ID A0A452G0E5_CAPHI Unreviewed; 795 AA.
AC A0A452G0E5;
DT 08-MAY-2019, integrated into UniProtKB/TrEMBL.
DT 08-MAY-2019, sequence version 1.
DT 24-JAN-2024, entry version 20.
DE SubName: Full=Rho GTPase activating protein 12 {ECO:0000313|Ensembl:ENSCHIP00000029779.1};
GN Name=ARHGAP12 {ECO:0000313|Ensembl:ENSCHIP00000029779.1};
OS Capra hircus (Goat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC Caprinae; Capra.
OX NCBI_TaxID=9925 {ECO:0000313|Ensembl:ENSCHIP00000029779.1, ECO:0000313|Proteomes:UP000291000};
RN [1] {ECO:0000313|Ensembl:ENSCHIP00000029779.1, ECO:0000313|Proteomes:UP000291000}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Bickhart D.M., Koren S., Rosen B., Hastie A., Liachko I., Sullivan S.T.,
RA Burton J., Sayre B.L., Huson H.J., Lee J., Lam E., Kelley C.M.,
RA Hutchison J.L., Zhou Y., Sun J., Crisa A., Schwartz J.C., Hammond J.A.,
RA Schroeder S.G., Liu G.E., Dunham M., Shendure J., Sonstegard T.S.,
RA Phillippy A.M., Van Tassell C.P., Smith T.P.;
RT "Polished mammalian reference genomes with single-molecule sequencing and
RT chromosome conformation capture applied to the Capra hircus genome.";
RL Submitted (APR-2016) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSCHIP00000029779.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
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DR EMBL; LWLT01000014; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_017912665.1; XM_018057176.1.
DR AlphaFoldDB; A0A452G0E5; -.
DR Ensembl; ENSCHIT00000037649.1; ENSCHIP00000029779.1; ENSCHIG00000024718.1.
DR GeneID; 102184916; -.
DR CTD; 94134; -.
DR GeneTree; ENSGT00950000182860; -.
DR OrthoDB; 5395569at2759; -.
DR Proteomes; UP000291000; Chromosome 13.
DR Bgee; ENSCHIG00000024718; Expressed in prefrontal cortex and 16 other cell types or tissues.
DR GO; GO:0005096; F:GTPase activator activity; IEA:UniProtKB-KW.
DR GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR CDD; cd13233; PH_ARHGAP9-like; 1.
DR CDD; cd04403; RhoGAP_ARHGAP27_15_12_9; 1.
DR CDD; cd12070; SH3_ARHGAP12; 1.
DR CDD; cd00201; WW; 1.
DR Gene3D; 2.20.70.10; -; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR Gene3D; 1.10.555.10; Rho GTPase activation protein; 1.
DR Gene3D; 2.30.30.40; SH3 Domains; 1.
DR InterPro; IPR035491; ARHGAP12_SH3.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR001849; PH_domain.
DR InterPro; IPR008936; Rho_GTPase_activation_prot.
DR InterPro; IPR000198; RhoGAP_dom.
DR InterPro; IPR036028; SH3-like_dom_sf.
DR InterPro; IPR001452; SH3_domain.
DR InterPro; IPR001202; WW_dom.
DR InterPro; IPR036020; WW_dom_sf.
DR PANTHER; PTHR23176:SF107; RHO GTPASE-ACTIVATING PROTEIN 12; 1.
DR PANTHER; PTHR23176; RHO/RAC/CDC GTPASE-ACTIVATING PROTEIN; 1.
DR Pfam; PF00169; PH; 1.
DR Pfam; PF00620; RhoGAP; 1.
DR Pfam; PF16618; SH3-WW_linker; 1.
DR Pfam; PF00397; WW; 1.
DR SMART; SM00233; PH; 1.
DR SMART; SM00324; RhoGAP; 1.
DR SMART; SM00456; WW; 2.
DR SUPFAM; SSF48350; GTPase activation domain, GAP; 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR SUPFAM; SSF50044; SH3-domain; 1.
DR SUPFAM; SSF51045; WW domain; 2.
DR PROSITE; PS50003; PH_DOMAIN; 1.
DR PROSITE; PS50238; RHOGAP; 1.
DR PROSITE; PS50002; SH3; 1.
DR PROSITE; PS50020; WW_DOMAIN_2; 2.
PE 4: Predicted;
KW GTPase activation {ECO:0000256|ARBA:ARBA00022468};
KW Reference proteome {ECO:0000313|Proteomes:UP000291000};
KW SH3 domain {ECO:0000256|ARBA:ARBA00022443, ECO:0000256|PROSITE-
KW ProRule:PRU00192}.
FT DOMAIN 12..74
FT /note="SH3"
FT /evidence="ECO:0000259|PROSITE:PS50002"
FT DOMAIN 266..299
FT /note="WW"
FT /evidence="ECO:0000259|PROSITE:PS50020"
FT DOMAIN 312..345
FT /note="WW"
FT /evidence="ECO:0000259|PROSITE:PS50020"
FT DOMAIN 423..524
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT DOMAIN 605..793
FT /note="Rho-GAP"
FT /evidence="ECO:0000259|PROSITE:PS50238"
FT REGION 153..181
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 197..242
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 293..323
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 382..413
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 528..579
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 153..171
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 200..242
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 299..313
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 539..577
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 795 AA; 90054 MW; 48149DEFB6B7102A CRC64;
MKMADRGGKI LPGPVYIEVE YDYEYEAKDR KVVIKQGERY LLVKKTNADW WQVKPDESSK
AFYVPAQYVK EVGRRALMPP VKPATGLPNH SVKTVQSLHL QRSSENVNRL PELSSFGKTS
SSSVQGTGLV RDANQNFGPS YIPGQTVNLS LDLTHNNGKL NSDSHSPKVP GQNRTRLFGH
FPGPEFLEVE KAGFPQEQSC DSAGEGSERI QQDSESGDEL SSSSTEQIRA TTPPNQGRPD
SPVYANLQEL KISQSALPPV PGSPAIQING EWETHKDSSG RCYYYNRGTQ ERTWKPPRWT
RDTNTSKGDS QSPGDQEWLK HVDDQGRQYY YSADGSRSEW ELPKYNASSQ QQREIIKSRS
LDRRLQEPIV LSKWRHSTIV LDANDKESPS ASKPCYPEHE SSPSSPKHQD TGQEKYGLLN
VTKITENGKK VRKNWLSSWA VLQGSSLLFT KTQGSSTSWF GSNQSKPEFT VDLKGATIEM
ASKDKSSKKN VFELKTRQGT ELLIQSDNDT VINDWFKVLS STISNQTVEP DEAIEEEIPD
SPGIEKHDKE KDQKEPKKLR STKVSSIDSS EQKKTKKNLK KFLTRRPTLQ AVREKGYIKD
QVFGANLSNL CQRENSTVPK FVKLCIEHVE QYGLDVDGIY RVSGNLAVIQ KLRFAVNHDE
KLDLKDSKWE DIHVITGALK MFFRELPEPL FTFNHFNDFV NAIKQEPRQR VSAVKDLIKQ
LPKPNQDTMQ ILFRHLKRVI ENGEKNRMTY QSIAIVFGPT LLKPEKETGN IAVHTVYQNQ
IVELILLEIN SIFGR
//
