ID A0A452G9Z6_CAPHI Unreviewed; 2785 AA.
AC A0A452G9Z6;
DT 08-MAY-2019, integrated into UniProtKB/TrEMBL.
DT 08-MAY-2019, sequence version 1.
DT 27-MAR-2024, entry version 24.
DE SubName: Full=Teneurin transmembrane protein 4 {ECO:0000313|Ensembl:ENSCHIP00000033459.1};
GN Name=TENM4 {ECO:0000313|Ensembl:ENSCHIP00000033459.1};
OS Capra hircus (Goat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC Caprinae; Capra.
OX NCBI_TaxID=9925 {ECO:0000313|Ensembl:ENSCHIP00000033459.1, ECO:0000313|Proteomes:UP000291000};
RN [1] {ECO:0000313|Ensembl:ENSCHIP00000033459.1, ECO:0000313|Proteomes:UP000291000}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Bickhart D.M., Koren S., Rosen B., Hastie A., Liachko I., Sullivan S.T.,
RA Burton J., Sayre B.L., Huson H.J., Lee J., Lam E., Kelley C.M.,
RA Hutchison J.L., Zhou Y., Sun J., Crisa A., Schwartz J.C., Hammond J.A.,
RA Schroeder S.G., Liu G.E., Dunham M., Shendure J., Sonstegard T.S.,
RA Phillippy A.M., Van Tassell C.P., Smith T.P.;
RT "Polished mammalian reference genomes with single-molecule sequencing and
RT chromosome conformation capture applied to the Capra hircus genome.";
RL Submitted (APR-2016) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSCHIP00000033459.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004162};
CC Single-pass membrane protein {ECO:0000256|ARBA:ARBA00004162}. Membrane
CC {ECO:0000256|ARBA:ARBA00004167}; Single-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004167}.
CC -!- SIMILARITY: Belongs to the tenascin family. Teneurin subfamily.
CC {ECO:0000256|ARBA:ARBA00009385}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00076}.
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DR EMBL; LWLT01000026; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR Ensembl; ENSCHIT00000041338.1; ENSCHIP00000033459.1; ENSCHIG00000026998.1.
DR GeneTree; ENSGT01030000234566; -.
DR Proteomes; UP000291000; Chromosome 29.
DR Bgee; ENSCHIG00000026998; Expressed in frontal cortex and 17 other cell types or tissues.
DR GO; GO:0042995; C:cell projection; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0007155; P:cell adhesion; IEA:UniProtKB-KW.
DR GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR CDD; cd00054; EGF_CA; 1.
DR Gene3D; 2.10.25.10; Laminin; 7.
DR Gene3D; 2.180.10.10; RHS repeat-associated core; 2.
DR Gene3D; 2.120.10.30; TolB, C-terminal domain; 2.
DR InterPro; IPR011042; 6-blade_b-propeller_TolB-like.
DR InterPro; IPR008969; CarboxyPept-like_regulatory.
DR InterPro; IPR000742; EGF-like_dom.
DR InterPro; IPR013111; EGF_extracell.
DR InterPro; IPR022385; Rhs_assc_core.
DR InterPro; IPR031325; RHS_repeat.
DR InterPro; IPR009471; Ten_N.
DR InterPro; IPR028916; Tox-GHH_dom.
DR InterPro; IPR006530; YD.
DR NCBIfam; TIGR03696; Rhs_assc_core; 1.
DR NCBIfam; TIGR01643; YD_repeat_2x; 2.
DR PANTHER; PTHR11219; TENEURIN AND N-ACETYLGLUCOSAMINE-1-PHOSPHODIESTER ALPHA-N-ACETYLGLUCOSAMINIDASE; 1.
DR PANTHER; PTHR11219:SF9; TENEURIN-4; 1.
DR Pfam; PF07974; EGF_2; 1.
DR Pfam; PF05593; RHS_repeat; 2.
DR Pfam; PF06484; Ten_N; 2.
DR Pfam; PF15636; Tox-GHH; 1.
DR SMART; SM00181; EGF; 8.
