ID A0A452G4U0_CAPHI Unreviewed; 5948 AA.
AC A0A452G4U0;
DT 08-MAY-2019, integrated into UniProtKB/TrEMBL.
DT 08-MAY-2019, sequence version 1.
DT 24-JAN-2024, entry version 20.
DE SubName: Full=Adhesion G protein-coupled receptor V1 {ECO:0000313|Ensembl:ENSCHIP00000031567.1};
GN Name=ADGRV1 {ECO:0000313|Ensembl:ENSCHIP00000031567.1};
OS Capra hircus (Goat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC Caprinae; Capra.
OX NCBI_TaxID=9925 {ECO:0000313|Ensembl:ENSCHIP00000031567.1, ECO:0000313|Proteomes:UP000291000};
RN [1] {ECO:0000313|Ensembl:ENSCHIP00000031567.1, ECO:0000313|Proteomes:UP000291000}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Bickhart D.M., Koren S., Rosen B., Hastie A., Liachko I., Sullivan S.T.,
RA Burton J., Sayre B.L., Huson H.J., Lee J., Lam E., Kelley C.M.,
RA Hutchison J.L., Zhou Y., Sun J., Crisa A., Schwartz J.C., Hammond J.A.,
RA Schroeder S.G., Liu G.E., Dunham M., Shendure J., Sonstegard T.S.,
RA Phillippy A.M., Van Tassell C.P., Smith T.P.;
RT "Polished mammalian reference genomes with single-molecule sequencing and
RT chromosome conformation capture applied to the Capra hircus genome.";
RL Submitted (APR-2016) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSCHIP00000031567.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; LWLT01000008; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR Ensembl; ENSCHIT00000039441.1; ENSCHIP00000031567.1; ENSCHIG00000025783.1.
DR GeneTree; ENSGT00940000154880; -.
DR Proteomes; UP000291000; Chromosome 7.
DR Bgee; ENSCHIG00000025783; Expressed in testis and 7 other cell types or tissues.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0004930; F:G protein-coupled receptor activity; IEA:InterPro.
DR GO; GO:0007166; P:cell surface receptor signaling pathway; IEA:InterPro.
DR Gene3D; 2.60.120.200; -; 1.
DR Gene3D; 2.60.220.50; -; 1.
DR Gene3D; 2.60.40.2030; -; 34.
DR Gene3D; 1.20.1070.10; Rhodopsin 7-helix transmembrane proteins; 1.
DR InterPro; IPR026919; ADGRV1.
DR InterPro; IPR038081; CalX-like_sf.
DR InterPro; IPR003644; Calx_beta.
DR InterPro; IPR013320; ConA-like_dom_sf.
DR InterPro; IPR009039; EAR.
DR InterPro; IPR005492; EPTP.
DR InterPro; IPR046338; GAIN_dom_sf.
DR InterPro; IPR017981; GPCR_2-like_7TM.
DR InterPro; IPR000832; GPCR_2_secretin-like.
DR InterPro; IPR000203; GPS.
DR InterPro; IPR006558; LamG-like.
DR PANTHER; PTHR46682; ADHESION G-PROTEIN COUPLED RECEPTOR V1; 1.
DR PANTHER; PTHR46682:SF1; ADHESION G-PROTEIN COUPLED RECEPTOR V1; 1.
DR Pfam; PF00002; 7tm_2; 1.
DR Pfam; PF03160; Calx-beta; 29.
DR Pfam; PF03736; EPTP; 1.
DR Pfam; PF13385; Laminin_G_3; 1.
DR SMART; SM00237; Calx_beta; 18.
DR SMART; SM00560; LamGL; 1.
DR SUPFAM; SSF141072; CalX-like; 36.
DR SUPFAM; SSF49899; Concanavalin A-like lectins/glucanases; 1.
DR PROSITE; PS50912; EAR; 6.
DR PROSITE; PS50261; G_PROTEIN_RECEP_F2_4; 1.
