ID A0A452GQ81_9SAUR Unreviewed; 3721 AA.
AC A0A452GQ81;
DT 08-MAY-2019, integrated into UniProtKB/TrEMBL.
DT 08-MAY-2019, sequence version 1.
DT 27-MAR-2024, entry version 25.
DE SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSGAGP00000003977.1};
OS Gopherus agassizii (Agassiz's desert tortoise).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Testudinata; Testudines; Cryptodira; Durocryptodira;
OC Testudinoidea; Testudinidae; Gopherus.
OX NCBI_TaxID=38772 {ECO:0000313|Ensembl:ENSGAGP00000003977.1, ECO:0000313|Proteomes:UP000291020};
RN [1] {ECO:0000313|Proteomes:UP000291020}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=28562605;
RA Tollis M., DeNardo D.F., Cornelius J.A., Dolby G.A., Edwards T.,
RA Henen B.T., Karl A.E., Murphy R.W., Kusumi K.;
RT "The Agassiz's desert tortoise genome provides a resource for the
RT conservation of a threatened species.";
RL PLoS ONE 12:e0177708-e0177708(2017).
RN [2] {ECO:0000313|Ensembl:ENSGAGP00000003977.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Secreted, extracellular space, extracellular
CC matrix, basement membrane {ECO:0000256|ARBA:ARBA00004302}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00076}.
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DR Ensembl; ENSGAGT00000004631.1; ENSGAGP00000003977.1; ENSGAGG00000002525.1.
DR Proteomes; UP000291020; Unassembled WGS sequence.
DR GO; GO:0005604; C:basement membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProt.
DR GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR GO; GO:0030154; P:cell differentiation; IEA:UniProt.
DR GO; GO:0072359; P:circulatory system development; IEA:UniProt.
DR CDD; cd00054; EGF_CA; 3.
DR CDD; cd00055; EGF_Lam; 8.
DR CDD; cd00096; Ig; 4.
DR CDD; cd05754; IgI_Perlecan_like; 1.
DR CDD; cd00110; LamG; 3.
DR Gene3D; 2.60.120.200; -; 3.
DR Gene3D; 2.60.40.10; Immunoglobulins; 19.
DR Gene3D; 2.10.25.10; Laminin; 11.
DR InterPro; IPR013320; ConA-like_dom_sf.
DR InterPro; IPR001881; EGF-like_Ca-bd_dom.
DR InterPro; IPR000742; EGF-like_dom.
DR InterPro; IPR007110; Ig-like_dom.
DR InterPro; IPR036179; Ig-like_dom_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR013098; Ig_I-set.
DR InterPro; IPR003599; Ig_sub.
DR InterPro; IPR003598; Ig_sub2.
DR InterPro; IPR013106; Ig_V-set.
DR InterPro; IPR001791; Laminin_G.
DR InterPro; IPR000034; Laminin_IV.
DR InterPro; IPR002049; LE_dom.
DR PANTHER; PTHR44170:SF48; MYOPALLADIN; 1.
DR PANTHER; PTHR44170; PROTEIN SIDEKICK; 1.
DR Pfam; PF00008; EGF; 2.
DR Pfam; PF07679; I-set; 6.
DR Pfam; PF13927; Ig_3; 13.
DR Pfam; PF00052; Laminin_B; 3.
DR Pfam; PF00053; Laminin_EGF; 9.
DR Pfam; PF00054; Laminin_G_1; 3.
DR SMART; SM00181; EGF; 10.
DR SMART; SM00179; EGF_CA; 3.
DR SMART; SM00180; EGF_Lam; 8.
DR SMART; SM00409; IG; 19.
DR SMART; SM00408; IGc2; 19.
DR SMART; SM00406; IGv; 6.
DR SMART; SM00281; LamB; 3.
DR SMART; SM00282; LamG; 3.
DR SUPFAM; SSF49899; Concanavalin A-like lectins/glucanases; 3.
DR SUPFAM; SSF57196; EGF/Laminin; 7.
DR SUPFAM; SSF48726; Immunoglobulin; 19.
DR PROSITE; PS00022; EGF_1; 4.
DR PROSITE; PS01186; EGF_2; 2.
