTYLGKYVNN LNTDQLSVAL LKGAVELENL PLKKDALKEL ELPFEVKAGL
IGKVTLQIPF YRPHVDPWVI SISSLHLIGA PEKIQDFNDE KEKLLERERK KALLQALEEK
WKNERQQKGE SYWYSVTASV VTRIVENIEL KIQDVHLRFE DGVTNPSHPF AFGICIKNVS
MQNAMNEPVQ KLMRKKQLDV AEFSIYWDVD CTLLGDLPQV ELQEAMDRSM ESRDHHYILE
PVCASALLKR NCSKEPLRSR HTPRIECDIH LETIPLKLSQ LQYRQIMEFL KELERKERQV
KFRKWKPKVA VSENCREWWY FALNANLHEI REQRKRCTWG FLLGRARDAV SYTDKYFTTL
RGGLLSADDK EEMYRIEEEQ SFEELKILRE LVHERFHKQE ELAESLREPQ LDPLGDSPGD
PGPRGGSGML QYLQSWFPGW GGWYGQQSPE GKPVEGLMAE PQEQWTPEEI LGSEEFFDPT
ADASCMNTYT KRDHVFAKLN LQLQRGTVTL LHQEQGAPQM NQSAFMQLEF SGVKLLAESL
PRRNSSLLLV RLGGLFLQDL ATEGTMFPLL VFPNPQKEVG RVSQSFGLQT ASADRSHHYP
AADPDDPVFE MLYERNPVHS HFERRLNVST RPLNIIYNPQ AIKKVADFFY KGKVHTSGFG
YQSELELRVA EAARRQYNRL KMQTKAEIRQ TLDRLLVGDF IEESKRWTVR LDISAPQVIF
PDDFKFKNPV LVVVDLGRML LTNTQDDSKR KNGDGSALEE NQFSDDEYKT PLATPPNTPP
PETSSSNGEK TPPFSGVKFS EEQLQAHLMS TKMYERYSLS FLDLQIMVGR VKDNWKHVQD
IDVGPTHVVE KFNVHLQLER RLIYTSDPKY PGAVLSGNLP DLKIHINEDK ISALKNCFAL
LTTPETKTFD SQMKEKIFPQ GGQRGSLQDS VMNLTQSIVM LEQHTREVLV ESQLLLAEFK
VNCMQLGVES NGRYISVLKV FGTNAHFVKR PYDAEVSLTV HGLLLVDTMQ TYGADFDLLM
ASHKNLSFDI PTGSLRDSRA QSPVSGSNVA HLTSAATRNN QSATSISLDR VLTKEQESLI
KLEYQFVSSE CPSMNLDSTL QVISLQVNNL DIILNPETIV ELIGFLQKSF PKEKDELSPQ
PLMTDFERSF REQGTYQSTY EQNTEVAVEI HRLNLLLLRT VGMANGEKYG RKIATASIGG
TKVNVSMGNT FDMNGSLGCL QLMDLTQENV KNQYVVSIGN SVGYENIISD IGFYESVFVR
MEDAALTDAL SFTFVEKSKQ ECFLNLKMAS LHYNHSAKFL KELTLSMDEL EENFRSMLKS
AATKVTTVLA TKTAEYSEMV SLFETPRKAR DSFFLEENEP YGFGLGASHS DTVKLILNIN
IESPVVSIPR KPGSPELLVG HLGQIFIQNF VAGDDESRSD RLQVEIKDIK LYSLNCTQLT
GREGPGLEMS RAFCPLSGSA NANSQEEAHF TRHDFFESLH RGQAFHILNN TTIQFKLEKI
PIERESELTF SLSPDDLGAS SIMKIEGKFV NPVQVVLAKH VYEQVLQTLD NLVYSEDLNK
FPVSAASSPC PNSPLPPLSI CGEPSAERKE NGLFSHSSLS NSSQKSLSVK EVKSFTQIQA
NFCISELQVQ LSGDLTLGAQ GLVSLKFQDF EVEFSKDHPQ TLSIQIALHS LLMEDLLEKN
PDSKYKNLMV SRGAPKPSSL AQKEYLSQSC PSVSNVEYPD MPRSLPSHME EAPNVFQLYQ
RPTSASRKKQ KEVQDKDYPL TPPPSPTVDE PKILAGKSKF DDSLVHINVF LVDKKHPEFS
SSYNRVNRSI DVDFNCLDVL ITLQTWVVIL DFFGIGSTAD NHAMKVPPED VLQSVKSESS
ALAESELQDP VNTKLDLKVH SLSLVLNKTT SELAKANVSK LVAHLEMIEG DLALQGSIGS
LSLSDLTSHG EFYRERFTTS GEEALIFQTF KYGRPDPLLR REHDVRVSLQ MASVQYVHTQ
RFQAEVVAFI QHFTQLQDVL GRQRAAIEGQ TVRDQAQRCS RVLLDIEAGA PVLLIPESSR
SNNLIVANLG KLKVKNKFLF AGFPGTFTLQ DKESVPSSSP TDTPKHSVRK MTSMEDLKGT
HSEGLIMMPP AGMSPGSLKS ESVPSTSTRP QGQPATPSVG RASSSPEDHV CLLDCIVVDL
QDMDIFAAER HPREYSRVSE NSSGDLIFPS YFVRQTGGSL LTEPCRLKLQ VERNLDKEIS