DR PROSITE; PS50221; GPS; 1.
PE 4: Predicted;
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000291000};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..29
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 30..5948
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5019444534"
FT TRANSMEM 5550..5570
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 5582..5601
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 5621..5641
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 5653..5678
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 5698..5722
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 5749..5766
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 5772..5797
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT REPEAT 2896..2937
FT /note="EAR"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00075"
FT REPEAT 2938..2986
FT /note="EAR"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00075"
FT REPEAT 2989..3034
FT /note="EAR"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00075"
FT REPEAT 3036..3080
FT /note="EAR"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00075"
FT REPEAT 3082..3129
FT /note="EAR"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00075"
FT REPEAT 3133..3175
FT /note="EAR"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00075"
FT DOMAIN 5547..5798
FT /note="G-protein coupled receptors family 2 profile 2"
FT /evidence="ECO:0000259|PROSITE:PS50261"
FT REGION 5858..5890
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 5914..5933
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 5858..5886
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 5914..5932
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 5948 AA; 650997 MW; A95A94AD5A150275 CRC64;
MSVSPGPGMP SASLLVNLLS ALFIPFVFGE TEIRFAGQTE FVVNETSTTV IRLVVERIGD
PANVTAIVSL YGDDTGDFFD TYAATFIPFG ETNRTVYIAV CDDDFPEPDE TFIFHLTLQK
PSANVKLGWP RTVTVTILSN DNAFGIISFN MPFSITVNEP RGRNESVPLT LIREKGTYGM
VTVTFEVVGG PYPPEEDLSP VKGNITFPPG KATVAYNLTV LDDEVPENDE IFLIQLKSVE
GGAEINTSRS SVEIIVKKND SPVRFIQNVY LVPEEDHILT IPVVRGKDDS GNLIGSDDCE
