ID A0A452G091_CAPHI Unreviewed; 686 AA.
AC A0A452G091;
DT 08-MAY-2019, integrated into UniProtKB/TrEMBL.
DT 08-MAY-2019, sequence version 1.
DT 24-JAN-2024, entry version 23.
DE SubName: Full=Scm polycomb group protein homolog 1 {ECO:0000313|Ensembl:ENSCHIP00000030003.1};
GN Name=SCMH1 {ECO:0000313|Ensembl:ENSCHIP00000030003.1};
OS Capra hircus (Goat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC Caprinae; Capra.
OX NCBI_TaxID=9925 {ECO:0000313|Ensembl:ENSCHIP00000030003.1, ECO:0000313|Proteomes:UP000291000};
RN [1] {ECO:0000313|Ensembl:ENSCHIP00000030003.1, ECO:0000313|Proteomes:UP000291000}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Bickhart D.M., Koren S., Rosen B., Hastie A., Liachko I., Sullivan S.T.,
RA Burton J., Sayre B.L., Huson H.J., Lee J., Lam E., Kelley C.M.,
RA Hutchison J.L., Zhou Y., Sun J., Crisa A., Schwartz J.C., Hammond J.A.,
RA Schroeder S.G., Liu G.E., Dunham M., Shendure J., Sonstegard T.S.,
RA Phillippy A.M., Van Tassell C.P., Smith T.P.;
RT "Polished mammalian reference genomes with single-molecule sequencing and
RT chromosome conformation capture applied to the Capra hircus genome.";
RL Submitted (APR-2016) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSCHIP00000030003.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the SCM family. {ECO:0000256|ARBA:ARBA00008469}.
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DR EMBL; LWLT01000004; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; A0A452G091; -.
DR STRING; 9925.ENSCHIP00000030003; -.
DR Ensembl; ENSCHIT00000037873.1; ENSCHIP00000030003.1; ENSCHIG00000024918.1.
DR GeneTree; ENSGT00940000157999; -.
DR OMA; NKEFCSM; -.
DR Proteomes; UP000291000; Chromosome 3.
DR Bgee; ENSCHIG00000024918; Expressed in uterus and 18 other cell types or tissues.
DR GO; GO:0010369; C:chromocenter; IEA:Ensembl.
DR GO; GO:0001673; C:male germ cell nucleus; IEA:Ensembl.
DR GO; GO:0009952; P:anterior/posterior pattern specification; IEA:Ensembl.
DR GO; GO:0006338; P:chromatin remodeling; IEA:Ensembl.
DR GO; GO:0006355; P:regulation of DNA-templated transcription; IEA:InterPro.
DR GO; GO:0007283; P:spermatogenesis; IEA:Ensembl.
DR CDD; cd20105; MBT_SCMH1_rpt1; 1.
DR CDD; cd20108; MBT_SCMH1_rpt2; 1.
DR CDD; cd09578; SAM_Scm; 1.
DR Gene3D; 2.30.30.140; -; 2.
DR Gene3D; 3.90.1150.190; SLED domain; 1.
DR Gene3D; 1.10.150.50; Transcription Factor, Ets-1; 1.
DR InterPro; IPR004092; Mbt.
DR InterPro; IPR047279; MBT_SCMH1_rpt1.
DR InterPro; IPR047280; MBT_SCMH1_rpt2.
DR InterPro; IPR001660; SAM.
DR InterPro; IPR013761; SAM/pointed_sf.
DR InterPro; IPR047531; SAM_Scm-like.
DR InterPro; IPR033763; SCML2_RBR.
DR InterPro; IPR021987; SLED.
DR InterPro; IPR038348; SLED_sf.
DR PANTHER; PTHR12247; POLYCOMB GROUP PROTEIN; 1.
DR PANTHER; PTHR12247:SF68; POLYCOMB PROTEIN SCMH1; 1.
DR Pfam; PF02820; MBT; 2.
DR Pfam; PF17208; RBR; 1.
DR Pfam; PF00536; SAM_1; 1.
DR Pfam; PF12140; SLED; 1.
DR SMART; SM00561; MBT; 2.
DR SMART; SM00454; SAM; 1.
DR SUPFAM; SSF47769; SAM/Pointed domain; 1.
DR SUPFAM; SSF63748; Tudor/PWWP/MBT; 2.
DR PROSITE; PS51079; MBT; 2.
DR PROSITE; PS50105; SAM_DOMAIN; 1.
PE 3: Inferred from homology;
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000291000};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Repressor {ECO:0000256|ARBA:ARBA00022491}.
FT REPEAT 28..126
FT /note="MBT"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00459"
FT REPEAT 134..235
FT /note="MBT"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00459"
FT DOMAIN 594..659
FT /note="SAM"
FT /evidence="ECO:0000259|PROSITE:PS50105"
FT REGION 233..345
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 556..589
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 250..268
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 686 AA; 75841 MW; 4123FC0EB34D6A25 CRC64;
MLVCYSVLAC ESLWDLTCSI MGSPLGHFTW DKYLKETCSV PAPIHCFKQS YTPPSNEFKI
SMKLEAQDPR NTTSTCIATV VGLTGARLRL RLDGSDNKND FWRLVDSAEI QPIGNCEKNG
GMLQPPLGFR LNASSWPMFL LKTLNGAEMA PIRIFHKEPP SPSHNFFKMG MKLEAVDRKN
PHFICPATIG EVRGSEVLVT FDGWRGAFDY WCRFDSRDIF PVGWCSLTGD NLQPPGTKVV
IPKNPYPASD VNTEKPSIHS STKTVLEHQP GQRGRKPGKK RGRTPKPLIP HPISTPSKSA
EPLKFPKKRG PKPGSKRKPR TLLNPPPTSP TTSTPEPDTS TVPQDAATIP SSAMQAPTVC
IYLNKNGSTG PHLDKKKVQQ LPDHFGPARA SVVLQQAVQA CIDCAYHQKT VFSFLKQGHG
GAVISAVFDR EQHTLNLPAV NSITYVLRFL EKLCHNLRSD NLFGNQPFTQ THLSLTTTEY
SHSHDRYLPG ETFALGNSLA RSLEPHSDSM DSALNPTNLV STSQNLRNPG YRPLLPSCGL
PLSTASAVRR LCSRGNGHTG PLGQAVESAG ELQPSPRSDR RDASRLSGRD PSLWTVEDVM
QFVREADPQF GPHADLFRKH EIDGKALLLL RSDTMMKYMG LKLGPALKLC YHIDRLKQGP
LRRAVAPSQR TLPRHFLLGM DRPAKP
//
