ID A0A452GLG1_9SAUR Unreviewed; 835 AA.
AC A0A452GLG1;
DT 08-MAY-2019, integrated into UniProtKB/TrEMBL.
DT 08-MAY-2019, sequence version 1.
DT 24-JAN-2024, entry version 20.
DE SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSGAGP00000002456.1};
OS Gopherus agassizii (Agassiz's desert tortoise).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Testudinata; Testudines; Cryptodira; Durocryptodira;
OC Testudinoidea; Testudinidae; Gopherus.
OX NCBI_TaxID=38772 {ECO:0000313|Ensembl:ENSGAGP00000002456.1, ECO:0000313|Proteomes:UP000291020};
RN [1] {ECO:0000313|Proteomes:UP000291020}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=28562605;
RA Tollis M., DeNardo D.F., Cornelius J.A., Dolby G.A., Edwards T.,
RA Henen B.T., Karl A.E., Murphy R.W., Kusumi K.;
RT "The Agassiz's desert tortoise genome provides a resource for the
RT conservation of a threatened species.";
RL PLoS ONE 12:e0177708-e0177708(2017).
RN [2] {ECO:0000313|Ensembl:ENSGAGP00000002456.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
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DR STRING; 38772.ENSGAGP00000002456; -.
DR Ensembl; ENSGAGT00000002814.1; ENSGAGP00000002456.1; ENSGAGG00000001992.1.
DR Ensembl; ENSGAGT00000002824.1; ENSGAGP00000002466.1; ENSGAGG00000001992.1.
DR Proteomes; UP000291020; Unassembled WGS sequence.
DR GO; GO:0005096; F:GTPase activator activity; IEA:UniProtKB-KW.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0035556; P:intracellular signal transduction; IEA:InterPro.
DR GO; GO:0046580; P:negative regulation of Ras protein signal transduction; IEA:InterPro.
DR CDD; cd08401; C2A_RasA2_RasA3; 1.
DR CDD; cd04010; C2B_RasA3; 1.
DR CDD; cd13371; PH_GAP1_mammal-like; 1.
DR CDD; cd05134; RasGAP_RASA3; 1.
DR Gene3D; 2.60.40.150; C2 domain; 2.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR InterPro; IPR000008; C2_dom.
DR InterPro; IPR035892; C2_domain_sf.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR001849; PH_domain.
DR InterPro; IPR039360; Ras_GTPase.
DR InterPro; IPR037774; RASA3_PH.
DR InterPro; IPR023152; RasGAP_CS.
DR InterPro; IPR001936; RasGAP_dom.
DR InterPro; IPR008936; Rho_GTPase_activation_prot.
DR InterPro; IPR001562; Znf_Btk_motif.
DR PANTHER; PTHR10194:SF53; RAS GTPASE-ACTIVATING PROTEIN 3; 1.
DR PANTHER; PTHR10194; RAS GTPASE-ACTIVATING PROTEINS; 1.
DR Pfam; PF00779; BTK; 1.
DR Pfam; PF00168; C2; 2.
DR Pfam; PF00169; PH; 1.
DR Pfam; PF00616; RasGAP; 2.
DR SMART; SM00107; BTK; 1.
DR SMART; SM00239; C2; 2.
DR SMART; SM00233; PH; 1.
DR SMART; SM00323; RasGAP; 1.
DR SUPFAM; SSF49562; C2 domain (Calcium/lipid-binding domain, CaLB); 2.
DR SUPFAM; SSF48350; GTPase activation domain, GAP; 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR PROSITE; PS50004; C2; 2.
DR PROSITE; PS50003; PH_DOMAIN; 1.
DR PROSITE; PS00509; RAS_GTPASE_ACTIV_1; 1.
DR PROSITE; PS50018; RAS_GTPASE_ACTIV_2; 1.
DR PROSITE; PS51113; ZF_BTK; 1.
PE 4: Predicted;
KW GTPase activation {ECO:0000256|ARBA:ARBA00022468};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Reference proteome {ECO:0000313|Proteomes:UP000291020};
KW Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|PROSITE-
KW ProRule:PRU00432}.
FT DOMAIN 1..112
FT /note="C2"
FT /evidence="ECO:0000259|PROSITE:PS50004"
FT DOMAIN 123..264
FT /note="C2"
FT /evidence="ECO:0000259|PROSITE:PS50004"
FT DOMAIN 331..525
FT /note="Ras-GAP"
FT /evidence="ECO:0000259|PROSITE:PS50018"
FT DOMAIN 577..678
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
SQ SEQUENCE 835 AA; 96147 MW; 721458414BAA4D97 CRC64;
MAVEEEGLRV FQSVRIKIGE AKNLPTYPGP NKMRDCYCTV NLDQEEVFRT KIVEKSLCPF
YGEDFYCEIP RSFRHLSFYI FDRDVFRRDS IIGKVAIQKE DLQKYHNRDT WFQLQHVDAD
SEVQGKVHLE LRLSEVITDT GVICHKLATR VLECKGLPIV NGQCDPYATV TLAGPYRSEA
KKTKVKKKTN NPQFDEVFYF EVTRPCSYNK KSHFDIEDAD EVDKMEIRVD LWNASNLKFG
DEFLGELRLP LKCLRQSSSY EAWYFLQPRD NGNKSLKPDD LGSLRLNVVY TEDHVFSSDY
YSPLRDLLLK SADVEPVSAS AAHVLGEVCR EKQEAAIPLV RLFLHYGKIV PFISAIANAE
VKRTQDPNTI FRGNSLTSKC IDETMKLAGM HYLQVTLKPI LDEICQLHKP CEIDPVKLKD
GENLENNREN LRQYVDRIFT VITKSGVTCP TVMCDIFFSL RESAAKRFQG DPDVRYTAVS
SFIFLRFFAP AILSPNLFQL TPHHPDPQTS RTLTLISKTI QTLGSLSKSK SASFKESYMA
TFYDYFNEQK YADAVKNFLD LISSSGRRDH KSIEQPILLK EGFMIKRAQG RKRFGMKNFK
KRWFRLTNHE FTYQKSKGDH PLCSIPIENI LAVEKLEEES FKMKNMFQVI QPERVLYIQA
NNCVEAKDWI DILTKVSQCN KKRLTVYHPS AYLNGHWLCC KATADNTPGC TPCTGGLPAN
IQLDIDGDRE TERIYSLFNL YMPKLEKMQE ACGSKSVYDG PEQEEYSTFI IDDPKETYKT
LKQIIDGVGT LEQEHAQYKR DKFKKTKYGS QEHPIGDKSF QSYIRQQSEI SAHSI
//
