ID A0A452G5T3_CAPHI Unreviewed; 453 AA.
AC A0A452G5T3;
DT 08-MAY-2019, integrated into UniProtKB/TrEMBL.
DT 08-MAY-2019, sequence version 1.
DT 27-MAR-2024, entry version 19.
DE SubName: Full=Growth factor receptor bound protein 14 {ECO:0000313|Ensembl:ENSCHIP00000031919.1};
GN Name=GRB14 {ECO:0000313|Ensembl:ENSCHIP00000031919.1};
OS Capra hircus (Goat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC Caprinae; Capra.
OX NCBI_TaxID=9925 {ECO:0000313|Ensembl:ENSCHIP00000031919.1, ECO:0000313|Proteomes:UP000291000};
RN [1] {ECO:0000313|Ensembl:ENSCHIP00000031919.1, ECO:0000313|Proteomes:UP000291000}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Bickhart D.M., Koren S., Rosen B., Hastie A., Liachko I., Sullivan S.T.,
RA Burton J., Sayre B.L., Huson H.J., Lee J., Lam E., Kelley C.M.,
RA Hutchison J.L., Zhou Y., Sun J., Crisa A., Schwartz J.C., Hammond J.A.,
RA Schroeder S.G., Liu G.E., Dunham M., Shendure J., Sonstegard T.S.,
RA Phillippy A.M., Van Tassell C.P., Smith T.P.;
RT "Polished mammalian reference genomes with single-molecule sequencing and
RT chromosome conformation capture applied to the Capra hircus genome.";
RL Submitted (APR-2016) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSCHIP00000031919.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the GRB7/10/14 family.
CC {ECO:0000256|ARBA:ARBA00006708}.
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DR EMBL; LWLT01000002; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_017919419.1; XM_018063930.1.
DR AlphaFoldDB; A0A452G5T3; -.
DR Ensembl; ENSCHIT00000039794.1; ENSCHIP00000031919.1; ENSCHIG00000026062.1.
DR GeneID; 100861137; -.
DR CTD; 2888; -.
DR GeneTree; ENSGT00940000158609; -.
DR OMA; EDDGAMF; -.
DR OrthoDB; 3144731at2759; -.
DR Proteomes; UP000291000; Chromosome 2.
DR Bgee; ENSCHIG00000026062; Expressed in ovary and 17 other cell types or tissues.
DR GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR CDD; cd01259; PH_APBB1IP; 1.
DR CDD; cd16139; RA_GRB14; 1.
DR CDD; cd10414; SH2_Grb14; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR Gene3D; 3.30.505.10; SH2 domain; 1.
DR InterPro; IPR015042; BPS-dom.
DR InterPro; IPR039664; GRB/APBB1IP.
DR InterPro; IPR035034; Grb14_SH2.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR039665; PH_APBB1IP.
DR InterPro; IPR001849; PH_domain.
DR InterPro; IPR000159; RA_dom.
DR InterPro; IPR000980; SH2.
DR InterPro; IPR036860; SH2_dom_sf.
DR InterPro; IPR029071; Ubiquitin-like_domsf.
DR PANTHER; PTHR11243; GROWTH FACTOR RECEPTOR-BOUND PROTEIN; 1.
DR PANTHER; PTHR11243:SF22; GROWTH FACTOR RECEPTOR-BOUND PROTEIN 14; 1.
DR Pfam; PF08947; BPS; 1.
DR Pfam; PF00169; PH; 1.
DR Pfam; PF00788; RA; 1.
DR Pfam; PF00017; SH2; 1.
DR PRINTS; PR00401; SH2DOMAIN.
DR SMART; SM00233; PH; 1.
DR SMART; SM00314; RA; 1.
DR SMART; SM00252; SH2; 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR SUPFAM; SSF55550; SH2 domain; 1.
DR SUPFAM; SSF54236; Ubiquitin-like; 1.
DR PROSITE; PS50003; PH_DOMAIN; 1.
DR PROSITE; PS50200; RA; 1.
DR PROSITE; PS50001; SH2; 1.
PE 3: Inferred from homology;
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP000291000};
KW SH2 domain {ECO:0000256|ARBA:ARBA00022999, ECO:0000256|PROSITE-
KW ProRule:PRU00191}.
FT DOMAIN 19..105
FT /note="Ras-associating"
FT /evidence="ECO:0000259|PROSITE:PS50200"
FT DOMAIN 147..255
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT DOMAIN 352..448
FT /note="SH2"
FT /evidence="ECO:0000259|PROSITE:PS50001"
SQ SEQUENCE 453 AA; 51977 MW; CB5C3BF83EBA10B6 CRC64;
MSLSARRVTL PAITPIVLQK RVIKVYSEDE TSRALEVPSD ITARDVCQLL ILKNHYIDDH
SWTLFEHLPH VGLERTIEDH ELVIEVLSNW GMEEENKLYF RKNYAKYEFF KNPMYFFPEH
MVSFATETNG EISPTQILQM FLSSSTYPEI HGFLHAKEQG KKSWKKIYFL LRRSGLYFST
KGTSKEPRHL QFFSEFGNSD IYVSLAGKKK HGAPTNYGFC FKPNKAGGPR DLKMLCAEEE
QSRTCWVTAI RLLKYGMQLY QNYMHPYQGR SGYSSQSISP MRSISENSLV AMDFSGQKTR
VIENPTEALS VAVEEGLAWR KKGCLRLGSH GSPTASSQSS ATSMAIHRSQ PWFHHKISRE
EAQRLIIQQG LVDGVFLVRD SQSNPKTFVL SMSHGQKIKH FQIIPVEDDG EMFHTLDDGH
TRFTDLIQLV EFYQLNKGVL PCKLKHYCAR IAL
//
