ID A0A452GVE5_9SAUR Unreviewed; 4440 AA.
AC A0A452GVE5;
DT 08-MAY-2019, integrated into UniProtKB/TrEMBL.
DT 08-MAY-2019, sequence version 1.
DT 27-MAR-2024, entry version 20.
DE RecName: Full=HECT domain-containing protein {ECO:0000259|PROSITE:PS50237};
OS Gopherus agassizii (Agassiz's desert tortoise).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Testudinata; Testudines; Cryptodira; Durocryptodira;
OC Testudinoidea; Testudinidae; Gopherus.
OX NCBI_TaxID=38772 {ECO:0000313|Ensembl:ENSGAGP00000006098.1, ECO:0000313|Proteomes:UP000291020};
RN [1] {ECO:0000313|Proteomes:UP000291020}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=28562605;
RA Tollis M., DeNardo D.F., Cornelius J.A., Dolby G.A., Edwards T.,
RA Henen B.T., Karl A.E., Murphy R.W., Kusumi K.;
RT "The Agassiz's desert tortoise genome provides a resource for the
RT conservation of a threatened species.";
RL PLoS ONE 12:e0177708-e0177708(2017).
RN [2] {ECO:0000313|Ensembl:ENSGAGP00000006098.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
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DR STRING; 38772.ENSGAGP00000006098; -.
DR Ensembl; ENSGAGT00000007104.1; ENSGAGP00000006098.1; ENSGAGG00000004165.1.
DR Proteomes; UP000291020; Unassembled WGS sequence.
DR GO; GO:0004842; F:ubiquitin-protein transferase activity; IEA:InterPro.
DR CDD; cd13735; SPRY_HECT_like; 1.
DR Gene3D; 2.60.120.920; -; 1.
DR Gene3D; 3.30.2160.10; Hect, E3 ligase catalytic domain; 1.
DR Gene3D; 3.30.2410.10; Hect, E3 ligase catalytic domain; 1.
DR Gene3D; 3.90.1750.10; Hect, E3 ligase catalytic domains; 1.
DR InterPro; IPR043136; B30.2/SPRY_sf.
DR InterPro; IPR000569; HECT_dom.
DR InterPro; IPR035983; Hect_E3_ubiquitin_ligase.
DR InterPro; IPR043366; HECTD4.
DR InterPro; IPR035781; SPRY_HECTD4.
DR PANTHER; PTHR46435; E3 UBIQUITIN-PROTEIN LIGASE HECTD4-RELATED; 1.
DR PANTHER; PTHR46435:SF1; E3 UBIQUITIN-PROTEIN LIGASE HECTD4-RELATED; 1.
DR Pfam; PF00632; HECT; 1.
DR SMART; SM00119; HECTc; 1.
DR SUPFAM; SSF56204; Hect, E3 ligase catalytic domain; 1.
DR PROSITE; PS50237; HECT; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000291020};
KW Ubl conjugation pathway {ECO:0000256|ARBA:ARBA00022786,
KW ECO:0000256|PROSITE-ProRule:PRU00104}.
FT DOMAIN 4056..4440
FT /note="HECT"
FT /evidence="ECO:0000259|PROSITE:PS50237"
FT REGION 1913..1942
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2033..2053
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2639..2665
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 3279..3332
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 3746..3822
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1913..1927
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1928..1942
