ID A0A452G1S2_CAPHI Unreviewed; 912 AA.
AC A0A452G1S2;
DT 08-MAY-2019, integrated into UniProtKB/TrEMBL.
DT 08-MAY-2019, sequence version 1.
DT 27-MAR-2024, entry version 23.
DE RecName: Full=Anoctamin {ECO:0000256|RuleBase:RU280814};
GN Name=ANO1 {ECO:0000313|Ensembl:ENSCHIP00000030373.1};
OS Capra hircus (Goat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC Caprinae; Capra.
OX NCBI_TaxID=9925 {ECO:0000313|Ensembl:ENSCHIP00000030373.1, ECO:0000313|Proteomes:UP000291000};
RN [1] {ECO:0000313|Ensembl:ENSCHIP00000030373.1, ECO:0000313|Proteomes:UP000291000}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Bickhart D.M., Koren S., Rosen B., Hastie A., Liachko I., Sullivan S.T.,
RA Burton J., Sayre B.L., Huson H.J., Lee J., Lam E., Kelley C.M.,
RA Hutchison J.L., Zhou Y., Sun J., Crisa A., Schwartz J.C., Hammond J.A.,
RA Schroeder S.G., Liu G.E., Dunham M., Shendure J., Sonstegard T.S.,
RA Phillippy A.M., Van Tassell C.P., Smith T.P.;
RT "Polished mammalian reference genomes with single-molecule sequencing and
RT chromosome conformation capture applied to the Capra hircus genome.";
RL Submitted (APR-2016) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSCHIP00000030373.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004651};
CC Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141, ECO:0000256|RuleBase:RU280814}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141,
CC ECO:0000256|RuleBase:RU280814}.
CC -!- SIMILARITY: Belongs to the anoctamin family.
CC {ECO:0000256|ARBA:ARBA00009671, ECO:0000256|RuleBase:RU280814}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|RuleBase:RU280814}.
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DR EMBL; LWLT01000026; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; A0A452G1S2; -.
DR Ensembl; ENSCHIT00000038245.1; ENSCHIP00000030373.1; ENSCHIG00000025110.1.
DR GeneTree; ENSGT00940000157182; -.
DR OMA; WKQRVRT; -.
DR Proteomes; UP000291000; Chromosome 29.
DR Bgee; ENSCHIG00000025110; Expressed in fallopian tube and 16 other cell types or tissues.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0046983; F:protein dimerization activity; IEA:InterPro.
DR InterPro; IPR032394; Anoct_dimer.
DR InterPro; IPR007632; Anoctamin.
DR InterPro; IPR049452; Anoctamin_TM.
DR PANTHER; PTHR12308; ANOCTAMIN; 1.
DR PANTHER; PTHR12308:SF13; ANOCTAMIN-1; 1.
DR Pfam; PF16178; Anoct_dimer; 2.
DR Pfam; PF04547; Anoctamin; 1.
PE 3: Inferred from homology;
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU280814};
KW Reference proteome {ECO:0000313|Proteomes:UP000291000};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW ECO:0000256|RuleBase:RU280814};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|RuleBase:RU280814}.
FT TRANSMEM 292..319
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU280814"
FT TRANSMEM 369..388
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU280814"
FT TRANSMEM 447..473
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU280814"
FT TRANSMEM 493..517
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU280814"
FT TRANSMEM 537..558
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU280814"
FT TRANSMEM 663..686
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU280814"
FT DOMAIN 54..231
FT /note="Anoctamin dimerisation"
FT /evidence="ECO:0000259|Pfam:PF16178"
FT DOMAIN 232..278
FT /note="Anoctamin dimerisation"
FT /evidence="ECO:0000259|Pfam:PF16178"
FT DOMAIN 281..857
FT /note="Anoctamin transmembrane"
FT /evidence="ECO:0000259|Pfam:PF04547"
FT REGION 76..120
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 876..912
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 876..890
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 912 AA; 105100 MW; 35859376D6D70B21 CRC64;
MRVNEKYSTL PAEDRSVHII NICAIEDIGY LPSEGTLLNS LSVDPDAECK YGLYFRDGKR
KVDYVLVYHH KRASGGRTLA RRAQQGDAGP AARSARHDQP LPGKAGPLGP GESEPPLDYH
EDDKRFRREE YEGNLVEAGL ELERDEDTKI HGVGFVKIHA PWNVLCREAE FLKLKMPTKK
LYHISETRGL LKKINSVLQK ITDPIQPKVA EHRPQTTKRL SYPFSREKQH LLLANGVYSA
AYPLHDGDYE GDNVEFNDRK LLYEEWACYG VFYKYQPIDL VRQYFGEKIG LYFAWLGVYT
QMLIPASVVG IIVFLYGWAT VDDNIPSMEM CDQRHNITMC PLCDRTCSYW KMSSACATAR
ASHLFDNPAT VFFSIFMALW AATFMEHWKR KQMRLNYRWD LTGFEEEEDH PRAEYEARVL
EKSLRKESKN KETDKVKLTW RDRFPAYFTN LVSIIFMIAV TFAIVLGVII YRISTAAALA
MNSSPSVRSN IRVTVTATAV IINLVVIILL DEVYGCIARW LTKIEVPKTE KSFEERLIFK
AFLLKFVNSY TPIFYVAFFK GRFVGRPGDY VYIFRSFRME ECAPGGCLME LCIQLSIIML
GKQLIQNNLF EIGIPKMKKF IRYLRLKHQS PSDHDEHAKK KQRYEVDYTL EPFAGLTPEY
MEMIIQFGFV TLFVASFPLA PLFALLNNII EIRLDAKKFV TELRRPVAVR AKDIGIWYNI
LRGVGKLAVI INAFVISFTS DFIPRLVYLY MYSENGTMHG FVNHTLSSFN VSDFQNGTAP
NDPLGLGYEV QICRYKDYRE PPWSEHKYDI SKDFWAVLAA RLAFVIVFQN LVMFMSDFVD
WVIPDIPKDI SQQIHKEKVL MVELFMREEQ GKQQLLDTWM EKDRKKAEPC NNHSPAPAAP
PPSQLVSDSE TP
//