ID A0A452GA34_CAPHI Unreviewed; 1080 AA.
AC A0A452GA34;
DT 08-MAY-2019, integrated into UniProtKB/TrEMBL.
DT 08-MAY-2019, sequence version 1.
DT 27-MAR-2024, entry version 24.
DE RecName: Full=Extracellular calcium-sensing receptor {ECO:0000256|ARBA:ARBA00039746};
GN Name=CASR {ECO:0000313|Ensembl:ENSCHIP00000033388.1};
OS Capra hircus (Goat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC Caprinae; Capra.
OX NCBI_TaxID=9925 {ECO:0000313|Ensembl:ENSCHIP00000033388.1, ECO:0000313|Proteomes:UP000291000};
RN [1] {ECO:0000313|Ensembl:ENSCHIP00000033388.1, ECO:0000313|Proteomes:UP000291000}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Bickhart D.M., Koren S., Rosen B., Hastie A., Liachko I., Sullivan S.T.,
RA Burton J., Sayre B.L., Huson H.J., Lee J., Lam E., Kelley C.M.,
RA Hutchison J.L., Zhou Y., Sun J., Crisa A., Schwartz J.C., Hammond J.A.,
RA Schroeder S.G., Liu G.E., Dunham M., Shendure J., Sonstegard T.S.,
RA Phillippy A.M., Van Tassell C.P., Smith T.P.;
RT "Polished mammalian reference genomes with single-molecule sequencing and
RT chromosome conformation capture applied to the Capra hircus genome.";
RL Submitted (APR-2016) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSCHIP00000033388.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004651};
CC Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 3 family.
CC {ECO:0000256|ARBA:ARBA00007242}.
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DR EMBL; LWLT01000001; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; A0A452GA34; -.
DR Ensembl; ENSCHIT00000041266.1; ENSCHIP00000033388.1; ENSCHIG00000026972.1.
DR GeneTree; ENSGT00940000157596; -.
DR OMA; KCPDDSW; -.
DR Proteomes; UP000291000; Chromosome 1.
DR Bgee; ENSCHIG00000026972; Expressed in metanephros cortex and 6 other cell types or tissues.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0004930; F:G protein-coupled receptor activity; IEA:UniProtKB-KW.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR CDD; cd15282; 7tmC_CaSR; 1.
DR CDD; cd06364; PBP1_CaSR; 1.
DR Gene3D; 3.40.50.2300; -; 2.
DR Gene3D; 2.10.50.30; GPCR, family 3, nine cysteines domain; 1.
DR InterPro; IPR001828; ANF_lig-bd_rcpt.
DR InterPro; IPR000337; GPCR_3.
DR InterPro; IPR011500; GPCR_3_9-Cys_dom.
DR InterPro; IPR038550; GPCR_3_9-Cys_sf.
DR InterPro; IPR017978; GPCR_3_C.
DR InterPro; IPR000068; GPCR_3_Ca_sens_rcpt-rel.
DR InterPro; IPR017979; GPCR_3_CS.
DR InterPro; IPR028082; Peripla_BP_I.
DR PANTHER; PTHR24061; CALCIUM-SENSING RECEPTOR-RELATED; 1.
DR PANTHER; PTHR24061:SF358; EXTRACELLULAR CALCIUM-SENSING RECEPTOR; 1.
DR Pfam; PF00003; 7tm_3; 1.
DR Pfam; PF01094; ANF_receptor; 1.
DR Pfam; PF07562; NCD3G; 1.
DR PRINTS; PR00592; CASENSINGR.
DR PRINTS; PR00248; GPCRMGR.
DR SUPFAM; SSF53822; Periplasmic binding protein-like I; 1.
DR PROSITE; PS00979; G_PROTEIN_RECEP_F3_1; 1.
DR PROSITE; PS00980; G_PROTEIN_RECEP_F3_2; 1.
DR PROSITE; PS00981; G_PROTEIN_RECEP_F3_3; 1.
DR PROSITE; PS50259; G_PROTEIN_RECEP_F3_4; 1.
PE 3: Inferred from homology;
KW Calcium {ECO:0000256|ARBA:ARBA00022837};
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW G-protein coupled receptor {ECO:0000256|ARBA:ARBA00023040};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Receptor {ECO:0000256|ARBA:ARBA00023170};
KW Reference proteome {ECO:0000313|Proteomes:UP000291000};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP};
KW Transducer {ECO:0000256|ARBA:ARBA00023224};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Ubl conjugation {ECO:0000256|ARBA:ARBA00022843}.
FT SIGNAL 1..20
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 21..1080
FT /note="Extracellular calcium-sensing receptor"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5019047669"
FT TRANSMEM 613..638
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 650..671
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 683..707
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 719..744
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 771..793
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 805..827
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 833..855
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 613..877
FT /note="G-protein coupled receptors family 3 profile"
FT /evidence="ECO:0000259|PROSITE:PS50259"
FT REGION 893..964
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 893..940
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 941..959
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1080 AA; 120461 MW; B2D1CA90E659920C CRC64;
MALNSCCWIL LAFSTWCTSA YGPDQRAQKK GDIILGGLFP IHFGVAAKDQ DLKSRPESVE
CIRYNFRGFR WLQAMIFAIE EINSSPALLP NMTLGYRIFD TCNTVSKALE ATLSFVAQNK
IDSLNLDEFC NCSEHIPSTI AVVGATGSGI STAVANLLGL FYIPQVSYAS SSRLLSNKNQ
FKSFLRTIPN DEHQATAMAD IIEYFRWNWV GTIAADDDYG RPGIEKFREE AEERDICIDF
SELISQYSDE EEIQQVVGVI QNSTAKVIVV FSSGPDLEPL IKEIVRRNIT GRIWLASEAW
ASSSLIAMPE YFHVVGGTIG FGLKAGQIPG FREFLQKVHP RKSVHNGFAK EFWEETFNCH
LQEGAKGPLP VDTFLRGHEE GGARISNSST AFRPLCTGEE NISSVETPYM DYTHLRISYN
VYLAVYSIAH ALQDIYTCIP GRGLFTNGSC ADIKKVEAWQ VLKHLRHLNF TSNMGEQVTF
DECGDLAGNY SIINWHLSPE DGSIVFKEVG YYNVYAKKGE RLFINDEKIL WSGFSREVPF
SNCSRDCLAG TRKGIIEGEP TCCFECVECP DGEYSDETDA SACDKCPDDF WSNENHTSCI
AKEIEFLSWT EPFGIALTLF AVLGIFLTAF VLGVFIKFRN TPIVKATNRE LSYLLLFSLL
CCFSSSLFFI GEPQDWTCRL RQPAFGISFV LCISCILVKT NRVLLVFEAK IPTSFHRKWW
GLNLQFLLVF LCTFMQIVIC AIWLNTAPPS SYRNHELEDE IIFITCHEGS LMALGFLIGY
TCLLAAICFF FAFKSRKLPE NFNEAKFITF SMLIFFIVWI SFIPAYASTY GKFVSAVEVI
AILAASFGLL ACIFFNKVYI ILFKPSRNTI EEVRCSTAAH AFKVAARATL RRSNVSRQRS
SSLGGSTGST PSSSISSKSN SEDPFPQQQP ERQKQPQPLA LSPHNPRPPS TPQPQPQSQQ
PPRCKQKVIF GSGTVTFSLS FDEPQKSAVA HRNSTHQTSL EAQKNNDALT KHQALLPLQC
GETDSELTAQ ETGLQGPVSE DHQLEMEDPE EMSPALVVSN SRSFVISGGG STVTENMLRS
//
