ID   A0A452GL95_9SAUR        Unreviewed;       759 AA.
AC   A0A452GL95;
DT   08-MAY-2019, integrated into UniProtKB/TrEMBL.
DT   08-MAY-2019, sequence version 1.
DT   24-JAN-2024, entry version 19.
DE   RecName: Full=SH3 domain-containing protein {ECO:0000259|PROSITE:PS50002};
OS   Gopherus agassizii (Agassiz's desert tortoise).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Archelosauria; Testudinata; Testudines; Cryptodira; Durocryptodira;
OC   Testudinoidea; Testudinidae; Gopherus.
OX   NCBI_TaxID=38772 {ECO:0000313|Ensembl:ENSGAGP00000002380.1, ECO:0000313|Proteomes:UP000291020};
RN   [1] {ECO:0000313|Proteomes:UP000291020}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=28562605;
RA   Tollis M., DeNardo D.F., Cornelius J.A., Dolby G.A., Edwards T.,
RA   Henen B.T., Karl A.E., Murphy R.W., Kusumi K.;
RT   "The Agassiz's desert tortoise genome provides a resource for the
RT   conservation of a threatened species.";
RL   PLoS ONE 12:e0177708-e0177708(2017).
RN   [2] {ECO:0000313|Ensembl:ENSGAGP00000002380.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2023) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Cell junction, focal adhesion
CC       {ECO:0000256|ARBA:ARBA00004246}.
CC   -!- SIMILARITY: Belongs to the CAS family. {ECO:0000256|ARBA:ARBA00007848}.
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DR   AlphaFoldDB; A0A452GL95; -.
DR   Ensembl; ENSGAGT00000002729.1; ENSGAGP00000002380.1; ENSGAGG00000001321.1.
DR   Proteomes; UP000291020; Unassembled WGS sequence.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR   GO; GO:0005925; C:focal adhesion; IEA:UniProtKB-SubCell.
DR   GO; GO:0007155; P:cell adhesion; IEA:UniProtKB-KW.
DR   CDD; cd12000; SH3_CASS4; 1.
DR   Gene3D; 1.20.120.230; Alpha-catenin/vinculin-like; 1.
DR   Gene3D; 1.20.120.830; Serine-rich domain; 1.
DR   Gene3D; 2.30.30.40; SH3 Domains; 1.
DR   InterPro; IPR021901; CAS_C.
DR   InterPro; IPR037362; CAS_fam.
DR   InterPro; IPR035744; CASS4_SH3.
DR   InterPro; IPR014928; Serine_rich_dom.
DR   InterPro; IPR038319; Serine_rich_sf.
DR   InterPro; IPR036028; SH3-like_dom_sf.
DR   InterPro; IPR001452; SH3_domain.
DR   PANTHER; PTHR10654; CAS SCAFFOLDING PROTEIN; 1.
DR   PANTHER; PTHR10654:SF19; CAS SCAFFOLDING PROTEIN FAMILY MEMBER 4; 1.
DR   Pfam; PF12026; CAS_C; 1.
DR   Pfam; PF08824; Serine_rich; 1.
DR   Pfam; PF14604; SH3_9; 1.
DR   PRINTS; PR00452; SH3DOMAIN.
DR   SMART; SM00326; SH3; 1.
DR   SUPFAM; SSF50044; SH3-domain; 1.
DR   PROSITE; PS50002; SH3; 1.
PE   3: Inferred from homology;
KW   Cell adhesion {ECO:0000256|ARBA:ARBA00022889};
KW   Cell junction {ECO:0000256|ARBA:ARBA00022949};
KW   Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW   Reference proteome {ECO:0000313|Proteomes:UP000291020};
KW   SH3 domain {ECO:0000256|ARBA:ARBA00022443, ECO:0000256|PROSITE-
KW   ProRule:PRU00192}.
FT   DOMAIN          2..64
FT                   /note="SH3"
FT                   /evidence="ECO:0000259|PROSITE:PS50002"
FT   REGION          244..268
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          332..360
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          374..394
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        244..266
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   759 AA;  85503 MW;  BBFE29F697614E55 CRC64;
     MEGNTLAKAL YDNKAECSDE LAFRKGDILT VLEQNVLESE GWWKCSLHGR QGLAPANRLQ
     LLAGSQAGML PPSSEHDSQE LHICQQNIYQ VPSAPKSSTL SPTYERMDSW IKPVRSPVSS
     PPTQEIYQVP ALAAQLFNSA IVLSDCTLLL HLELPPHHPC KTAKYYLVYD VPPTTARDHD
     ISLQNLPQIK CLGHYNTLPN PRKSEWIYDI PVSPEKMGLK KDPSDSSLEK QVLYDIPPAR
     YGTSLQNVPP TNIKSKSMNP QMYDVPPTQR KLTFPDISRY NVPSSRDMLL LQQNGNYHVP
     PSFLTPRVEQ QNSEPNVYDI PKVLPTALQH RKGTEKNKSS FGNHTYNIPP QLSKDAKLEQ
     DRLSVSSVDS RINTLSTSSS TSAESSFTSS SEEPAKEINL ELDLAIETLT KLQHSVSSSV
     ASLMIFVSSR WRFQEHLETN LEEIHRAIDH IKVSLGEFLD FAQVIKVNAS CVTDNNLQTR
     IKTQLKILKD SFQILVETRE ALNNCKWSLE VLVIKKPQNN PDDLDRFVMV ARAIPDDIKR
     FVSIIIANGK LLFKKNSKEQ EIKSPKIGTD HKMAKPIPIP RRRELDSLQR NTLDKPNKNK
     VYSEKSRENV TEDCDYVQLQ VSVLPPSKKH NIQSNLVLAK KITLSENCRL YFGALHKAIS
     VFTSSLSNNQ PPEIFIAQSK LIIMVGQKLV DSLCQETQEK DIRNDILCSS SHFCSLLKNL
     AVATKNAAVQ YANAGAMQEL QNQAKELSKY TQQFRAMME
//