ID A0A452GSA1_9SAUR Unreviewed; 892 AA.
AC A0A452GSA1;
DT 08-MAY-2019, integrated into UniProtKB/TrEMBL.
DT 08-MAY-2019, sequence version 1.
DT 24-JAN-2024, entry version 21.
DE RecName: Full=Solute carrier family 12 member 9 {ECO:0000256|ARBA:ARBA00019359};
OS Gopherus agassizii (Agassiz's desert tortoise).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Testudinata; Testudines; Cryptodira; Durocryptodira;
OC Testudinoidea; Testudinidae; Gopherus.
OX NCBI_TaxID=38772 {ECO:0000313|Ensembl:ENSGAGP00000004588.1, ECO:0000313|Proteomes:UP000291020};
RN [1] {ECO:0000313|Proteomes:UP000291020}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=28562605;
RA Tollis M., DeNardo D.F., Cornelius J.A., Dolby G.A., Edwards T.,
RA Henen B.T., Karl A.E., Murphy R.W., Kusumi K.;
RT "The Agassiz's desert tortoise genome provides a resource for the
RT conservation of a threatened species.";
RL PLoS ONE 12:e0177708-e0177708(2017).
RN [2] {ECO:0000313|Ensembl:ENSGAGP00000004588.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the SLC12A transporter family.
CC {ECO:0000256|ARBA:ARBA00010593}.
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DR AlphaFoldDB; A0A452GSA1; -.
DR STRING; 38772.ENSGAGP00000004588; -.
DR Ensembl; ENSGAGT00000005374.1; ENSGAGP00000004588.1; ENSGAGG00000003764.1.
DR Proteomes; UP000291020; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0015377; F:chloride:monoatomic cation symporter activity; IEA:InterPro.
DR Gene3D; 1.20.1740.10; Amino acid/polyamine transporter I; 1.
DR InterPro; IPR004841; AA-permease/SLC12A_dom.
DR InterPro; IPR018491; SLC12_C.
DR InterPro; IPR004842; SLC12A_fam.
DR PANTHER; PTHR11827:SF98; SOLUTE CARRIER FAMILY 12 MEMBER 9; 1.
DR PANTHER; PTHR11827; SOLUTE CARRIER FAMILY 12, CATION COTRANSPORTERS; 1.
DR Pfam; PF00324; AA_permease; 1.
DR Pfam; PF03522; SLC12; 1.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000291020};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 56..78
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 90..115
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 136..160
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 180..202
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 209..230
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 274..296
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 308..329
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 349..372
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 401..418
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 424..448
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 460..480
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 58..542
FT /note="Amino acid permease/ SLC12A"
FT /evidence="ECO:0000259|Pfam:PF00324"
FT DOMAIN 553..639
FT /note="SLC12A transporter C-terminal"
FT /evidence="ECO:0000259|Pfam:PF03522"
SQ SEQUENCE 892 AA; 97565 MW; 73B9836F3B7F92C4 CRC64;
MSTESSPLLS YRLFSVVDEG EMPGTQAQEE TPLVRGDMGV AVGPPHPDPA RRLSTFFGVV
VPTVLSMFSI VVFMRVGFVV GHAGFLQSLL MLVVAYVIIL LTVLSICAIC TNGAIQGGGA
YFMISRTLGP EFGGSIGLMF YLANVCACGV YILGLVEAVL DVFGAEGTDP PGARVLPQGY
FYSFLYGSVV LLLCLLVCLV GARIYARAAF LIFLVVNLVL VAIFVSFVAV GPRQVPVARD
ANHTFNTSFT GFRLATLRAN LPAMYSRDYT TNNLMTFATV FAVMFNGCTG IMGGSGELRN
ASSSIPKGTI IAVVYTFIIY FLLFLMTSFT CERTLLKEDY GFFRSINLWP PLVLVGVYAA
SLSASMSSLI GASRILHALA KDDLFGIILA PAKIVSKGGN PWVAVLYTWA LVQLVLFAGK
LNTIAGIVTV FYLVAYAAVD LACLALEWAS APNFRPTFQL FSWHTCLLGI ASCVLMMFLI
SPAGASGSLV LMLALLGFIH LRAPASSWGY ISQALIFHQV RKYLLLLDVR KEHVKFWRPQ
MLLMVANPRS GAQLIHFVND LKKGGLFVLG HVEIGELDTM PSDPIQAHYN FWLSLVDKLN
VKAFVDLTLS PSVRQGTQHL LRITGLGGMK PNTLVLGFYD AFVPDDYFLR DPAFSQAREN
DHFGVDLPAL QAHFPPVRGA GASKALPAAE YVMHKNVCLA RYFPLLDKQR LFSSKAEGCF
VDVWPLNLLR PDTPAYVDVC SLFLLQLACI LTMVSSWRAA CLRLFLCVES GDRGWVAKEE
KLKELLSKLR IKAAIRAVTW DHVVALHGQR LAAGEPFLNS AARQVTDEYL AAVNALVLQQ
GGQVAVRFLY LPRPPADTSM YERYLQQLEI LTRDLGPTLL VHGLTPVTCT EL
//