DR SUPFAM; SSF63829; Calcium-dependent phosphotriesterase; 1.
DR SUPFAM; SSF49464; Carboxypeptidase regulatory domain-like; 1.
DR SUPFAM; SSF57196; EGF/Laminin; 1.
DR SUPFAM; SSF101898; NHL repeat; 1.
DR PROSITE; PS00022; EGF_1; 4.
DR PROSITE; PS01186; EGF_2; 3.
DR PROSITE; PS50026; EGF_3; 2.
DR PROSITE; PS51361; TENEURIN_N; 1.
PE 3: Inferred from homology;
KW Cell adhesion {ECO:0000256|ARBA:ARBA00022889};
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Cell projection {ECO:0000256|ARBA:ARBA00023273};
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157, ECO:0000256|PROSITE-
KW ProRule:PRU00076}; EGF-like domain {ECO:0000256|PROSITE-ProRule:PRU00076};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000291000};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 366..391
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 26..366
FT /note="Teneurin N-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51361"
FT DOMAIN 651..683
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 812..847
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT REGION 1..70
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 155..258
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 14..52
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 53..70
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 160..182
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 214..258
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT DISULFID 673..682
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 816..826
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 837..846
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
SQ SEQUENCE 2785 AA; 309278 MW; E7A7D0EFC176EC66 CRC64;
MEPDHSALSE ARTLFVDVEE RGPEAMDVKE RKPYRSLTRR RDAERRYTSS SADSEEGKAP
QKSYSSSETL KAYDQDARLT YGSRVKDLVP QEAEEFCRAG TNFTLRELGL GEVTPPHGTL
YRTDIGLPHC GYSLGAGSDA ELEADTALSP EHPVRLWGRS TRSGRSSCLS SRANSNLTLT
DTEHENTETD HPSGLQNHSR LRTPPPPLSH AHTPNQHHAA SISSLNRGNF TPRSNPSPAP
TDHSLSGEPP ASGAQEQTHA QDNWLLNSNI PLETRNLGKQ PFLGTLQDSL IEMDILSASR
HDGAYNDGHF LFKPGGTSPL FCSAAPGYPL TSSTVYSPPP RPLPRTTFSR PAFNLKKPSK
YCNWKCAALS AIAISATLVI LLAYFVAMHL FGLNWHLQPM EGQMYEITED TASSWPVPTD
VSLYPSGGTG LEIPDRKGKG AAEGKPSSFF PEDSFIDSGE IDVGRRASQK IPPGTFWRSQ
VFIDHPVHLK FNVSLGKAAL VGIYGRKGLP PSHTQFDFVE LLDGRRLLTQ EARSLEGPQR
QSRGAVPPSS HETGFIQYLD SGIWHLAFYN DGKESEVVSF LTTAIESVDN CPSNCYGNGD
