ID A0A452GPI0_9SAUR Unreviewed; 1170 AA.
AC A0A452GPI0;
DT 08-MAY-2019, integrated into UniProtKB/TrEMBL.
DT 08-MAY-2019, sequence version 1.
DT 24-JAN-2024, entry version 19.
DE RecName: Full=G-protein coupled receptors family 2 profile 2 domain-containing protein {ECO:0000259|PROSITE:PS50261};
OS Gopherus agassizii (Agassiz's desert tortoise).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Testudinata; Testudines; Cryptodira; Durocryptodira;
OC Testudinoidea; Testudinidae; Gopherus.
OX NCBI_TaxID=38772 {ECO:0000313|Ensembl:ENSGAGP00000003681.1, ECO:0000313|Proteomes:UP000291020};
RN [1] {ECO:0000313|Proteomes:UP000291020}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=28562605;
RA Tollis M., DeNardo D.F., Cornelius J.A., Dolby G.A., Edwards T.,
RA Henen B.T., Karl A.E., Murphy R.W., Kusumi K.;
RT "The Agassiz's desert tortoise genome provides a resource for the
RT conservation of a threatened species.";
RL PLoS ONE 12:e0177708-e0177708(2017).
RN [2] {ECO:0000313|Ensembl:ENSGAGP00000003681.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
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DR AlphaFoldDB; A0A452GPI0; -.
DR Ensembl; ENSGAGT00000004257.1; ENSGAGP00000003681.1; ENSGAGG00000002973.1.
DR Proteomes; UP000291020; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0004930; F:G protein-coupled receptor activity; IEA:InterPro.
DR GO; GO:0007166; P:cell surface receptor signaling pathway; IEA:InterPro.
DR CDD; cd15444; 7tmB2_GPR64; 1.
DR Gene3D; 2.60.220.50; -; 1.
DR Gene3D; 1.20.1070.10; Rhodopsin 7-helix transmembrane proteins; 1.
DR InterPro; IPR046338; GAIN_dom_sf.
DR InterPro; IPR017981; GPCR_2-like_7TM.
DR InterPro; IPR000832; GPCR_2_secretin-like.
DR InterPro; IPR017983; GPCR_2_secretin-like_CS.
DR InterPro; IPR000203; GPS.
DR PANTHER; PTHR12011; ADHESION G-PROTEIN COUPLED RECEPTOR; 1.
DR PANTHER; PTHR12011:SF264; ADHESION G-PROTEIN COUPLED RECEPTOR G2; 1.
DR Pfam; PF00002; 7tm_2; 1.
DR Pfam; PF01825; GPS; 1.
DR PRINTS; PR00249; GPCRSECRETIN.
DR SMART; SM00303; GPS; 1.
DR SUPFAM; SSF81321; Family A G protein-coupled receptor-like; 1.
DR PROSITE; PS00650; G_PROTEIN_RECEP_F2_2; 1.
DR PROSITE; PS50261; G_PROTEIN_RECEP_F2_4; 1.
DR PROSITE; PS50221; GPS; 1.
PE 4: Predicted;
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000291020};
KW Signal {ECO:0000256|ARBA:ARBA00022729};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 779..806
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 818..841
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 853..876
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 888..909
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 937..966
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 987..1006
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1012..1035
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 781..1036
FT /note="G-protein coupled receptors family 2 profile 2"
FT /evidence="ECO:0000259|PROSITE:PS50261"
FT REGION 43..63
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 347..369
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 476..513
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1071..1090
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1170 AA; 128074 MW; 2478378990626319 CRC64;
MIACGVQHCC AGRIQELLLK FKISLAIILL HVFLATSDIP NDVTSRSSVA KSSETISDTT
SLEKTSTSES SIVTFIAYPI NASATSSDTG TAARTLSVLP KPNHTETTNI PEFNFSTTVD
TTSLERTSAE DRTLSVWPEP NQTETSNIPE FNFSTTAEKL SANRTFNVTD SVTLPTTANI
NGISHCKNET KLSGNNLYNL SAICNNSVFY LGYVKFQYSE KSNNTSVSVE IIDDVTSSNK
VTKLIPFTTP TLQESKISEF NKTLQEESES SFMECAAENQ SISVCKFIVK LAKTVNISSL
LARLKRAEVV QIELCFCSAL QSWPSTAEEL QILQCYGQDT VVCAAPSKSG PPASPAASSS
NISIDKPPPD IHAPKQTTVF FPHLSTKSST TNHLLTKLIA MHSTTPTAIP PATPSPINTT
TIPSATSSPT TTITIPSTVP FTKYFTTSLT KSTTISLPMS PTKPATVVPS TIPSTKPINV
SPAPSTEPTI LSPPGIQSTT DSQATGTNGK TGNILDNSSN ITYTTINPSE VDSIISKMES
ALSAQKIEPK VAREMVDTIS NLLNVPLLSP VSKRIIKIVD AIGLKLNFST ESINFTSPAL
ALAVTKVHSS NFSKMSFAVQ DSSDLQISLG TQAPINSVGA IALPSSLLTN LSSEDMALAS
RIIFNFFEKT TPFQDSSLEN LSLISNVISS SVANLTLIDL KANVTVTLQN TRPIQDNLTV
RCAFWDFNEN GGKGGWSYEG CMVKERRANE TVCTCNHLTS FGVLLDLSRN PTLPPIQTLV
LTFITYIGCG FSAIFLSVTL VTYVAFEKIR RDYPSKILIQ LCAALLLLNL VFLLDSWIAL
YDIRGLCITV AVFLHYFLLV SFTWMGLEAF HMYLALVKVF NTYVRKYILK FCIIGWGVPL
LVVGIVLAIT PNNYGLGSYG KFPNGSPDEF CWINNNIVFY ITVVGYFCMI FLLNVSMFIV
VLIQLCRIKK KKQLGTQRKT SIQDLRSVAG LTFLLGITWG FAFFAWGPVN LIFMYLFAIF
NTLQGFFIFI FYCVAKENVR KQWRRYLCCG KFRLAENSDW SRTATNGLKK QTVNQGVSSS
SNSLQSNSNS TNSTTLLMNN DYSVHANGNG NVSSEKNGVS FNVQNGDVCL QDFSGKQLVF
HEKDDADHKK TRVSLRRTSK RGSLHFIKQM
//
