ID A0A452GB82_CAPHI Unreviewed; 656 AA.
AC A0A452GB82;
DT 08-MAY-2019, integrated into UniProtKB/TrEMBL.
DT 08-MAY-2019, sequence version 1.
DT 24-JAN-2024, entry version 16.
DE SubName: Full=Rho GTPase activating protein 18 {ECO:0000313|Ensembl:ENSCHIP00000033696.1};
GN Name=ARHGAP18 {ECO:0000313|Ensembl:ENSCHIP00000033696.1};
OS Capra hircus (Goat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC Caprinae; Capra.
OX NCBI_TaxID=9925 {ECO:0000313|Ensembl:ENSCHIP00000033696.1, ECO:0000313|Proteomes:UP000291000};
RN [1] {ECO:0000313|Ensembl:ENSCHIP00000033696.1, ECO:0000313|Proteomes:UP000291000}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Bickhart D.M., Koren S., Rosen B., Hastie A., Liachko I., Sullivan S.T.,
RA Burton J., Sayre B.L., Huson H.J., Lee J., Lam E., Kelley C.M.,
RA Hutchison J.L., Zhou Y., Sun J., Crisa A., Schwartz J.C., Hammond J.A.,
RA Schroeder S.G., Liu G.E., Dunham M., Shendure J., Sonstegard T.S.,
RA Phillippy A.M., Van Tassell C.P., Smith T.P.;
RT "Polished mammalian reference genomes with single-molecule sequencing and
RT chromosome conformation capture applied to the Capra hircus genome.";
RL Submitted (APR-2016) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSCHIP00000033696.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
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DR EMBL; LWLT01000012; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; A0A452GB82; -.
DR Ensembl; ENSCHIT00000041575.1; ENSCHIP00000033696.1; ENSCHIG00000027143.1.
DR GeneTree; ENSGT00940000157142; -.
DR Proteomes; UP000291000; Chromosome 9.
DR Bgee; ENSCHIG00000027143; Expressed in spleen and 17 other cell types or tissues.
DR GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR CDD; cd04391; RhoGAP_ARHGAP18; 1.
DR Gene3D; 1.10.555.10; Rho GTPase activation protein; 1.
DR InterPro; IPR008936; Rho_GTPase_activation_prot.
DR InterPro; IPR000198; RhoGAP_dom.
DR PANTHER; PTHR14963; RHO GTPASE ACTIVATING PROTEIN 18,19-RELATED; 1.
DR PANTHER; PTHR14963:SF6; RHO GTPASE-ACTIVATING PROTEIN 18; 1.
DR Pfam; PF00620; RhoGAP; 1.
DR SMART; SM00324; RhoGAP; 1.
DR SUPFAM; SSF48350; GTPase activation domain, GAP; 1.
DR PROSITE; PS50238; RHOGAP; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000291000}.
FT DOMAIN 324..516
FT /note="Rho-GAP"
FT /evidence="ECO:0000259|PROSITE:PS50238"
FT REGION 18..67
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 86..105
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 175..217
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 40..67
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 86..101
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 656 AA; 73840 MW; 0E8B06BAE2DC62DA CRC64;
MSWLSNSQAV VLTAYHPSGK DQALGGSHGK GGEEAASSRR YGQYTMNQEV TKVTERPPFG
RSSSQDSLDE LSMEAYWTEL ENIKKSHENR QDDQEVVVVK EPDEGELEEE WLKEAGLSNL
FGETAGDPQE SMVFLSTLTR TQAAAVQKRV ETVSQTLRKK NKQYQVPDVR DIFAQQTGSK
EKEAPDGTES QSVGTDENKY QGKDDQASHL GVGGKELTPL VPEEAPASET DINLEVSFAE
QAVSQKESSR EKIQRSKGDD AALLTYRVRK DKTGTTRIGD LAPQDMKKVC HLALIELTAL
YDVLGIELKQ QKAVKIKTKV FIYVCMKEIM PKSECPSVYA QLISRIEEGG LETEGLLRIP
GAAVRIKNLC QELEAKFYEG TFNWESVKQH DAASLLKLFI RELPQPLLSV EYLKAFQAVQ
NLPTRKQQLQ ALNLLVILLP EANRDTLKAL LEFLQRVVDN KEKNKMTVMN VAMVMAPNLF
MYHSLGLKAG EQREFVMAAG IANIMHLLIK YQKFLWTIPK FIVNQVRKQN TENHRKDKKA
MKKLLKKMAY DREKYEKQDK SANDADVPQG VIRVQAPHLS KVSMAIQLTE ELKASDVLAR
FLSQESGVAQ TLKNGEVFLY EIGGNIGERC LDDDTYMKDL YQLNPNAEWV IKSKPS
//