CISGTCHCFL GFLGPDCGRA SCPVLCSGNG QYMKGRCLCH SGWKGAECDV PTSQCIDVAC
SHHGTCIMGT CICNPGYKGE NCEEVDCMDP TCSGRGVCVR GECHCSVGWG GTNCETPRAT
CLDQCSGHGT FLPDTGLCSC DPSWTGHDCS IEICAADCGG HGVCVGGTCR CEDGWMGAAC
DQRACHPRCA EHGTCRDGKC ECSPGWNGEH CTIEGCPGLC NSNGRCTLDL NGWHCVCQLG
WRGAGCDTSM ETACGDSKDN DGDGLVDCMD PDCCLQPLCH VNPLCLGSPD PLDIIQETQA
PVSQQNLHSF YDRIKFLVGR DSTHIIPGEN PFDGGHACVI RGQVMTSDGT PLVGVNISFV
NNPLFGYTIS RQDGSFDLVT NGGVSIILRF ERAPFIAQEH TLWLPWDRFF VMETIVMRHE
ENEIPSCDLS SFARPNPVVS PSPLTSFASS CAEKGPIVPE IQALQEEIAI SGCKMRLSYL
SSRTPGYKSV LRISLTHPTI PFNLMKVHLM VAVEGRLFRK WFAAAPDLSY YFIWDKTDVY
NQKVFGLSEA FVSVGYEYES CPDLILWEKR TAVLQGYEID ASKLGGWSLD KHHALNIQSG
ILHKGNGENQ FVSQQPPVIG SIMGNGRRRS ISCPSCNGLA DGNKLLAPVA LTCGADGSLY
VGDFNYIRRI FPSGNVTNIL ELRNKDFRHS HSPAHKYYLA TDPMSGAVFL SDTTSRRVFK
IKSTVVVKDL VKNSEVVAGT GDQCLPFDDT RCGDGGKATE ATLTNPRGIT VDKSGLIYFV
DGTMIRRIDQ NGVISTLLGS NDLSSARPLS CDSVMDISQV RLEWPTDLAI NPMDNSLYVL
DNNVVLQISE NHQVRIVAGR PMHCQVPGID HFLLSKVAVH ATLESATALA VSHNGVLYIA
ETDEKKINRI RQVTTSGEIS LVAGAPSGCD CKNDVNCDCF SGDDGYAKDA KLNIPSSLAV
CADGELYVAD LGNIRIRFIR KNKPFLNTQN MYELSSPIDQ ELYLFDTSGK HLYTQSLPTG
DYLYNFTYTG DGDVTLITDN NGNVVNVRRD STGMPLWLVV PDGQVYWVTM GTNSALKSVT
TQGHELAMMT YHGNSGLLAT KSNENGWTTF YEYDSFGRLT NVTFPTGQVS SFRSDTDSSV
HVQVETSSKD DVTITTNLSA SGAFYTLLQD QVRNSYFIGA DGSLRLLLAN GMEVALQTEP
HLLAGTVNPT VGKRNVTLPI DNGLNLVEWR QRKEQARGQV TVFGRRLRVH NRNLLSLDFD
RVTRTEKVYD DHRKFTLRIL YDQTGRPSLW SPSSRLNGVN VTYSPGGHIA GVQRGIMSER
MEYDQAGRIT SRIFADGKTW SYTYLEKSMV LLLHSQRQYI FEFDKNDRLS SVTMPNVARQ
TLETIRSVGY YRNIYQPPEG NASVIQDFTE DGHLLHTFYL GTGRRVIYKY GKLSKLAELL
YDTTKVSFTY DETAGMLKTI NLQNEGFTCT IRYRQIGPLI DRQIFRFTEE GMVNARFDYN
YDNSFRVTSM QAVINETPLP IDLYRYDDVS GKTEQFGKFG VIYYDINQII TTTVMTHTKH
FDAYGRMKEV QYEIFRSLMY WMTVQYDNMG RVVKKELKVG PYANTTRYSY EYDADGQLQT
VSINDKPLWR YSYDLNGNLH LLSPGNSARL TPLRYDLRDR ITRLGDVQYK MDEDGFLRQR
GSDVFEYNSA GLLIKAYNRG GGWSVRYRYD GLGRRVSSKS SQSHHLQFFY ADLTNPTKVT
HLYNHSSSEI TSLYYDLQGH LFAMELSSGD EFYIACDNIG TPLAVFSGTG LMIKQILYTA
YGEIYMDTNP NFQIIIGYHG GLYDPLTKLV HMGRRDYDVL AGRWTSPDHE LWKHLSSSNI
MPFNLYMFKN NNPISNSQDI KCFMTDVNSW LLTFGFQLHN VIPGYPKPDM DAMEPSYELV
HTQMKTQEWD NSKSILGVQC EVQKQLKAFV TLERFDQLYG STITSCQQAP ETKKFASSGS
VFGKGVKFAL KDGRVATDII SVANEDGRRV AAVLNNAHYL ENLHFTIDGV DTHYFVKPGP
SEGDLAILGL SGGRRTLENG VNVTVSQINT MLNGRTRRYT DIQLQHGALC LNTRYGTTLD
EEKARVLELA RQRAVRQAWA REQQRLRDGE EGLRAWTEGE KQQVLNTGRV QGYDGFFVIS
VEQYPELSDS ANNIHFMRQS EMGRR
//
