ID A0A452GAE5_CAPHI Unreviewed; 1178 AA.
AC A0A452GAE5;
DT 08-MAY-2019, integrated into UniProtKB/TrEMBL.
DT 08-MAY-2019, sequence version 1.
DT 27-MAR-2024, entry version 23.
DE SubName: Full=Integrin subunit alpha 10 {ECO:0000313|Ensembl:ENSCHIP00000033498.1};
GN Name=ITGA10 {ECO:0000313|Ensembl:ENSCHIP00000033498.1};
OS Capra hircus (Goat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC Caprinae; Capra.
OX NCBI_TaxID=9925 {ECO:0000313|Ensembl:ENSCHIP00000033498.1, ECO:0000313|Proteomes:UP000291000};
RN [1] {ECO:0000313|Ensembl:ENSCHIP00000033498.1, ECO:0000313|Proteomes:UP000291000}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Bickhart D.M., Koren S., Rosen B., Hastie A., Liachko I., Sullivan S.T.,
RA Burton J., Sayre B.L., Huson H.J., Lee J., Lam E., Kelley C.M.,
RA Hutchison J.L., Zhou Y., Sun J., Crisa A., Schwartz J.C., Hammond J.A.,
RA Schroeder S.G., Liu G.E., Dunham M., Shendure J., Sonstegard T.S.,
RA Phillippy A.M., Van Tassell C.P., Smith T.P.;
RT "Polished mammalian reference genomes with single-molecule sequencing and
RT chromosome conformation capture applied to the Capra hircus genome.";
RL Submitted (APR-2016) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSCHIP00000033498.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004479,
CC ECO:0000256|RuleBase:RU003762}; Single-pass type I membrane protein
CC {ECO:0000256|ARBA:ARBA00004479, ECO:0000256|RuleBase:RU003762}.
CC -!- SIMILARITY: Belongs to the integrin alpha chain family.
CC {ECO:0000256|ARBA:ARBA00008054, ECO:0000256|RuleBase:RU003762}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|RuleBase:RU003762}.
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DR EMBL; LWLT01000004; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; A0A452GAE5; -.
DR STRING; 9925.ENSCHIP00000033498; -.
DR Ensembl; ENSCHIT00000041377.1; ENSCHIP00000033498.1; ENSCHIG00000027027.1.
DR GeneTree; ENSGT00940000158423; -.
DR Proteomes; UP000291000; Chromosome 3.
DR Bgee; ENSCHIG00000027027; Expressed in ovary and 18 other cell types or tissues.
DR GO; GO:0034680; C:integrin alpha10-beta1 complex; IEA:Ensembl.
DR GO; GO:0098639; F:collagen binding involved in cell-matrix adhesion; IEA:Ensembl.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0007229; P:integrin-mediated signaling pathway; IEA:UniProtKB-KW.
DR CDD; cd01469; vWA_integrins_alpha_subunit; 1.
DR Gene3D; 1.20.5.930; Bicelle-embedded integrin alpha(iib) transmembrane segment; 1.
DR Gene3D; 2.130.10.130; Integrin alpha, N-terminal; 2.
DR Gene3D; 2.60.40.1460; Integrin domains. Chain A, domain 2; 1.
DR Gene3D; 2.60.40.1510; ntegrin, alpha v. Chain A, domain 3; 1.
DR Gene3D; 2.60.40.1530; ntegrin, alpha v. Chain A, domain 4; 1.
DR Gene3D; 3.40.50.410; von Willebrand factor, type A domain; 1.
DR InterPro; IPR013517; FG-GAP.
DR InterPro; IPR013519; Int_alpha_beta-p.
DR InterPro; IPR000413; Integrin_alpha.
DR InterPro; IPR013649; Integrin_alpha_Ig-like_1.
DR InterPro; IPR048285; Integrin_alpha_Ig-like_2.
DR InterPro; IPR028994; Integrin_alpha_N.
DR InterPro; IPR032695; Integrin_dom_sf.
DR InterPro; IPR002035; VWF_A.
DR InterPro; IPR036465; vWFA_dom_sf.
DR PANTHER; PTHR23220; INTEGRIN ALPHA; 1.
DR PANTHER; PTHR23220:SF26; INTEGRIN ALPHA-10; 1.
DR Pfam; PF01839; FG-GAP; 2.
DR Pfam; PF08441; Integrin_A_Ig_1; 1.
DR Pfam; PF20805; Integrin_A_Ig_2; 1.
DR Pfam; PF00092; VWA; 1.
DR PRINTS; PR01185; INTEGRINA.
DR PRINTS; PR00453; VWFADOMAIN.
DR SMART; SM00191; Int_alpha; 5.
DR SMART; SM00327; VWA; 1.