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2033..2048
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 3279..3306
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 3746..3763
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 3792..3822
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT ACT_SITE 4408
FT /note="Glycyl thioester intermediate"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00104"
SQ SEQUENCE 4440 AA; 488291 MW; 3754B98634914FFC CRC64;
MGSPAAAAAA DSAQWLSVKE ETIFLHDGLI RVTDLAELPS EIIGVAEPGD TELEILTFET
KNPTELAERL RSVCGNQSNA YARLLEYRLN ALRGLWNAQR QLALEEQHER ENSGDEETLA
LLKRQGLLQQ PEQAPFTSRM GLLLVFPLIQ SQSRTDPSLC NITAEVLLNC LRDCQPLSLT
KEPADCLNGI ESLLCSWLEE TSASGQQIPY KQKENAAAAL VALACARGSL KTFVHTVHLL
QKQTDLGSLP VADVLYRLLL LEGGPGSPSC LLGGKHMVSW GFEDMLPAPD ANSGSSSENK
DADLGRCLAA DGLYLYTTNS VGRGISKLGS GLHGTLRGFV YCRNEELETG WVAFGNGKLL
HRPVSFDNKP HSLFQVIDQN TLQVCHILPM PVNHFPVGST MTTVHLSSDG TYFYWIWSPA
SLNEKTPKGH SVFMDIFELI VENDICIANP LQERIILMRK EGESAKSINE MLLSRLSRYR
ASPSATLAAL TGSTISNTLK EDQAAANTSC GLPLKMLRKT PMYTCGTYLV MLVPPPGGSG
SSATRSLFGG TSGLSSLKIL ASSLVYNISD GQFTSRADLI DAAGSSLGRG ALIPGLGACY
DTRNNMIWTC SNDYIDQWCN PGNQAFHYVC QRLGVSHIIT EPRGDAITTS EVINQLLHHV
GAMCIHQLNL LAASNNLPIT NFLGKQHPIE AHHLSSICDI MEKAMVNGDT CIIRCILVVF
QVVFKFFFSP QTERNRDIVR RSGLLLWQLL MAPKSQICPE IQKEVCLAIS SGLNILYPGE
VEINNLLKLV LTEGERNSGL SQLRDVILTN LAEQLQNNRF GSEDDDHYRL NDELLHYILK
IVVRESCFLI TKCQIVSKDE FQRLLSTVPA ASSCLRYLMA VQNHLLSNTI LIKPDENDDS
DSSLQGETLK VQELKTSILA LATQILTGCD EVLEMLQQVT TALINSDISD REQRLKGLEQ
VTKATMLGHL LPVLLTSLMH PNLQTLTMAD ALMPQLVQLV LYTSQTALLL KTQSPVFSEV
GSSPSGTSEQ KGKLFPEERM LEEKEEPGFL TGLKIPAPWA AGKTVETVHP VRDNYKFKET
VHIPGARCLY LRFDSRCSSQ YDYDKLVIYA GPNTNSRKVA EYGGNTLGYG SRSVLGTGWP
KDLVKVEGDI VTFSFEMRSG REHNTPDKAM WGFACTVRAQ ESSEDVSGGL PFLVDLALGL
SVLACSMLRI LYNGPEITKD EETCQELLRS KLLQRCQWQV EANGVISPAL TPSPSPLPLT
IDEDREFTYP SDVLVPPVGH YFDLPRIRLP PGIMIKLREI SGRARPQFRP SIKEVIQPDV
MEEMVVSCVI KHLNLVDALQ SLINFQYQEE HAEEYDLLCK IMGETFKKLN AMERQLQSVA
ELEQRWQNEV DDAIHGKLEN NVPFFYDYHF NESKMKELEL LCSMKEISFD GSDLENMVLS
LREKFFQEVN SLIQKPSHPL AKTKTLVKSL MNRAELLLHV TIAAQAGITR SISGTPAETP
ACKSASETKV ISHAVRQPVF LRSMSAPSDL EMIGNEDLEF TRSSQRRRHV TSHRSSSFTL
LQSLTVEDSR DKPTYSVLLG QLFAFIGTNP DQAVSSSSFL LAAQTRWRRG NTRKQALVHM
RELLTAAVRV GGVTHLVGPV TMVLQGGPRI EELTCGGMVE QVQEAFGETM TSVVSLCARY
PIACANSIGL LCTIPYTRSE EKCLVRSGLV QLMDRLCSLS SQTESSSNEK QTKKQKVATM
AWAAFQVLAN RCVEWEKEEG GSTEAVHSGL ARQVSSLLTN HLARATECCG NQAAGNDALQ
DVLSLLNDLS RSHIGKAILS QPACVSKLLS LLLDQRPSPK LVLIILQLCR AALPLMSVED
CGNVELPPWS YSVPSLNSEQ DDPSDPASKI ASLLLAKLAD YVVPGCQTVL SPTASEPDTT
LAKTSPKNSI KGDKDPGEES EAVDGKLSIF IHKREDQSSH EVLQPLLSSS EGRPFRLGTG
