ID A0A452G596_CAPHI Unreviewed; 699 AA.
AC A0A452G596;
DT 08-MAY-2019, integrated into UniProtKB/TrEMBL.
DT 08-MAY-2019, sequence version 1.
DT 24-JAN-2024, entry version 22.
DE SubName: Full=UV radiation resistance associated {ECO:0000313|Ensembl:ENSCHIP00000031753.1};
GN Name=UVRAG {ECO:0000313|Ensembl:ENSCHIP00000031753.1};
OS Capra hircus (Goat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC Caprinae; Capra.
OX NCBI_TaxID=9925 {ECO:0000313|Ensembl:ENSCHIP00000031753.1, ECO:0000313|Proteomes:UP000291000};
RN [1] {ECO:0000313|Ensembl:ENSCHIP00000031753.1, ECO:0000313|Proteomes:UP000291000}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Bickhart D.M., Koren S., Rosen B., Hastie A., Liachko I., Sullivan S.T.,
RA Burton J., Sayre B.L., Huson H.J., Lee J., Lam E., Kelley C.M.,
RA Hutchison J.L., Zhou Y., Sun J., Crisa A., Schwartz J.C., Hammond J.A.,
RA Schroeder S.G., Liu G.E., Dunham M., Shendure J., Sonstegard T.S.,
RA Phillippy A.M., Van Tassell C.P., Smith T.P.;
RT "Polished mammalian reference genomes with single-molecule sequencing and
RT chromosome conformation capture applied to the Capra hircus genome.";
RL Submitted (APR-2016) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSCHIP00000031753.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
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DR EMBL; LWLT01000015; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_017914818.1; XM_018059329.1.
DR AlphaFoldDB; A0A452G596; -.
DR STRING; 9925.ENSCHIP00000031753; -.
DR Ensembl; ENSCHIT00000039627.1; ENSCHIP00000031753.1; ENSCHIG00000025967.1.
DR GeneID; 102174861; -.
DR KEGG; chx:102174861; -.
DR CTD; 7405; -.
DR GeneTree; ENSGT00390000012877; -.
DR OrthoDB; 5481315at2759; -.
DR Proteomes; UP000291000; Chromosome 15.
DR Bgee; ENSCHIG00000025967; Expressed in cerebellum and 18 other cell types or tissues.
DR GO; GO:0000421; C:autophagosome membrane; IEA:Ensembl.
DR GO; GO:0005813; C:centrosome; IEA:Ensembl.
DR GO; GO:0070418; C:DNA-dependent protein kinase complex; IEA:Ensembl.
DR GO; GO:0005769; C:early endosome; IEA:Ensembl.
DR GO; GO:0005783; C:endoplasmic reticulum; IEA:Ensembl.
DR GO; GO:0005770; C:late endosome; IEA:Ensembl.
DR GO; GO:0005764; C:lysosome; IEA:Ensembl.
DR GO; GO:0030496; C:midbody; IEA:Ensembl.
DR GO; GO:0045335; C:phagocytic vesicle; IEA:Ensembl.
DR GO; GO:0035032; C:phosphatidylinositol 3-kinase complex, class III; IEA:Ensembl.
DR GO; GO:0017124; F:SH3 domain binding; IEA:Ensembl.
DR GO; GO:0000149; F:SNARE binding; IEA:Ensembl.
DR GO; GO:0097352; P:autophagosome maturation; IEA:Ensembl.
DR GO; GO:0007098; P:centrosome cycle; IEA:Ensembl.
DR GO; GO:0007059; P:chromosome segregation; IEA:Ensembl.
DR GO; GO:0097680; P:double-strand break repair via classical nonhomologous end joining; IEA:Ensembl.
DR GO; GO:0051684; P:maintenance of Golgi location; IEA:Ensembl.
DR GO; GO:0036092; P:phosphatidylinositol-3-phosphate biosynthetic process; IEA:Ensembl.
DR GO; GO:0032801; P:receptor catabolic process; IEA:Ensembl.
DR GO; GO:0010506; P:regulation of autophagy; IEA:Ensembl.
DR GO; GO:0032465; P:regulation of cytokinesis; IEA:Ensembl.
DR GO; GO:0006890; P:retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum; IEA:Ensembl.
DR GO; GO:0035493; P:SNARE complex assembly; IEA:Ensembl.
DR GO; GO:0007051; P:spindle organization; IEA:Ensembl.
DR GO; GO:0046718; P:viral entry into host cell; IEA:Ensembl.
DR CDD; cd00030; C2; 1.
DR Gene3D; 2.60.40.150; C2 domain; 1.
DR InterPro; IPR000008; C2_dom.
DR InterPro; IPR035892; C2_domain_sf.
DR InterPro; IPR018791; UV_resistance/autophagy_Atg14.
DR PANTHER; PTHR15157; UV RADIATION RESISTANCE-ASSOCIATED GENE PROTEIN; 1.
DR PANTHER; PTHR15157:SF5; UV RADIATION RESISTANCE-ASSOCIATED GENE PROTEIN; 1.
DR Pfam; PF10186; ATG14; 1.
DR SMART; SM00239; C2; 1.
DR SUPFAM; SSF49562; C2 domain (Calcium/lipid-binding domain, CaLB); 1.
DR PROSITE; PS50004; C2; 1.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054, ECO:0000256|SAM:Coils};
KW Reference proteome {ECO:0000313|Proteomes:UP000291000}.
FT DOMAIN 23..149
FT /note="C2"
FT /evidence="ECO:0000259|PROSITE:PS50004"
FT REGION 1..20
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 486..613
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 237..306
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 513..555
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 574..613
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 699 AA; 77881 MW; 95F5537BBC4E6C92 CRC64;
MNASASVGGP LPPPPTGPAA ALPPGSAARA LHVELPSQQR RLRHLRNIAA RNIVNRNGHQ
LLDTYFTLHL CNTEKVFKEF YRSEVIKNSL NPTWRSLDFG IIPDRLDTSV SCFVVKIWGG
KEDIYQLLIE WKVCLDGLKY LGQQIHARNQ NEIIFGLNDG YYGAPFEHKG YSNAQKNILL
QVDQNCVRNS YDVFSLLRLH RAQCAIKQTQ VTVQKIGKEI EEKLRLTSTS NGLKKESECL
QLKILVLRNE LERQKKALGR EAVLLHKEQI ALQDKGSTFS AEHLKLQLQK ESLNELRKEC
TAKRELFLKT NAQLTIRCRQ LLSELSYIYP IDLNDHKDYF VCGVKLPNSE DFQAKDDGSI
AVALGYTAHL VSMISFFLQV PLRYPVIHKG SRSTIKDNIN DKLTEKEREF PLYPKGGEKL
QFDYGVYLLN KNIAQLRYQH GLGTPDLRQT LPNLKNFMEH GLMVRCDRHH TSSAIPVPKR
QSSIFGGADV GFSGGIPSPD KGYRKRASSE NERLQYKTPP PSYNSALVQP VTPVPSTGES
DRKTASLSSS LDTSLDLSKE NKKKGVDLGD SLNGGHMSVN TSQEQGQALS GPPATINGTL
LPGEQASSSG AQLPGGFHPV SEAELCCTVE QAEEIIGMEA TGFTSGDQLE AFNCIPVDSA
VAVECDEQVL GEFEEFSRRI YALNENVSSF RRPRRSSDK
//