DR PROSITE; PS50026; EGF_3; 4.
DR PROSITE; PS01248; EGF_LAM_1; 7.
DR PROSITE; PS50027; EGF_LAM_2; 5.
DR PROSITE; PS50835; IG_LIKE; 19.
DR PROSITE; PS50025; LAM_G_DOMAIN; 3.
DR PROSITE; PS51115; LAMININ_IVA; 3.
PE 4: Predicted;
KW Basement membrane {ECO:0000256|ARBA:ARBA00022869};
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157, ECO:0000256|PROSITE-
KW ProRule:PRU00076};
KW EGF-like domain {ECO:0000256|ARBA:ARBA00022536, ECO:0000256|PROSITE-
KW ProRule:PRU00076}; Extracellular matrix {ECO:0000256|ARBA:ARBA00022869};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Laminin EGF-like domain {ECO:0000256|ARBA:ARBA00023292,
KW ECO:0000256|PROSITE-ProRule:PRU00460};
KW Reference proteome {ECO:0000313|Proteomes:UP000291020};
KW Secreted {ECO:0000256|ARBA:ARBA00022525}.
FT DOMAIN 59..244
FT /note="Laminin IV type A"
FT /evidence="ECO:0000259|PROSITE:PS51115"
FT DOMAIN 278..327
FT /note="Laminin EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50027"
FT DOMAIN 462..639
FT /note="Laminin IV type A"
FT /evidence="ECO:0000259|PROSITE:PS51115"
FT DOMAIN 673..722
FT /note="Laminin EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50027"
FT DOMAIN 784..833
FT /note="Laminin EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50027"
FT DOMAIN 860..1066
FT /note="Laminin IV type A"
FT /evidence="ECO:0000259|PROSITE:PS51115"
FT DOMAIN 1100..1149
FT /note="Laminin EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50027"
FT DOMAIN 1150..1207
FT /note="Laminin EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50027"
FT DOMAIN 1212..1300
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 1306..1394
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 1421..1504
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 1511..1596
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 1605..1687
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 1698..1780
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 1795..1877
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 1891..1967
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 1984..2066
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 2081..2163
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 2178..2260
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 2275..2357
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 2371..2459
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 2462..2550
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 2561..2640
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 2647..2729
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 2739..2821
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 2826..2910
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 2915..2991
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 3003..3179
