ID A0A452GU04_9SAUR Unreviewed; 926 AA.
AC A0A452GU04;
DT 08-MAY-2019, integrated into UniProtKB/TrEMBL.
DT 08-MAY-2019, sequence version 1.
DT 27-MAR-2024, entry version 22.
DE RecName: Full=Anoctamin {ECO:0000256|RuleBase:RU280814};
OS Gopherus agassizii (Agassiz's desert tortoise).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Testudinata; Testudines; Cryptodira; Durocryptodira;
OC Testudinoidea; Testudinidae; Gopherus.
OX NCBI_TaxID=38772 {ECO:0000313|Ensembl:ENSGAGP00000005222.1, ECO:0000313|Proteomes:UP000291020};
RN [1] {ECO:0000313|Proteomes:UP000291020}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=28562605;
RA Tollis M., DeNardo D.F., Cornelius J.A., Dolby G.A., Edwards T.,
RA Henen B.T., Karl A.E., Murphy R.W., Kusumi K.;
RT "The Agassiz's desert tortoise genome provides a resource for the
RT conservation of a threatened species.";
RL PLoS ONE 12:e0177708-e0177708(2017).
RN [2] {ECO:0000313|Ensembl:ENSGAGP00000005222.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004651};
CC Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141, ECO:0000256|RuleBase:RU280814}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141,
CC ECO:0000256|RuleBase:RU280814}.
CC -!- SIMILARITY: Belongs to the anoctamin family.
CC {ECO:0000256|ARBA:ARBA00009671, ECO:0000256|RuleBase:RU280814}.
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DR AlphaFoldDB; A0A452GU04; -.
DR STRING; 38772.ENSGAGP00000005222; -.
DR Ensembl; ENSGAGT00000006084.1; ENSGAGP00000005222.1; ENSGAGG00000004239.1.
DR Proteomes; UP000291020; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0046983; F:protein dimerization activity; IEA:InterPro.
DR InterPro; IPR032394; Anoct_dimer.
DR InterPro; IPR007632; Anoctamin.
DR InterPro; IPR049452; Anoctamin_TM.
DR PANTHER; PTHR12308; ANOCTAMIN; 1.
DR PANTHER; PTHR12308:SF22; ANOCTAMIN-7; 1.
DR Pfam; PF16178; Anoct_dimer; 1.
DR Pfam; PF04547; Anoctamin; 1.
PE 3: Inferred from homology;
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU280814};
KW Reference proteome {ECO:0000313|Proteomes:UP000291020};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW ECO:0000256|RuleBase:RU280814};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|RuleBase:RU280814}.
FT TRANSMEM 305..338
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU280814"
FT TRANSMEM 383..403
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU280814"
FT TRANSMEM 461..486
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU280814"
FT TRANSMEM 506..529
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU280814"
FT TRANSMEM 549..570
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU280814"
FT TRANSMEM 676..698
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU280814"
FT TRANSMEM 726..750
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU280814"
FT TRANSMEM 807..829
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU280814"
FT DOMAIN 55..294
FT /note="Anoctamin dimerisation"
FT /evidence="ECO:0000259|Pfam:PF16178"
FT DOMAIN 297..850
FT /note="Anoctamin transmembrane"
FT /evidence="ECO:0000259|Pfam:PF04547"
FT REGION 1..28
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 870..898
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..16
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 926 AA; 106730 MW; 7C494F52370EEF31 CRC64;
MQRKKIKADD HANLMSEDQN AKGPYYGSLS QAPIEVSELS KPSQATHVTQ STANVFSDGR
TRIDFVLVWE ADPQEQEGQN EETTAESEVP RWRRAVDVHK TWRKKFLNKL QAAGICIEKH
MVQDEKKVVH YVLLNAPWSV LCYYAEDLRL RLPLQALPNQ ASNWSDRVAK QLGVPSLLHE
EVPNLPMDYY TCHFKVNKLA WFLGSNEQDT FFSSTQRHRI LYEILATTPY GHLKQGEVGV
DRLLSENVFA AAFPLHEGPF AVPADRLAPE SLTERQVLFQ YWARWQKWNR YQPLDHIRRY
FGEKIALYFA WLGFYTGWLL PAAVVGTLVF IAGIFLMLSD IPAQEICESE DQYQMCPLCK
ECPQWQLSSI CSMFKAGRLF DHGGTIFFSI FMSLWAVTFL EYWKRMNATL AHRWDCSDFE
DIEERPRPQF TAMAPMTMEN PITGAEEPYF PKRNRVKRVT AGLMVIIMMI AVVVMFLISI
ILYRAIVSIL VSRSGNFLFV ASASRIASLT GSVVNLIFIL ILSKIYIALA HFLTKWEMHR
TQTKYEDAFT FKVFVFQFVN FYSSPIYIAF FKGRFVGYPG HYKTLLGIRN EDCGAGGCLT
ELAQELLVIM VGKQVINNVQ EIVIPKLKGW WQKYKLRSKK RKSKEAQLGL AQQVPWESNY
ELLVCEGLFD EYLEMVLQFG FITIFVAACP LAPLFALLNN WVEIRLDAQK FVCEYRRPVA
ERAQGIGIWF YILEVITHLA VISNAFLIAF TSDFLPRLYY QYTRASDLQG YVNFTLAYAP
KHFASQHNVT CRYRAYRDEN GRYSLTYWNL LAIRLGFIIV FEHVVFFIAR VIDLMVPDIP
ESLEIKVKRE RYLAKQALAE NQALFEREEV RATSTTMQTA PKDWELGGMH ENQGPSHLQM
TTSTHTVAAS LEAHPQQQFE PEAESP
//
