ID A0A452G3T6_CAPHI Unreviewed; 576 AA.
AC A0A452G3T6;
DT 08-MAY-2019, integrated into UniProtKB/TrEMBL.
DT 08-MAY-2019, sequence version 1.
DT 24-JAN-2024, entry version 18.
DE RecName: Full=asparaginase {ECO:0000256|ARBA:ARBA00012920};
DE EC=3.5.1.1 {ECO:0000256|ARBA:ARBA00012920};
GN Name=ASPG {ECO:0000313|Ensembl:ENSCHIP00000031171.1};
OS Capra hircus (Goat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC Caprinae; Capra.
OX NCBI_TaxID=9925 {ECO:0000313|Ensembl:ENSCHIP00000031171.1, ECO:0000313|Proteomes:UP000291000};
RN [1] {ECO:0000313|Ensembl:ENSCHIP00000031171.1, ECO:0000313|Proteomes:UP000291000}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Bickhart D.M., Koren S., Rosen B., Hastie A., Liachko I., Sullivan S.T.,
RA Burton J., Sayre B.L., Huson H.J., Lee J., Lam E., Kelley C.M.,
RA Hutchison J.L., Zhou Y., Sun J., Crisa A., Schwartz J.C., Hammond J.A.,
RA Schroeder S.G., Liu G.E., Dunham M., Shendure J., Sonstegard T.S.,
RA Phillippy A.M., Van Tassell C.P., Smith T.P.;
RT "Polished mammalian reference genomes with single-molecule sequencing and
RT chromosome conformation capture applied to the Capra hircus genome.";
RL Submitted (APR-2016) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSCHIP00000031171.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
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DR EMBL; LWLT01000019; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; A0A452G3T6; -.
DR Ensembl; ENSCHIT00000039043.1; ENSCHIP00000031171.1; ENSCHIG00000025636.1.
DR GeneTree; ENSGT00390000001610; -.
DR OMA; HSTFRAF; -.
DR Proteomes; UP000291000; Chromosome 21.
DR Bgee; ENSCHIG00000025636; Expressed in liver and 8 other cell types or tissues.
DR GO; GO:0004067; F:asparaginase activity; IEA:UniProtKB-UniRule.
DR GO; GO:0009066; P:aspartate family amino acid metabolic process; IEA:UniProt.
DR CDD; cd08963; L-asparaginase_I; 1.
DR Gene3D; 3.40.50.40; -; 1.
DR Gene3D; 1.25.40.20; Ankyrin repeat-containing domain; 1.
DR Gene3D; 3.40.50.1170; L-asparaginase, N-terminal domain; 1.
DR InterPro; IPR002110; Ankyrin_rpt.
DR InterPro; IPR036770; Ankyrin_rpt-contain_sf.
DR InterPro; IPR036152; Asp/glu_Ase-like_sf.
DR InterPro; IPR006034; Asparaginase/glutaminase-like.
DR InterPro; IPR027475; Asparaginase/glutaminase_AS2.
DR InterPro; IPR040919; Asparaginase_C.
DR InterPro; IPR027473; L-asparaginase_C.
DR InterPro; IPR041725; L-asparaginase_I.
DR InterPro; IPR027474; L-asparaginase_N.
DR InterPro; IPR037152; L-asparaginase_N_sf.
DR PANTHER; PTHR11707:SF28; 60 KDA LYSOPHOSPHOLIPASE; 1.
DR PANTHER; PTHR11707; L-ASPARAGINASE; 1.
DR Pfam; PF12796; Ank_2; 1.
DR Pfam; PF00710; Asparaginase; 1.
DR Pfam; PF17763; Asparaginase_C; 1.
DR PIRSF; PIRSF001220; L-ASNase_gatD; 2.
DR PIRSF; PIRSF500176; L_ASNase; 1.
DR PRINTS; PR00139; ASNGLNASE.
DR SFLD; SFLDS00057; Glutaminase/Asparaginase; 1.
DR SMART; SM00248; ANK; 3.
DR SMART; SM00870; Asparaginase; 1.
DR SUPFAM; SSF48403; Ankyrin repeat; 1.
DR SUPFAM; SSF53774; Glutaminase/Asparaginase; 1.
DR PROSITE; PS50297; ANK_REP_REGION; 1.
DR PROSITE; PS50088; ANK_REPEAT; 1.
DR PROSITE; PS00917; ASN_GLN_ASE_2; 1.
DR PROSITE; PS51732; ASN_GLN_ASE_3; 1.
PE 4: Predicted;
KW ANK repeat {ECO:0000256|PROSITE-ProRule:PRU00023};
KW Reference proteome {ECO:0000313|Proteomes:UP000291000}.
FT DOMAIN 11..218
FT /note="L-asparaginase N-terminal"
FT /evidence="ECO:0000259|Pfam:PF00710"
FT DOMAIN 237..340
FT /note="Asparaginase/glutaminase C-terminal"
FT /evidence="ECO:0000259|Pfam:PF17763"
FT REPEAT 431..463
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT ACT_SITE 116
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU10100"
SQ SEQUENCE 576 AA; 61268 MW; 44FC9267DEE2AD15 CRC64;
MARAAGPERR LLAVYTGGTI GMRSERGVLV PGRGLAAVLR MLPMFHDEEH ARACGLPEDT
LVLPPASPDQ RVFYTVLECQ PLFDSSDMTI TEWVQIAQII ESHYARYDGF VVIHGTDTMA
FAASVLSFVL ENLQKTVILT GAQVPIHALW NDGRENLLGA LLLAGQYVIP EVCLFFQNQL
FRGNRVTKVD ARRFAAFCSP NLPPLAAVGA DVTINRELVC RVRGQGRLVV HSSMEQNVGL
LRLYPGIPAS LVRAFLQPPM KGVVMETFGS GNGPTKPDLL QELRAAAERG LVIINCTHCL
QGAVTSDYGA GVALSGAGTV PGFDMTSEAA LAKLSYVLGL PGLSLDGRKE LLARDLRGEM
TPPAADEPRP SLQGSVLGRG IAQLLSLRQE ADEMWDALVP SLACAAAYTG DLEALQVLVE
LGSDQSLEDF SGQTPLHAAA RAGQAGAVTM LLQRGLDVNA RDKGGLSPLL LAVGGRHRGV
IGLLRAAGAC LSAQELQDSG TELCRLASRA DCEGLRAWGQ AGADLRQPGY DGHSALHVVS
APEGSALDRA GPKLLVWVTR TSAPPAPRFR TLPPPQ
//