FT /note="Laminin G"
FT /evidence="ECO:0000259|PROSITE:PS50025"
FT DOMAIN 3175..3212
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 3215..3253
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 3259..3439
FT /note="Laminin G"
FT /evidence="ECO:0000259|PROSITE:PS50025"
FT DOMAIN 3435..3472
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 3474..3507
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 3532..3719
FT /note="Laminin G"
FT /evidence="ECO:0000259|PROSITE:PS50025"
FT REGION 1245..1265
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 3355..3377
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT DISULFID 297..306
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00460"
FT DISULFID 692..701
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00460"
FT DISULFID 784..796
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00460"
FT DISULFID 804..813
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00460"
FT DISULFID 1119..1128
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00460"
FT DISULFID 1178..1187
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00460"
FT DISULFID 3202..3211
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 3224..3241
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 3243..3252
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 3462..3471
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 3497..3506
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
SQ SEQUENCE 3721 AA; 399548 MW; E6C02150B55004D6 CRC64;
MVFGIPDGVL SLTPRRGPCP EGYFHVEGTS KCLPCFCFGI TTACHGTSRY RDQIRLRFDT
PDDFKGVNVT TPAQPGTLPL SSTQLQIDPA LQEFQLVDLS RRFLTHDSFW TLPSQFLGNK
VDSYGGYLSF KVRYGLARGQ SEPVQKSNVV IVGNGQKLIY RVQVPTQPSV VNQRQIHFTE
ENWQQESGAP VSREMLLLAL QNLESILVQT VYDNKMASVG LSDIAMDTTT MELTSQGVAQ
GVEECRCPIG YSGLSCERCD ARFERVREGP YLGTCSGCNC HGHSSSCDRV YGYCLNCQHN
TEGPQCNKCK PGFFGDATRG NATACRPCPC PYTDPARRFS DTCFLDTDGQ ATCDACAQGY
TGRRCESCAR GYEGNPMQPG GSCVRTSQEI IQCDERGSSD STGGACRCKP NVAGRLCNEC
TSGAFHLSEQ NPDGCLKCFC MGVSQQCASS YWNREQVRAL DGERAHFSLA NLANTRTVSE
GIRSPGHAEL AFSAFNTLPR DVYYWVLPDR FKGDKVTSYG GELHYTITHS AAPGAQPLPG
QPDVRLRGNG IFLEHFAEAG PLPRTPTRFT VPFRERAWRR ADGQDATREH LLMALADIDL
FMIRASYMDR PAESRLSNIH MDVAVPHATG LERAVEVEEC TCPPGYRGPS CQDCDVGYAR
TSSGLYLGTC ERCDCSGHSG ECDAETGDCQ NCQDNTEGTR CERCQPGYYG DARQGTPTDC
QPCPCHGPYA TSQATKTCFL DMDGQPTCDA CTAGYVGRQC QRCAAGYVGN PSLGQPCREL
NRNCSCDPQG SVSRQCDARG QCQCKPHVEG PSCSSCRANH FHLSTENREG CLPCFCMGVT
QQCTSSSYYR GLVTSPFLPG DFQNFALVNR QHSTRIVTGF AVELSAEGPQ LSFGRFGQLG
QESYYWQLPE PYQGDKYSLV YKGFSLLPES VFYWQLPGAF LGDKVGSYGG RLRYTLSYSS
GGRSAPLPDA DVQITGNDIT LVAYQPELLP RDWRSFEIIF QEQYWKRPDG QHATREHLMM
ALADLDEILI RATYSTDMVS ASIAGISMET AMPTYSSLPL ALEVEECHCP PGYQGLSCQD
CAAGYTRTGG GLYLGHCELC ECNGHSDSCH PETGACSNCL HNAAGEFCEQ CAHGYYGDAT
TGTPEDCQPC ACPLSEPENQ FSRTCESLGG GGYRCSACEP GYTGQYCEQC APGYVGNPSV