VSISYVIITG NSTAHAQQNL DFIDLQPNTT IVFPPFIYES HLKFQIVDDA IPEIAESFQV
MLLKDTLRGD AVLLGPSVVQ VTIKPNDKPY GVLSFNSVLF ERTVIIDEDT TTRFEEITVV
RNGGTHGNVS VNWVLTRNSS DPSPVTTDIR PRSGVLHFAQ GQMLASVPLT VINDDLPEEA
EAYLLQILPH TIRGGAEVSE PAELLFYIQD SDDVYGLITF FPVENQKIES SPGERCLSLS
LTRLGGTKGD VKIFYSAFYI PAGAVDPLRA KDGILNISKR SSLIFPEQKT QVTIKLPIRN
DAFLQNGAHF LVQLEAVELV NVVPPIPPIS PRFGEIQNIS LVVTPDIANG EIGFISNLPI
ILHEPEDFAA EVVCISLHRD GTDGQATVHW SLKPSGFNSK AVTLDDIGPF NGSVVFLSGQ
SDTTINITVK ADDIPEMNET VTLSLDRVSV ENQVLKSGYT SRDLIILEND DPGGVFEFSP
ASRGPYIIKE GESVELHIIR HRGALVKQFL HYRIEPRDSN EFYGNTGVLE FKPGEREIVI
TLLTRLDGIP ELDEHYWVVL TSHGERESKL GSATVVNITI LKNDDPHGII EFVSDDLIVT
INESKGDNTY SAIYGVIRNR GNFGDVNVSW VVSPDFTQDV FPVRATIFFG DQEFLKNITI
YSLPDEIPEE MEEFTIILLN ATGGAKIGNK TTATLRIRRN DDPIYFAEPR VVRVREGETA
DFKVLRNGSV DVPCTVQYAT MDGKATAREG DFVPIEKGEM LTFAVGSRQQ NISVFIMEDD
IPETDEPFYI ILFNSTGDTV VYPYAIATVI IEANDDPNGI FSLEPIDKAV EEGKTNSFWI
LRHRGHFGNV SVAWQLFQND SALQPGQEFY ETSGTVNFMD GEGAKPIILH AFPDKIPEFN
EFYILKLVNI SGGSPGPGGQ LAATNLQVTV MIPFNDDPFG VFILDPECLE REVAEDVLSE
DAMSYITNFT VLRQQGAFGD VRVGWEVLSS EFTAGLPPVI DFLLVGVFPS TVHSQPHMRR
HHSGTDALYF SGLEGAFGTV NPKYHPSRNN SIANFTFSAW VMPNANTNGF VIAKDDGNGG
IYYGVKIHTN ESHVTLSLHY KTLGSNATYV AKTTVMKYLE ENVWLHLLIV LDDGIIEFYL
DGNAMPRGIK SLKGEAITDG PGTLRIGAGV NGNDRFTGLM QDVRSYERKL TLEEIYELHA
MPAKSDLHPV SGYLEFRQGE TNKSFIISAR DDNEEEGEEL FILKLVSVYG GARLSEENTT
ARLVIQKSDN ANGLFGFTGS CIPEIAEEGS TVSCVVERTR GALDYVHVFY TISQIESDGV
NYLVDDFANV SGSITFLPWQ RSEVLNIYVL DDDIPELNEY FRVTLVSAIP GDGKIGSTPT
SGASIDPEKE TTDITIKASD HPYGLLQFST GPPPQPEDTM TLPASSVPHV TVQEEDGEVR
LLVVRAQGLL GRVMAEYRTV SLTAFSPEDY QSVAGTLEFQ PGERFKYISV NITDNSIPEL
EKSFKVELLN LEGGVTELFR VDGSGSGDGD MEFFLPANHR RASLGVASQV LVTIAASDHA
HGVFEFSPES LAVSGTEPED GYSTVIFNIM RSHGALSRVI LLWSIDSDPD GDLAFTSGNV
TFEIGQKSAN ITVEILPDED PELDKTFSVT ILSVSSGSLG VHTNATLIVL ASDDPYGVFI
FSEKNRPIKV EEATQNITLS IIRLKGLLGK VKVTYATLDD MEKPPHFPPN LARATQGKDY
IPASGFAVFR ANQSEATITV SVLDDDEPER SESLFVELLN STLTEKVQNR PIPNSPRLGS
KVEAIAQLII IANDDAFGIL QLSAPVVRVA ENHVGPIINV TRTGGAFADV SVKFKAVPIT
