ID A0A452G552_CAPHI Unreviewed; 228 AA.
AC A0A452G552;
DT 08-MAY-2019, integrated into UniProtKB/TrEMBL.
DT 08-MAY-2019, sequence version 1.
DT 27-MAR-2024, entry version 26.
DE RecName: Full=Toll/interleukin-1 receptor domain-containing adapter protein {ECO:0000256|PIRNR:PIRNR037750};
DE Short=TIR domain-containing adapter protein {ECO:0000256|PIRNR:PIRNR037750};
GN Name=TIRAP {ECO:0000313|Ensembl:ENSCHIP00000031677.1};
OS Capra hircus (Goat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC Caprinae; Capra.
OX NCBI_TaxID=9925 {ECO:0000313|Ensembl:ENSCHIP00000031677.1, ECO:0000313|Proteomes:UP000291000};
RN [1] {ECO:0000313|Ensembl:ENSCHIP00000031677.1, ECO:0000313|Proteomes:UP000291000}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Bickhart D.M., Koren S., Rosen B., Hastie A., Liachko I., Sullivan S.T.,
RA Burton J., Sayre B.L., Huson H.J., Lee J., Lam E., Kelley C.M.,
RA Hutchison J.L., Zhou Y., Sun J., Crisa A., Schwartz J.C., Hammond J.A.,
RA Schroeder S.G., Liu G.E., Dunham M., Shendure J., Sonstegard T.S.,
RA Phillippy A.M., Van Tassell C.P., Smith T.P.;
RT "Polished mammalian reference genomes with single-molecule sequencing and
RT chromosome conformation capture applied to the Capra hircus genome.";
RL Submitted (APR-2016) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSCHIP00000031677.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- FUNCTION: Adapter involved in the TLR2 and TLR4 signaling pathways in
CC the innate immune response. {ECO:0000256|PIRNR:PIRNR037750}.
CC -!- SUBUNIT: Homodimer. {ECO:0000256|PIRNR:PIRNR037750}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|PIRNR:PIRNR037750}. Cell
CC membrane {ECO:0000256|PIRNR:PIRNR037750}. Membrane
CC {ECO:0000256|PIRNR:PIRNR037750}.
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DR EMBL; LWLT01000026; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_017898791.1; XM_018043302.1.
DR RefSeq; XP_017898792.1; XM_018043303.1.
DR RefSeq; XP_017898793.1; XM_018043304.1.
DR RefSeq; XP_017898794.1; XM_018043305.1.
DR AlphaFoldDB; A0A452G552; -.
DR STRING; 9925.ENSCHIP00000031677; -.
DR Ensembl; ENSCHIT00000039551.1; ENSCHIP00000031677.1; ENSCHIG00000025937.1.
DR GeneID; 102184789; -.
DR KEGG; chx:102184789; -.
DR CTD; 114609; -.
DR GeneTree; ENSGT00510000048428; -.
DR OMA; RWKRKYD; -.
DR OrthoDB; 5392575at2759; -.
DR Proteomes; UP000291000; Chromosome 29.
DR Bgee; ENSCHIG00000025937; Expressed in spleen and 16 other cell types or tissues.
DR GO; GO:0009986; C:cell surface; IEA:Ensembl.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0031234; C:extrinsic component of cytoplasmic side of plasma membrane; IEA:Ensembl.
DR GO; GO:0042802; F:identical protein binding; IEA:UniProtKB-UniRule.
DR GO; GO:0005080; F:protein kinase C binding; IEA:Ensembl.
DR GO; GO:0035591; F:signaling adaptor activity; IEA:Ensembl.
DR GO; GO:0035663; F:Toll-like receptor 2 binding; IEA:UniProtKB-UniRule.
DR GO; GO:0035662; F:Toll-like receptor 4 binding; IEA:UniProtKB-UniRule.
DR GO; GO:0070935; P:3'-UTR-mediated mRNA stabilization; IEA:Ensembl.
DR GO; GO:0006954; P:inflammatory response; IEA:UniProtKB-KW.
DR GO; GO:0045087; P:innate immune response; IEA:UniProtKB-KW.
DR GO; GO:0043123; P:positive regulation of canonical NF-kappaB signal transduction; IEA:Ensembl.
DR GO; GO:0070374; P:positive regulation of ERK1 and ERK2 cascade; IEA:Ensembl.
DR GO; GO:0032738; P:positive regulation of interleukin-15 production; IEA:Ensembl.
DR GO; GO:0032755; P:positive regulation of interleukin-6 production; IEA:Ensembl.
DR GO; GO:0032757; P:positive regulation of interleukin-8 production; IEA:Ensembl.
DR GO; GO:0046330; P:positive regulation of JNK cascade; IEA:Ensembl.
DR GO; GO:0031334; P:positive regulation of protein-containing complex assembly; IEA:Ensembl.
DR GO; GO:0034137; P:positive regulation of toll-like receptor 2 signaling pathway; IEA:Ensembl.
DR GO; GO:0034145; P:positive regulation of toll-like receptor 4 signaling pathway; IEA:Ensembl.
DR GO; GO:0032760; P:positive regulation of tumor necrosis factor production; IEA:Ensembl.
DR GO; GO:0032496; P:response to lipopolysaccharide; IEA:Ensembl.
DR GO; GO:0035665; P:TIRAP-dependent toll-like receptor 4 signaling pathway; IEA:Ensembl.
DR Gene3D; 3.40.50.10140; Toll/interleukin-1 receptor homology (TIR) domain; 1.
DR InterPro; IPR000157; TIR_dom.
DR InterPro; IPR017279; Tol-interleuk_rcpt_adapt_Tirap.
DR InterPro; IPR035897; Toll_tir_struct_dom_sf.
DR PANTHER; PTHR22662; TIRAP; 1.
DR PANTHER; PTHR22662:SF0; TOLL_INTERLEUKIN-1 RECEPTOR DOMAIN-CONTAINING ADAPTER PROTEIN; 1.
DR Pfam; PF13676; TIR_2; 1.
DR PIRSF; PIRSF037750; TIR_Tirap; 1.
DR SUPFAM; SSF52200; Toll/Interleukin receptor TIR domain; 1.
DR PROSITE; PS50104; TIR; 1.
PE 4: Predicted;
KW Cell membrane {ECO:0000256|PIRNR:PIRNR037750};
KW Cytoplasm {ECO:0000256|PIRNR:PIRNR037750};
KW Immunity {ECO:0000256|PIRNR:PIRNR037750};
KW Inflammatory response {ECO:0000256|PIRNR:PIRNR037750};
KW Innate immunity {ECO:0000256|PIRNR:PIRNR037750};
KW Membrane {ECO:0000256|PIRNR:PIRNR037750};
KW Reference proteome {ECO:0000313|Proteomes:UP000291000}.
FT DOMAIN 91..220
FT /note="TIR"
FT /evidence="ECO:0000259|PROSITE:PS50104"
FT REGION 1..86
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 41..61
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 69..86
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 228 AA; 24184 MW; 824BA96C176811CE CRC64;
MASSTSSPAP GSRSKKPLGK MADWFRQALS RKPTKMPASP ESALSDVSQP SSLDSPPSLG
PSSEVSPIPT PSPGGASGGS GSSSSNGRWS KAYDVCVCHS EEDLVAAQEL VSYLEGGAAS
LRCFLQLRDA TPGGAIVSEL CHALSSSHCR VLLITPGFLR DPWCRYQMLQ ALSEAPGAEG
RTIPLMSGLS RAAYPAELRY MYFVDGRGPE RGFRQVKDAV MRYLQTLG
//
