ID A0A452FWX3_CAPHI Unreviewed; 313 AA.
AC A0A452FWX3;
DT 08-MAY-2019, integrated into UniProtKB/TrEMBL.
DT 08-MAY-2019, sequence version 1.
DT 27-MAR-2024, entry version 18.
DE SubName: Full=Growth arrest specific 2 {ECO:0000313|Ensembl:ENSCHIP00000028807.1};
GN Name=GAS2 {ECO:0000313|Ensembl:ENSCHIP00000028807.1};
OS Capra hircus (Goat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC Caprinae; Capra.
OX NCBI_TaxID=9925 {ECO:0000313|Ensembl:ENSCHIP00000028807.1, ECO:0000313|Proteomes:UP000291000};
RN [1] {ECO:0000313|Ensembl:ENSCHIP00000028807.1, ECO:0000313|Proteomes:UP000291000}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Bickhart D.M., Koren S., Rosen B., Hastie A., Liachko I., Sullivan S.T.,
RA Burton J., Sayre B.L., Huson H.J., Lee J., Lam E., Kelley C.M.,
RA Hutchison J.L., Zhou Y., Sun J., Crisa A., Schwartz J.C., Hammond J.A.,
RA Schroeder S.G., Liu G.E., Dunham M., Shendure J., Sonstegard T.S.,
RA Phillippy A.M., Van Tassell C.P., Smith T.P.;
RT "Polished mammalian reference genomes with single-molecule sequencing and
RT chromosome conformation capture applied to the Capra hircus genome.";
RL Submitted (APR-2016) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSCHIP00000028807.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the GAS2 family.
CC {ECO:0000256|ARBA:ARBA00038441}.
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DR EMBL; LWLT01000026; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_017899097.1; XM_018043608.1.
DR Ensembl; ENSCHIT00000036671.1; ENSCHIP00000028801.1; ENSCHIG00000024172.1.
DR Ensembl; ENSCHIT00000036677.1; ENSCHIP00000028807.1; ENSCHIG00000024172.1.
DR Ensembl; ENSCHIT00010042893.1; ENSCHIP00010030431.1; ENSCHIG00010022661.1.
DR Ensembl; ENSCHIT00010042950.1; ENSCHIP00010030476.1; ENSCHIG00010022661.1.
DR GeneID; 102184501; -.
DR KEGG; chx:102184501; -.
DR CTD; 2620; -.
DR GeneTree; ENSGT00940000155755; -.
DR OMA; GLHGCDY; -.
DR OrthoDB; 1361287at2759; -.
DR Proteomes; UP000291000; Chromosome 29.
DR Proteomes; UP000694566; Chromosome 29.
DR Bgee; ENSCHIG00000024172; Expressed in liver and 5 other cell types or tissues.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR GO; GO:0005856; C:cytoskeleton; IEA:UniProtKB-KW.
DR GO; GO:0008017; F:microtubule binding; IEA:InterPro.
DR CDD; cd21267; CH_GAS2; 1.
DR Gene3D; 1.10.418.10; Calponin-like domain; 1.
DR Gene3D; 3.30.920.20; Gas2-like domain; 1.
DR InterPro; IPR001715; CH_dom.
DR InterPro; IPR036872; CH_dom_sf.
DR InterPro; IPR003108; GAR_dom.
DR InterPro; IPR036534; GAR_dom_sf.
DR PANTHER; PTHR46756:SF9; GROWTH ARREST-SPECIFIC PROTEIN 2; 1.
DR PANTHER; PTHR46756; TRANSGELIN; 1.
DR Pfam; PF00307; CH; 1.
DR Pfam; PF02187; GAS2; 1.
DR SMART; SM00033; CH; 1.
DR SMART; SM00243; GAS2; 1.
DR SUPFAM; SSF47576; Calponin-homology domain, CH-domain; 1.
DR SUPFAM; SSF143575; GAS2 domain-like; 1.
DR PROSITE; PS50021; CH; 1.
DR PROSITE; PS51460; GAR; 1.
PE 3: Inferred from homology;
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Cytoskeleton {ECO:0000256|ARBA:ARBA00023212};
KW Reference proteome {ECO:0000313|Proteomes:UP000291000}.
FT DOMAIN 34..156
FT /note="Calponin-homology (CH)"
FT /evidence="ECO:0000259|PROSITE:PS50021"
FT DOMAIN 197..270
FT /note="GAR"
FT /evidence="ECO:0000259|PROSITE:PS51460"
FT REGION 175..199
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 178..199
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 313 AA; 34856 MW; DB2FF865FF1A573B CRC64;
MCTALSPKVR SGPGLSDMHQ YSQWLASRHE ANLLPMKEDL ALWLTNLLGK EITAETFMEK
LDNGALLCQL AETVQEKFKE SMDTAKPTKN LPLKKIPCKA SAPSGSFFAR DNTANFLSWC
RDLGVDETCL FESEGLVLHK QPREVCLCLL ELGRIAARYG VEPPGLIKLE KEIEQEETLS
APSPSPSPSS KSSGKKSTGN LLDDAVKRIS EDPPCKCPSK FCVERLSQGR YRVGEKILFI
RMLHNKHVMV RVGGGWETFA GYLLKHDPCR MLQISRVDGK TSPVQSKSPT LKDMNPDNYL
VVSANYKAKK EIK
//