AVAGEDYSIA SSDVVLLEGE TSKVVPIYVI NDIYPELEES FLVQLLNETT GGAKLGALTE
AIIFIEASDD PYGLFGFQIT KLTVEEPEFN SVKVNLPIIR NSGTLGNVTV QWVATINGQL
ATGDLRVVSG ETKKVAILTI LDDSEPEDDE IIVVSLVYTE GGSRILPSSD TVRVNILAND
NVAGVVSFQT ASRSVIGHEG ETLQFHVIRT PPGRGNVTVN WKIIGQNLEL NFANSTGQLF
FPEGSLNKII SVHLLDDNIP EEKEVYQVIL YDVRTQGVSP AGAALLDAQG YAAVLTVEAS
DEPHGVLNFA LSSRFVLLQE ANTTIKLFIN REFGSLGAIN VTYATVPGML SRKNQTEGNL
AEPDVDFVPV VGFLILEEGE TAGAIDITIL EDDIPELEEC FLVNLTHVEL IMAPFTSFPP
RLDSEGLTAQ IIIDANDGAR GVIEWQLSRF EVNETQGSLT LVAQRRTGAL GPVSLLVYAQ
NLEAQLGVDY AFTPMILHFA NGERHKNVDI MILDDDIPEG DEAFQLILTN PSSGLELGEN
IVAFITILAN DDGPGVLSFN NSEHFFLREP TAVYVQESMA VLYVVREPAQ GLFGTVTVQF
IVTEVNSSVE SKDLAPSKGY VVLEEGVRFK ALHIFAILDT EPEMDEHFVC TLFNPTGGAR
LGAHVQTLIT ILQNQAPLGL FSISAVANRG TSVNIEEANR TVYLSVSRTN GIDLAVSVEW
ETVSETAFGM RGMDVTFSTF QSFLDASASG WCFFTLEDSV HGLMLRKLSS TLYRWQGIFV
PFEDLSIENP KTCEAFNIGL SSYFVITHEE RNKEKSSVNS VYMFTSGFKL FLVQTINISE
SSQVRYFTSD SQDYLIVASQ SDDSQLTQVF RWNGGSFVWH QTLSVRGVLS MALFTRGGTV
FLAIAQANAR SNSLLLRWSS NEFTNFQEVP ISGTTQVEAL TSGDDIYLIF VKTIFLGDQN
SVDIFVWEAG QSSFRYFQSL DFAAVNKIHS FTPASGIVHL LLLGQAVSAL YCWNSELNHF
SLLLEAPSAS DAAFVTVKSL NSSKNLIALA GATHSHIYEL AYVSSQSDFI PSSGELIFEP
GDKEAIIAVN VLDDTVPEED ESFRVQLKNP KGGAEIGING YVQITILSND DAYGVVGFAQ
NSLYKQVEEM EQDSLLTLNV ERLKGTYGRI TVAWEADGSI SDIFPTSGVI SFSEGQALST
ITLTVLADDL PELSEIVIVT LIRIITEGVE DPSKGATIDQ KRNKSVITTL PNDSPYGLVG
WHAESLFIKV AEPKENVTAL QLQIVRDKGL LGDIAIQLVA KPNFLLHINN QATENEDYVL
QETMIIMKEN IKETYVKVAI LPDDVPELEE GFIVSITEVR LVNSDFSAGQ PSVQRPGLEM
AEIMIEENDD PRGIFKFHIT RDVAVITAYE VPPPMNVLQV PVVRLAGSFG EVKVYWKATV
DSAGLEDFKP SHGILEFADR QVIAVIEITI IDDDEFELME MFNISLIKVA GGGRLGDDVV
VTVVIPQNDS PFGVFGFEEK TVMVDESLLS DDPDSYVTLT VVRSPGGKGA VRLQWTIDEM
AKDDLSPLSG TLHFDETDSQ KTIVLHTLQD ATLEEDRRFT IQLLSVDEVE ISPVKGSASI
IIRGDKGASG EVGIAPSSRH VLIGEPSAKY NGTAIISLIR GPAISGEVTV SWRIVPPSLE
EFAETSGKLT MRDGQSAAIV VIQALNDDLP EEKRFYEFQL TGVSEGGVLS ESSTTANITM
VASDFPYGRF AFSQEQLRVT EEVQKVNLTV IRSGGSFGRV RLCLEAVSGT AEVGVDFLPP
PVQLLFEARE TVKSVHIEIL DDSLPEGPEE FSLVMTDVEL LGRGYDFTIQ ENGLQIDQPP
EIGNISIVRI IIMKNDNAEG IIEFDPRYTT FEVEEDIGTI MIPVQRLHGA YGRVTADLVS