ANMEKVVKMD RDMTKSGCCE VITEEAAAAL RKATKWAQSG LIVSVGPPIE SISPETTSGL
STGDKKKTAQ TSICRERNSE LARTDPVRPF ISGHVANSMA AEVIALLHSL LMAPESNAAQ
IWTTTAEKVL SRALMYIPQL GKYAESILEN GSSSGRKLAK LQRIARQAVA ALCALGGFKE
TIKIGSEVQV LGRGIAGSIG VVASINEQEG IATVKFPPAS IDCRKTSQAS DILTIPLSRL
CVPRSEALPL HKLSITEKVV QAVQSMLLPQ EGSLSIHTSL PATGDGSTPV MAVVRLLGEI
RTRACLVMAQ LLEDSLFCEE FIQQCPAAVE VLNLVAQECS PGERLLIVEV QCERLRMLYR
DCARPPPPPL QADRRQPKEI TWSPSRVFPP VRACMFSSHL TAVTFLADPS AGGGLPRGTF
IYATSPVPVQ APSFYWEIEI VSYGDTDDDT GPIVSFGFAT EAEKRDGAWT NPVGTCLFHN
NGRAVHYNGS SLLQWKSVRL DVTLSPGDIA GIGWERTEGT PPPPGQPAKG RVYFTYCGQR
LGPYLEDVSS GMWPVVHIQK KNTKVRANFG SRQFAYAEGQ AHRNAADLCI DLAEEISANF
EALPFAMASD SDNDAGTSIA SDSGTHGPPC RIAAVATAQQ QYDSDTSCHY KMELSYENFF
TSGPDPHPPA IADDESDDDD DDDVPREDHY ALLVKAWETK VFPTIRRRFR NEAERKSGLD
QIKGALQLGM VDIARQTVEF LYEENGGIPR DLYLPTIEDI KDEANKFTID KVRKGLTVVT
RSPDSNNVAS NAVGTALPKF AIRGMLKTFG LHGVVLDVDS VNELVQVETY LRSEGVLVRY
WYPIDMLERP PAGYRRTATN GLVTLDNTNI QIHRELLRCE ASLARLYCRM ALLNIFAPKS
PHMFTRLFHI PAIRDITLEH LQLLSNQLLA PPLPDGTISS SSILLAQSLQ HCIHSQNCSA
TDLFYQGNSQ QIREWLTVAI TRTLHQGEES LLELTKQICS FLQTAPEQFP AEEFTISESK
VNMDVNFPGA AFVVVSCKES QSGFRKDSSL YKAPWARVFV YGLGHKIKRN GQLNLTEAVC
YPRDASPTNT GLTPPPTTNQ YPSVIISTDK VHIKLGVSPP PGAVLVLHSL PLEFPLALAF
TEQLLTWKSE DGDVKSEDEL DTIPASVLLQ MVELLGNFLW TTDMAACVKE LIFHLLGELL
RKIHNLEQKK NPAGLSSSIA LQLNPCLAML MALQSELHKL YDEETQNWVS GNACGGSGVG
AADQGRFSTY FHALMEGCLA VAEVTLPINM SVTASVMSST NAPNLSDSSS SSSSSPGQTP
QSPSLLSKRK KVKMKREKTS SSGKRSSSQA AETDTAILNI GGSKPEDMLW FHRALTLLII
LRHLTKKDPQ GLGVTNDAVA DACQALVGAT AHSRLLVISG IPTHLEEGIV RSAIRKACNA
HGGVFKDEIY IPLQEEDPKK IKDKAGGGEC RTELEKATVS SSADSLDISS SSSVTPAMSV
SASASTSQAS LCSSQGISRT ISDISVDQFQ ASLELAIPPG LLEPHVVSSQ ESLDLSLCST
GSLGSLGSLG EPLDNVETAS VSDVGSMYTV TSLDNQPLMS RPIKGFAVVE IRSRAKIEKI
RASLFNSSDL IGLSSLDGED ELMEMSTEEI LTVSTVNQSL FDTQGSPVLE DYFNDKSIKG
EKLVPGAREV LSEIFKSCVH SEQTLSLTPA KPIKVADIYL SKEQINSQTP GNLLHVFFTN
VRPPKKVLED QLTQILRKYG VPKPKFDKGK YNKAGKEQHP VKVVSSKRPV TKPPAKEKSV
LNNVSRTALS EKKPTVKPKS PEKGKPDEKD PEKSPTKKQE VPEEKYLTLD GFHRFVVDRA
KQDIRSVWRA ILSCGYDLHF DRCACIDTRH AQKASRKWTL EMDVALVQYI NRLCRHLAIT
PARLHPHEVY LDPADAADPR VSCLLNVPIE SLRLRFALLQ SLNTMLETFF LPLVELRQTE
MYTNSIAALL QEAKGLIFYD TKVTVMNRVL NATVQRTADH AAPEITLDPL EIVGGEIRSS
ENSYFCQAAR QLACVPSSQL CVKLASGGDP TYAFNIRFIG EEVHGTSGSF RHFLWQVCKE
LQSSSLSLLL LCPSSAVNKN KVRYPHGKLI EKCFTLTKDT VCLISRGKYI LTPSPITYAE
EQLLHFFGHL LGIAVRADVP LPLDLLPSFW KTLVGEPLDP DVDLQEADIL TYNYVKKFEN
INDETELEAL CAEIASQHLA TESPDYPNKP CCKFTYLSMT GEEVELCPRG RHIPVIWENK
DIYATAVRNL RLHELQNPDC MTAVRAGLGS IIPLQLLTTL TPLEMELRTC GLPYINLEFL
KAHTMYQVGL METDQHIEFF WGALEMFTQE ELCKFIKFAC NQERIPFTCP CKDGGPDTAH
VPPYPMKIAP PDGAAGSPDS RYIRVETCMF MIKLPQYSSL DIMLEKLRYA VHYREDPLSG
//
