ID A0A452G585_CAPHI Unreviewed; 552 AA.
AC A0A452G585;
DT 08-MAY-2019, integrated into UniProtKB/TrEMBL.
DT 08-MAY-2019, sequence version 1.
DT 27-MAR-2024, entry version 24.
DE SubName: Full=Interleukin 1 receptor like 2 {ECO:0000313|Ensembl:ENSCHIP00000031714.1};
GN Name=IL1RL2 {ECO:0000313|Ensembl:ENSCHIP00000031714.1};
OS Capra hircus (Goat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC Caprinae; Capra.
OX NCBI_TaxID=9925 {ECO:0000313|Ensembl:ENSCHIP00000031714.1, ECO:0000313|Proteomes:UP000291000};
RN [1] {ECO:0000313|Ensembl:ENSCHIP00000031714.1, ECO:0000313|Proteomes:UP000291000}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Bickhart D.M., Koren S., Rosen B., Hastie A., Liachko I., Sullivan S.T.,
RA Burton J., Sayre B.L., Huson H.J., Lee J., Lam E., Kelley C.M.,
RA Hutchison J.L., Zhou Y., Sun J., Crisa A., Schwartz J.C., Hammond J.A.,
RA Schroeder S.G., Liu G.E., Dunham M., Shendure J., Sonstegard T.S.,
RA Phillippy A.M., Van Tassell C.P., Smith T.P.;
RT "Polished mammalian reference genomes with single-molecule sequencing and
RT chromosome conformation capture applied to the Capra hircus genome.";
RL Submitted (APR-2016) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSCHIP00000031714.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the interleukin-1 receptor family.
CC {ECO:0000256|ARBA:ARBA00009752}.
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DR EMBL; LWLT01000009; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_013822917.2; XM_013967463.2.
DR RefSeq; XP_013822918.2; XM_013967464.2.
DR RefSeq; XP_013822919.2; XM_013967465.2.
DR RefSeq; XP_013822920.2; XM_013967466.2.
DR AlphaFoldDB; A0A452G585; -.
DR STRING; 9925.ENSCHIP00000031714; -.
DR Ensembl; ENSCHIT00000039588.1; ENSCHIP00000031714.1; ENSCHIG00000025961.1.
DR GeneID; 102188053; -.
DR CTD; 8808; -.
DR GeneTree; ENSGT01090000259985; -.
DR OMA; CHLNFPQ; -.
DR OrthoDB; 4322253at2759; -.
DR Proteomes; UP000291000; Chromosome 11.
DR Bgee; ENSCHIG00000025961; Expressed in rumen and 3 other cell types or tissues.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.
DR GO; GO:0004909; F:interleukin-1, type I, activating receptor activity; IEA:InterPro.
DR GO; GO:0032755; P:positive regulation of interleukin-6 production; IEA:Ensembl.
DR GO; GO:0045582; P:positive regulation of T cell differentiation; IEA:Ensembl.
DR GO; GO:0050727; P:regulation of inflammatory response; IEA:Ensembl.
DR CDD; cd05757; Ig2_IL1R-like; 1.
DR Gene3D; 2.60.40.10; Immunoglobulins; 3.
DR Gene3D; 3.40.50.10140; Toll/interleukin-1 receptor homology (TIR) domain; 1.
DR InterPro; IPR007110; Ig-like_dom.
DR InterPro; IPR036179; Ig-like_dom_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR003599; Ig_sub.
DR InterPro; IPR003598; Ig_sub2.
DR InterPro; IPR015621; IL-1_rcpt_fam.
DR InterPro; IPR004076; IL-1_rcpt_I-typ.
DR InterPro; IPR004074; IL-1_rcpt_I/II-typ.
DR InterPro; IPR013151; Immunoglobulin.
DR InterPro; IPR000157; TIR_dom.
DR InterPro; IPR035897; Toll_tir_struct_dom_sf.
DR PANTHER; PTHR11890; INTERLEUKIN-1 RECEPTOR FAMILY MEMBER; 1.
DR PANTHER; PTHR11890:SF9; INTERLEUKIN-1 RECEPTOR-LIKE 2; 1.
DR Pfam; PF00047; ig; 1.
DR Pfam; PF13895; Ig_2; 1.
DR Pfam; PF01582; TIR; 1.
DR PRINTS; PR01538; INTRLEUKN1R1.
DR PRINTS; PR01536; INTRLKN1R12F.
DR PRINTS; PR01537; INTRLKN1R1F.
DR SMART; SM00409; IG; 3.
DR SMART; SM00408; IGc2; 2.
DR SMART; SM00255; TIR; 1.
DR SUPFAM; SSF48726; Immunoglobulin; 3.
DR SUPFAM; SSF52200; Toll/Interleukin receptor TIR domain; 1.
DR PROSITE; PS50835; IG_LIKE; 2.
DR PROSITE; PS50104; TIR; 1.
PE 3: Inferred from homology;
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Immunoglobulin domain {ECO:0000256|ARBA:ARBA00023319};
KW Membrane {ECO:0000256|SAM:Phobius}; NAD {ECO:0000256|ARBA:ARBA00023027};
KW Reference proteome {ECO:0000313|Proteomes:UP000291000};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..19
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 20..552
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5019395705"
FT TRANSMEM 335..358
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 14..110
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 128..214
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 380..535
FT /note="TIR"
FT /evidence="ECO:0000259|PROSITE:PS50104"
SQ SEQUENCE 552 AA; 63053 MW; 7F5A0963413FFBC6 CRC64;
MLSLLLCVVS IALPRFIRAD ACEDLTLQEM ASVDQPTAFN CIYSLPTSGK ADATWYKYPS
KIPISKNTQS RIYQNQNWIL FLPVKGEDSG IYQCLTNDTD ICPRMRVNLT VFEKYWCGAS
GNSQLNVPHE YKQILQVGRD DILMCHLNFP NNFYLDSVKW YKDCIEIEGE RFISRGKKLL
VKNVSVEDRG NYECQASLTH AKKQHTVFNS ISVTVTEKVG SGGRIPKIIY PKNNSIEVKL
GSMLIVNCNI TDTRDNTNPR CWRVNNTLVD DYYGESKRIQ EGIENYTIFP EHIFYTVNIT
FLEVKMEDYG RPFMCHAGVS AAFFILKLPV PDFQAYLIGG LLILTGAVVS AMCIYNIFKI
DIVLWYRSSF HSAGPIEDGK LYDAYVLYPK PQRESQSHDV DTLVLKILPE VLEKQCGYKL
FIFGRDEFPG QAVVNVIDEN IRLCRRLIII IDPDELSFDL LKNLSEEQIA VYSALIQDGI
KVILIELGKV KDYTALPESI QYIKQKHGAV QWSGDFTEQS QCAKTKFWKK VRYHMPPKRW
PPSCPAAEVH AL
//