RGQKCVPVDR APFMVRVHPP KTTVSQGGEV TLRCQASGSP PYYYSWSRED GRPVPSTAQS
RRQGEELHFP SIQPSEAGVY VCTCRSLQHS NSSRAEVIVT EAPSKPITVT VEEKRVQSVK
PGADVTFICT AKSKSPAYTL VWTRQNHGKL PRRAMDFNGI LTIRNVQPED AGVYVCTGSN
MLDMAEGMAT LHVQAPPKTQ MFYGPIEVME GHRPSATAVL PTATIEPAQL TVQPGQPAEF
HCIASGSPPP TVEWIGGQAG VMSRKAVIQG GTLRFPAVEP SDEAEYLCRV RSSAGQHVAR
AFLQVHSASV PQVQVSPERT EVQEGSTVRL YCRAAGSPTA TITWEKQGGS LPPQSRSERT
DIATLVIPSI TAADSGVYLC IGTSPAGVGS ARIEVVVLRA SGVVPPIRIE ALSSSIAEGQ
TLDLKCLVTG QAPATVTWYK RGGSLPARHQ VSGSHLRISQ VSAADSGEYV CRVSIGANSR
EASIPVTVQH SASSPHAPPI HIESSSSAVT EGQSLDLKCL VTGQSPATVM WYKRGGSLPE
GHQVSGSHLR LVRVSVADSG EYVCRVSTSA GIQETSIIVT IYRATGSPYS SGIEPPVRIE
SSSSSISEGQ TLDLQCLVTG QAPATITWYK RGGSLPASHQ VSGSYLRIPQ VLAADAGEYV
CRVSTGTMVQ EASVIVTISS TGSSYSSGMR PPIWIEQSSS SVTEGQTLDL KCLVTGQAPA
TVTWYKRGGS LPADHQLSGS HLRLVQVSAA DSGEYVCRAG TKEASVLVTI QQSSRISYPS
GVTPPVRIES SSSSVAEGQT LDLNCLVAGQ VQPRVTWHKR GGSLPASHQV SGSRLRIPQV
SAADSGEYIC RVSTGAITQE TSLIVTIQGG AGSSYSLGVT PLVRIETSSA SIAEGQTLDL
NCMVAGQAQP RITWYRREGS LPASSQVSGS RLRIPQVSAA DSGEYICHVN NGAGPLEASV
IVTIPHSAGF LYPSGMAPPV RIESSSSSIA EGQTLDLNCL VAGQAQPRVT WYKRGGSLPA
SHQVSGSRLR IPQVSAADSG EYVCRVSTGA VTQEAALVIT IEDSTSPSYS SGMAPPIRIE
SSSSSITEGQ TLELQCLVAG QAPAIVTWYK RGGSLPASHQ VSGSRLRLVQ VSAADSGEYV
CRVSTSAGPR EASITVSVPS GTSSSYRLQS PIISIEPHST AVRQGEDATF KCRIHGGARP
INITWKMAPK QHLQDNVKIS PNGSVITISR ARPSNQGAYR CVASNRYGVA NSVVNLMVQG
SPTVSVMPKG PVTVKAGKSI SLDCLGMGDP RPLVRWSRLG TRQKLEHQKL LPLESQAVLQ
ILAAKPEDAG TYICMAQNSI GSAQVQVEVS VEAANGKPGA PEITVKPTLT VVAGETATLQ
CSATGDPPPS IQWSKLRAPL PWQHRVVNNT LLIPRVAQQD SGQYICNASN AAGFTEAFVT
LDVETPPYAT ILPEEVSVAA GEAVRLQCLA HGTPPLRYQW SKTNGSLSSN AVLRESALHI
SPTAPEDSGT YRCLVSNRVG SAETFAQVSV QGSAPSASPT VRVTPQTVVK GVGGMAEFTC
SVTGDARARI EWFREGGELP TSHSVRNGVL RIQNLDRGCQ GVYTCRVSSP SGQAQDSARL
VIQALPKVMI NMRTSVQSVL VGAAVEFECL AIGDPKAHIT WSKVGSRIRP EVVISGGMVK
IERVEQSDAG QYRCTATNDV GTVQSNVILH VQSIPQIAAQ PEIREVTTGS RAVFPCLASG
FPVPEIKWTK LEGDLPKDIC LENNVLTIPS VKPEDAGIYV CTASNRQGKV TAFSMLKVRE
RVVPYFTQNP RTFLALPTIK DAYKKFEIQI TFRPDTADGM LLYNGQKKST GADFVSFGLV
GGCPEFRFDA GSGMATIRHP APIRLGEFHT VWLYRNLTQG SLVLDSHPPV NGTSQGKFQG
LDLNEELYLG GYPDYIAIAK SGLSSGFVGC VRQLLVQGEE VIFKDLDLKA HGVSNCPTCR
DRPCQNGGVC RDSESSSYVC HCPQEFTGSN CEHSQALHCH PEACGPDATC INRADGQGYR
CRCHLGKSGE TCMEGIMATT PSFNGSDSFI SYPPLTNIHY ELRLDTEFKP LSPDGLIMFS
GGTGAPVEDF VSLSMASGHV EFRYELGSGM AVLRSTEPLA LGQWHKVSAE RINKDGTLQV
DSSKPVKRSS PGKSQGLNLR TPMYLGGVDK SVTLPAAASI SSSFHGCIGE MSINGKKVDI
SYSFLESRGV TQCYDSSPCD RRPCLHGATC MPTGEYEFQC LCQDGFRGER CELSEDQCLL
RNPCLNDGKC QANQCLCPAG FSGTYCEQGP VPAALDREWA LEGSGGNDAP GQYGAYFQDG
GYLALPRHVL PRSHPKSPET IELEVRTRSL NGLLLWQGVE EGQNGKAKDF ISLGLRDGHL
VFSYQLGSGE ANIVSEDPIN DGEWHRVTAI REGRRGSIQV DGEELVSGES PGSNVMVNTQ
GSVYIGGAPA IQALTAGKFR SGITGCLKNL VLSSEPGQPP QQPIDLQHHS EAGVNMQECP
S
//