DR SUPFAM; SSF69318; Integrin alpha N-terminal domain; 1.
DR SUPFAM; SSF69179; Integrin domains; 3.
DR SUPFAM; SSF53300; vWA-like; 1.
DR PROSITE; PS51470; FG_GAP; 4.
DR PROSITE; PS50234; VWFA; 1.
PE 3: Inferred from homology;
KW Calcium {ECO:0000256|ARBA:ARBA00022837};
KW Cell adhesion {ECO:0000256|ARBA:ARBA00022889,
KW ECO:0000256|RuleBase:RU003762};
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Integrin {ECO:0000256|ARBA:ARBA00023037, ECO:0000256|RuleBase:RU003762};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU003762};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Receptor {ECO:0000256|ARBA:ARBA00023170, ECO:0000256|RuleBase:RU003762};
KW Reference proteome {ECO:0000313|Proteomes:UP000291000};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|RuleBase:RU003762};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW ECO:0000256|RuleBase:RU003762};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|RuleBase:RU003762}.
FT SIGNAL 1..22
FT /evidence="ECO:0000256|RuleBase:RU003762"
FT CHAIN 23..1178
FT /evidence="ECO:0000256|RuleBase:RU003762"
FT /id="PRO_5018816966"
FT TRANSMEM 992..1011
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU003762"
FT TRANSMEM 1136..1160
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU003762"
FT REPEAT 24..85
FT /note="FG-GAP"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00803"
FT DOMAIN 167..350
FT /note="VWFA"
FT /evidence="ECO:0000259|PROSITE:PS50234"
FT REPEAT 472..534
FT /note="FG-GAP"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00803"
FT REPEAT 535..593
FT /note="FG-GAP"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00803"
FT REPEAT 597..657
FT /note="FG-GAP"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00803"
SQ SEQUENCE 1178 AA; 128899 MW; D980BD17687D453D CRC64;
MEFPLIPHLF LPLTFLTGLC LPFNLDVHRP RLFLGPPEAE FGYSVLQHVG GGRQWILVGA
PWDGPSGDRR GDVYHCLVGG SHSAPCAKGH LGDHPLGNSS RPAVNMHLGM SLLETDGNGG
FMACAPLWSR ACGSSVFSSG ICARVDASFR PQGSLAPTAQ RCPTYMDVVI VLDGSNSIYP
WSEVQTFLRR LVGRLFIDPE QIQVGLVQYG ESSVHEWSLG DFRTKEEVVR AARNLSRREG
RETKTAQAIM MACTEGFSQS HGGRPEAARL LVVVTDGESH DGEELPTALQ ACEAGRVTRY
GIAVLGHYLR RQRDPSSFLR EIRTIASDPD EKFFFNVTDE AALTDIVDAL GDRIFGLEGS
HGENESSFGL EMSQIGFSTH QLKDGILFGM VGAYDWGGSV LWLEEGRRLF PPRTALEDEF
PPALQNHAAY LGYSVSSMFL RGGRRLFLSG APRFSHRGKV IAFQLKKDGA VRVAQSLQGE
QIGSYFGSEL CPLDIDGDGT TDVLLVAAPM FLGPQNKETG RVYVYLVGQP SLLTLQRTLQ
PESPQDARFG FAMGALPDLN QDGFADVAVG APLEDGHRGA LYLYHGAQRG VRPRPAQRIA
AVSMPQALSY FGRSVDGRLD LDGDDLVDVA VGAQGAAILL SSRPIVRLAP SLDVTPPAIS
VVQRDCKRRG QEATCLSAAL CFQVTSRTPG RWDRRFHVRF TASLDEWTTA ARAAFDSSGQ
RLSPRRLRLS VGNITCEQLH FHVLDTSDYL RPVSLTVTFA LDNTTKPGPV LDEGSPTSIR
KLVPFSKDCG PDNECVTDLV LQANMDIRGS RWDGHERPNR DPFVVRGGRR KVLVSATLEN
KKENAYNTSL SLSFSRNLHL SSFTPQSNSP VKVECAAPAP HARLCSVGHP VFQMGAKVTF
LLEFEFSCSF LLSQVLVRLT ATSSSLERNG TLRDNTAQTS AYIQYEPHLL FSSESTLHRY
EVHPYGTLPV GPGPEFKTTL RRSPGKRMGR NLGCYVVSGL IISALLPAVA YGGNYFLSLS
QVITNNASCT VQNLTKPPGP PVHPEELQHT SRLNESNTHC QVVRCHLGRL AKGTEISVGL
LRLVHNEFFR RAKFKSLTVV STFELSTEEG SVLLLTEASR WSESLLEVIQ SRPVLISLWI
LIGSVLGGLL LLALLVFCLW KVSTAKVDSM GHGAHELR
//
