ID A0A452G149_CAPHI Unreviewed; 1064 AA.
AC A0A452G149;
DT 08-MAY-2019, integrated into UniProtKB/TrEMBL.
DT 08-MAY-2019, sequence version 1.
DT 24-JAN-2024, entry version 25.
DE SubName: Full=Pleckstrin and Sec7 domain containing 4 {ECO:0000313|Ensembl:ENSCHIP00000030142.1};
GN Name=PSD4 {ECO:0000313|Ensembl:ENSCHIP00000030142.1};
OS Capra hircus (Goat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC Caprinae; Capra.
OX NCBI_TaxID=9925 {ECO:0000313|Ensembl:ENSCHIP00000030142.1, ECO:0000313|Proteomes:UP000291000};
RN [1] {ECO:0000313|Ensembl:ENSCHIP00000030142.1, ECO:0000313|Proteomes:UP000291000}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Bickhart D.M., Koren S., Rosen B., Hastie A., Liachko I., Sullivan S.T.,
RA Burton J., Sayre B.L., Huson H.J., Lee J., Lam E., Kelley C.M.,
RA Hutchison J.L., Zhou Y., Sun J., Crisa A., Schwartz J.C., Hammond J.A.,
RA Schroeder S.G., Liu G.E., Dunham M., Shendure J., Sonstegard T.S.,
RA Phillippy A.M., Van Tassell C.P., Smith T.P.;
RT "Polished mammalian reference genomes with single-molecule sequencing and
RT chromosome conformation capture applied to the Capra hircus genome.";
RL Submitted (APR-2016) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSCHIP00000030142.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cell projection, ruffle membrane
CC {ECO:0000256|ARBA:ARBA00004632}.
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DR EMBL; LWLT01000009; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_017910828.1; XM_018055339.1.
DR RefSeq; XP_017910829.1; XM_018055340.1.
DR RefSeq; XP_017910830.1; XM_018055341.1.
DR AlphaFoldDB; A0A452G149; -.
DR STRING; 9925.ENSCHIP00000030142; -.
DR Ensembl; ENSCHIT00000038012.1; ENSCHIP00000030142.1; ENSCHIG00000025022.1.
DR GeneID; 102183970; -.
DR KEGG; chx:102183970; -.
DR CTD; 23550; -.
DR GeneTree; ENSGT00940000161976; -.
DR OMA; AKEMTSW; -.
DR OrthoDB; 204547at2759; -.
DR Proteomes; UP000291000; Chromosome 11.
DR Bgee; ENSCHIG00000025022; Expressed in thymus and 13 other cell types or tissues.
DR GO; GO:0032587; C:ruffle membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:InterPro.
DR GO; GO:0005543; F:phospholipid binding; IEA:InterPro.
DR GO; GO:0032012; P:regulation of ARF protein signal transduction; IEA:InterPro.
DR CDD; cd13295; PH_EFA6; 1.
DR CDD; cd00171; Sec7; 1.
DR Gene3D; 1.10.1000.11; Arf Nucleotide-binding Site Opener,domain 2; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR041681; PH_9.
DR InterPro; IPR001605; PH_dom-spectrin-type.
DR InterPro; IPR001849; PH_domain.
DR InterPro; IPR023394; Sec7_C_sf.
DR InterPro; IPR000904; Sec7_dom.
DR InterPro; IPR035999; Sec7_dom_sf.
DR PANTHER; PTHR10663; GUANYL-NUCLEOTIDE EXCHANGE FACTOR; 1.
DR PANTHER; PTHR10663:SF338; PH AND SEC7 DOMAIN-CONTAINING PROTEIN 4; 1.
DR Pfam; PF15410; PH_9; 1.
DR Pfam; PF01369; Sec7; 1.
DR PRINTS; PR00683; SPECTRINPH.
DR SMART; SM00233; PH; 1.
DR SMART; SM00222; Sec7; 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR SUPFAM; SSF48425; Sec7 domain; 1.
DR PROSITE; PS50003; PH_DOMAIN; 1.
DR PROSITE; PS50190; SEC7; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000291000}.
FT DOMAIN 573..745
FT /note="SEC7"
FT /evidence="ECO:0000259|PROSITE:PS50190"
FT DOMAIN 785..900
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT REGION 98..152
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 194..245
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 291..337
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 352..378
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 398..588
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 752..775
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1012..1064
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 114..152
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 398..420
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 519..534
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1037..1053
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1064 AA; 116338 MW; 8970D3838CB0C6B5 CRC64;
MQKGQGTCGV LVAPLASASS NPHYGLVKVD APEGSNAAYA HWMMGDDGLC GHPRPVEILD
ICLGDNLQPH LEAHLGETCG HPEPLEPHRE QTWVSVPPDA VRPDVCPQGS SPEPMHVGSG
SSQERAGQKS TSPGSPRDNQ PPGSPGQSQS TSTQVVFWAG ILQAQMCVLD LEEELEKTEG
LRAELRCCIP ASPADLPTFP SSPVGPRNSG LLPSPPLDAD EASGEDSSGP EGETQNPAWP
REGTLDLSPE WSAEEESIFF DNPLFLESPC SDTSASETHF SWGFSDSYVD VRTGPQSPQT
LEPPPLGGRV PWELGDEPDL GESTAESSGH TTPPFPVPTY RPHSFSWVVV DTPEGAPAAP
SSQEETESSR RDSLDPALPA ASCVDKTLSW ETEHVEYNSS PATHPVQPWV GPSTQGWPTK
VIPSWPPGPL SSQDRGDRDT ECVQESGPCT VAPGHPLGSP ASSPEPSSPE SGVRGPDSLP
SPVSSREGSL RLQGHLPGSV LPKWTLDAPS PSFLETDGAE PDSLEKEEAG EAPTQGKEVK
LSPARTAEAG ASQPDACLTS AKSLPGSPMP QVQPPEEGQR PPAGDRLANG VRTDKVAWNL
ASRLYHLEGF RKSEVAAYLR KNNDFSRAVA EAYLSFFQFG GQSLDRALRG FLQALVLSGE
TQERERILYQ FSKRFHHCNP GLFSSVDCVH TLTCAIMLLN TDLHGQNIGK SMSCQEFITN
LNGLRDGGNF PKELLKALYW SIRSEKLEWA VDEEDTARPE KARPSPPAGK MSNPFLQLAQ
DPTVPTYKQG FLARKMHQDA DGKKTPWGKR GWKMLHTLLR GMVLYFLKGE DPGLDGESLV
GQMVDEPVGV HHSLATPATH YTKKPHVFQL RTADWRLYLF QAPTAQEMTS WIARINLAAA
THSAPPFPAA VGSQRKFVRP ILPVGPTQGS LEEQHRSHEN CLDAASDDLL DLQRNLPERR
GRSRELEDYR VRKEYLEYEK TRYETYLQLL VARLHCPSED LDLWEEQLGR EAGDLQEPKP
SLKKSHSSPS LHQDEAPTTA KVKRNISERR TYRKIIPKRN RNQL
//