QSSSAVPGGV DYVLHGSSVT FQHGQNLSFI NVSIIDDDES EFEEPIEIML VGATGGAVLG
RHLVCRITIA KSDSPFGVIR FLNQSRVSVP NPSSTVILPL MLERTGGLLG EIQVNWEIVG
PNSQEALPSQ NQDIADPVSG SFSFGDGEGG VRSIILGIYP HDDIEIEKTF IIKLKLVKGE
AQLDSTAKDI TLTIEKFGDP NGVIQFAPES LSEETYLEPS TLEGPLIITF FVRRIKGVSG
EIMVYWELSS EFDITGDFLS TKGIFTIADG DSEASFDVHL LPDDIPEIEE VYVLQLVSVK
GGAKLDTEKC VIRFSVSAND DPHGIFALYS DHQSVLIGQN LRRLIQINVT RLAGTFGDVA
VRYRISSDSK AQSVVTENAE RQLVVRDGTR YKVDSVPVQG QVFLPLGSNF TLQLVTVMLV
GGSFYGVPKI LQEAKSAMLP VPEKAANSQV GFESTAFPLT DIAAGTSQAV ISRRGTYGSL
KVSWAAGYVP GSGIPEFTAV GNMTPKVGRL SFSHGEESRR ALLWTHPSPG RLEAFVIHLF
GVQSSVPGGA QLRSGFTVAE IEPMGVFQFS PSSRNIIVSE DTQMIRLHVQ RLFGFHGELI
KVSYQTTAGR AKPQEDFEAV QNGELLFGKF QVEVDFEIII IDDELPEIEE IFYINLTSVE
IKGLPKFDAN WRPRLNRDFS VAVITILDND DLAGTDTSFT KTAVTTAVNT ALPLETDSAT
THPDTTEITA IPQPTEVVAM VTEVAGVSPI PEDLVTLAGT SAMSEKPNAA TVTTDTSVHG
TFSLGPPVVY VEEEMENGTL NAAEVLVRRT GGSAGNVSVT VRTFGETSAQ KEPNALPFPD
SHRISNLTWA TEEEDFGAQT LILAFVDGER ERKVSIPILD DGDPEGQEFF YVFLTDPQGG
AQIVKGEDDA GFAAFAMIVI TGSDLHNGII GFSEESQSRL ELGEETEMSS LRLTVTRQPN
RAFEDVKVFW RVTFNKTAAV LQKDGVSLVD QLLSVAGTTV CMAGQTKGLI TIELKPGKIP
QSEIDFFVEL YEVTAGAALN NSARFAQIKL LQREKPPSLV YFSVGSRLPV AHKKATLISL
QVAREYGAGL VMSVNFSTQE LRSSETIGRT LISPAISGKD FVRTEGTLIF EPGQRTTVLD
VILTPETGSL NPFPKRFQIV LFDPRGGAGV DKVYGTANIT LVSDTNSQAF WGLADQLQQP
LDGDILNRVL HSVSVKVATE NTDEQLSAVL YLIDKITIEG KQQALSIESR NLFYEILCAL
VNPKRKDTRG FSHFTEVTEN FAFSLLTDVT CGSPGEKGKT ILDSCPYLSI LALHWYPQQI
NGHKFEGKEG DYIRVPERLL DVLDAEIMAG RSTCELVQFT EYSSQQWFMT GNNFHALKNK
VLSLSVKGQS SQPLTNSNEI LYRIYAAEPR IVPKTPLCLL WNPSAASWLS DSQFCKVVED
TSGYVECACS YMSVYAVYAQ TDNLSSYNEA FFSSGFICIS GLCLAVLSHI FCARYSMFAA
KLLTHMLAAS LGTQIVFLAS AYASPQLTEE SCSAIAAVTH YLYLCQFSWM LIQSVNFWYV
LVMNDEHTER RYLLFLLLSW GLPALVVILL IVVLRAVYHQ SMPQIYGLIH SDLCFIPNVY
AALFTAALVP VTCLVVVFVV FTHAYQVKPQ WRAYDDVFRG RTNAAEIPLV LYLFALISMT
WLWGGLHMAY RHFWMLVLFV IFNSLQGLYV FVVYFILHNQ TCCPMKASYT VEMNGHPGPS
TTFFTPGSGM PAAGGEISKS TQNLISAMEE VPPDWERTSF QQASQASPDL KPSPQNGATF
PSSGGYGQGS LVADEESQEF DDLIFALKTG AGLSVSDNES GQGSQEGGTL TDSQIVELRR
IPIADTHL
//