HTVPDISIHG NLSSVHCSLD LCKYKLIRGL LENNLGEPIE EFMRPYDLQD PRIHTVLSGE
VYTCMCFLID MVNVSLELKD PKGKEGAGSL ARFDFKKCKL LYESFSNQTK SVNLVSHSMM
AFDTRSAGQK TSPGVTNVFT CIFQPSKSSS TTQGSIQIEL HFRSTKDSSC FTVVLNNLRV
FLIFDWLLLV HDFLHTPSDI KKPAKVTPFR HRNSSSESAV IPKTVKSGVV TKRSSLPVST
ERHLEVKVNV TGTEFVVVED ISCFDTNAII LKGTTVLTYK PRFVDRPFSG SLFGIEVFSC
RLGNEQDTAL SIVDPVQIHV ELVGNSSYQN SSGLMDAFNS EDFPPILEIQ LQALDIRLSY
NDVQLFLAIA KSIPEQANAA VPDAAALEAS SVHSYLPGAS RGGEEVREGT RHTLDPVLEL
QLARLQELGF SMDDCRKALL VCQGQLKKAA SWLFKNAEPR TSLSLASNSQ QSQGVAPAQL
ISGVEMKAES VCICFIDDCM DCDVPLAELT FSRLNFLQHV RTSPEGYAHF TLSGDYYNRA
LSGWEPFIEP WPCSVSWQQQ AASRLHPPRL KLEAKAKQRL DVNITSVLID QYISTKESWM
ADYCKQDKEV DPTPSEDWMG SSVDPPCFGQ SLPLVYLRTR STASLTNLEH QIYARAEMKA
PKRRQPFVPF ALRNHTGCTL WFATLTTTPT RAALSHSGSP GVVPEGNGTL LDDAHNVSEW
REVLTGEEIP FEFEARGKLR HRHTHDLRIH QLQVRVNGWE QVSPVSVDKV GTFFRYAAPD
KNSSSSTFSS LPPVRVVFAV TMEGSARKVI TVRSALIVKN RLETPMELRL DSPSAPDKPV
VLPAIMPGDS FAVPLHLTSW RLQARPKGLG VFFCKAPIHW TNVVKTAEVS SSKRECHSMD
TEKSRFFRFC VAIKKENYPD YMPSNIFSDS AKQIFRQPGH TIYLLPTVVI CNLLPCELDF
YVKGMPINGT LKPGKEVALH TADTSQNIEL GVSLENFPLC KELLIPPGTQ NYMVRMRLYD
TNRRQLNLTI RIVCRAEGSL KIFISAPYWL INKTGLPLIF RQDNAKTDAA GQFEEHELAR
SLSPLLFCYA DKEQPNLCTM RIGRGIHPEG MPGWCQGFSL DGGSGVRALR VIQQGNRPGL
IYNIGIDVKK GRGRYIDTCM VIFAPRYLLD NKSSHKLAFA QREFARGQGT ANPEGYISTL
PGSSVVFHWP RNDYDQLLCV RLMDVPNCIW SGGFEVNKNN SFHINMRDTL GKCFFLRVEI
TLRGATYRIS FSDTDQLPPP FRIDNFSKVP VVFTQHGVAE PRLRTEVKPM TSLDYAWDEP
TLPPFITLTV KGAGSSEISC NMNDFQDNQQ LYYENFIYIA ATYTFSGLQE GTGRPVASNK
AITCAELVLD VSPKTQRVIL KKKEPGKRSQ LWRMTGTGML AHEGSSVPHN PSEPSAARSA
EGSAILDIAG LAAVTDNRYE PLMLRKPDRR RSTTQTWSFR EGKLTCGLHG LVVQAKGGLS
GLFDGAEVVL GPDTSMELLG PVPPEQQFIN QKMRPGSGML SIRVVPDGPT RALQITDFSQ
RKSDRSSYEV DELPVTEREL QKLKNPDTEQ ELEVLVKLEG GIGLSLINKV PEELVFASLT
GINVHYTQLA TSHMLELSIQ DVQVDNQLIG TTQPFMLYVT PLSNENEVIE TGPAVQVNAV
KFPSKSALTN IYKHLMVTAQ RFTVQIEEKL LLKLLSFFGY DQAESEVEKY DENLHEKTAE
QGGTPIRYYF ENLKISIPQI KLSVFTANKL PLDLKALKST LGFPLIRFED AVINLDPFTR
VHPYETKDFI INDILKHFQE ELLSQAARIL GSVDFLGNPM GLLNDVSEGV TGLIKYGNVG
GLIRNVTHGV SNSAAKFAGT LSDGLGKTMD NRHQSEREYI RYHAATSGEH LVAGIHGLAH
GIIGGLTSVI TSTVEGVKTE GGVSGFISGL GKGLVGTVTK PVAGALDFAS ETAQAVRDTA
TLSGPRTQAQ RVRKPRCCTG PQGLLPRYSE SQAEGQEQLF KLTDNIQDEF FIAVENIDSY
CVLISSKAVY FLRSGDYVDR EAIFLEVKYD DLYHCLVSKD HGKVYVQVTK KAVNTSSGVS
IPGPSHQKPM VHVKSEVLAI KLSQEINYAK SLYYEQQLML RLSENQEQLE LDS
//
