ID A0A452GVX8_9SAUR Unreviewed; 1478 AA.
AC A0A452GVX8;
DT 08-MAY-2019, integrated into UniProtKB/TrEMBL.
DT 08-MAY-2019, sequence version 1.
DT 27-MAR-2024, entry version 20.
DE RecName: Full=Plexin A4 {ECO:0008006|Google:ProtNLM};
OS Gopherus agassizii (Agassiz's desert tortoise).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Testudinata; Testudines; Cryptodira; Durocryptodira;
OC Testudinoidea; Testudinidae; Gopherus.
OX NCBI_TaxID=38772 {ECO:0000313|Ensembl:ENSGAGP00000006206.1, ECO:0000313|Proteomes:UP000291020};
RN [1] {ECO:0000313|Proteomes:UP000291020}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=28562605;
RA Tollis M., DeNardo D.F., Cornelius J.A., Dolby G.A., Edwards T.,
RA Henen B.T., Karl A.E., Murphy R.W., Kusumi K.;
RT "The Agassiz's desert tortoise genome provides a resource for the
RT conservation of a threatened species.";
RL PLoS ONE 12:e0177708-e0177708(2017).
RN [2] {ECO:0000313|Ensembl:ENSGAGP00000006206.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR Ensembl; ENSGAGT00000007215.1; ENSGAGP00000006206.1; ENSGAGG00000004151.1.
DR Proteomes; UP000291020; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0017154; F:semaphorin receptor activity; IEA:InterPro.
DR CDD; cd00603; IPT_PCSR; 1.
DR CDD; cd01180; IPT_plexin_repeat1; 1.
DR CDD; cd01179; IPT_plexin_repeat2; 1.
DR CDD; cd01181; IPT_plexin_repeat3; 1.
DR CDD; cd12790; RasGAP_plexin_A; 1.
DR Gene3D; 2.60.40.10; Immunoglobulins; 5.
DR Gene3D; 2.130.10.10; YVTN repeat-like/Quinoprotein amine dehydrogenase; 1.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR014756; Ig_E-set.
DR InterPro; IPR002909; IPT_dom.
DR InterPro; IPR031148; Plexin.
DR InterPro; IPR013548; Plexin_cytoplasmic_RasGAP_dom.
DR InterPro; IPR046800; Plexin_RBD.
DR InterPro; IPR002165; Plexin_repeat.
DR InterPro; IPR016201; PSI.
DR InterPro; IPR008936; Rho_GTPase_activation_prot.
DR InterPro; IPR036352; Semap_dom_sf.
DR InterPro; IPR041019; TIG1_plexin.
DR InterPro; IPR041362; TIG2_plexin.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR PANTHER; PTHR22625; PLEXIN; 1.
DR PANTHER; PTHR22625:SF34; PLEXIN-A4; 1.
DR Pfam; PF08337; Plexin_cytopl; 1.
DR Pfam; PF20170; Plexin_RBD; 1.
DR Pfam; PF01437; PSI; 3.
DR Pfam; PF01833; TIG; 4.
DR Pfam; PF18020; TIG_2; 1.
DR Pfam; PF17960; TIG_plexin; 1.
DR SMART; SM00429; IPT; 4.
DR SMART; SM00423; PSI; 3.
DR SUPFAM; SSF81296; E set domains; 4.
DR SUPFAM; SSF48350; GTPase activation domain, GAP; 1.
DR SUPFAM; SSF103575; Plexin repeat; 2.
DR SUPFAM; SSF101912; Sema domain; 1.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000291020};
KW Signal {ECO:0000256|ARBA:ARBA00022729};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 822..844
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 92..142
FT /note="PSI"
FT /evidence="ECO:0000259|SMART:SM00423"
FT DOMAIN 238..285
FT /note="PSI"
FT /evidence="ECO:0000259|SMART:SM00423"
FT DOMAIN 386..439
FT /note="PSI"
FT /evidence="ECO:0000259|SMART:SM00423"
FT DOMAIN 440..534
FT /note="IPT/TIG"
FT /evidence="ECO:0000259|SMART:SM00429"
FT DOMAIN 536..621
FT /note="IPT/TIG"
FT /evidence="ECO:0000259|SMART:SM00429"
FT DOMAIN 623..723
FT /note="IPT/TIG"
FT /evidence="ECO:0000259|SMART:SM00429"
FT DOMAIN 725..814
FT /note="IPT/TIG"
FT /evidence="ECO:0000259|SMART:SM00429"
FT COILED 848..875
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 1478 AA; 166100 MW; F2194B73FA2E65B2 CRC64;
PTTPSLYSGL IRWYPVCKLI PVLQKGRHSC SLSPFALALQ IRVDGPTNGA LEYEIVQVVD
TGPILRDMVF SVDHEHLYIM SEKQLARVPV ESCGQYKTCS TCLGSGDPHC GWCVLHNTCT
RKEQCERSSE PRRFASEMKQ CVRLTVHPNN ISVSQYNVLL VLETYNVPEL SAGVNCTFED
LSEMDGLVVG NQIQCISPAA KEVPQIIMEN GDHHIVQLQL KSKETGMTFA STSFVFYNCS
VHNSCLSCVE SPYRCHWCKY RHVCTHDPRS CSFQEGRVKL PEDCPQLLQA DKILVPVEVI
KPITLKAKNL PQPQSGQRGY ECILNIQGNE QRVPALRFNS SSVQCQNTSY SYEGMEINSL
PVELTVVWNG NFNIDNPAQN KVHLYKCGAM RDSCGLCLKA DPDFECGWCE GQNQCTLKHH
CPIPENQWLE LSGTKGKCTN PRITDIIPVT GPREGGTKVT IRGENLGLEF RDIASHVKVA
GVECKPLVEG YIPAEQIVCE MGEAKPSQHA GFVEICVAEC KPEFMARSSQ LYYFMTLTLS
DLKPKRGPVS GGTQVTITGT NLNAGSNVVV TFGRQPCLFY RRSTKYIVCN TTASDDGFDK
VKVSVRVDKA KIHQELQFEY IEDPTILRIE PEWSIISGNT PIAVWGTHLD LIQNPQIRAK
HGGKEHVNIC EVQNATEMTC QAPALAMDPN HQSELTERPE EFGFILDNVQ SLLMLNKTNF
TYYPNPVFEA FNPSGILELK PGTPIILKGK NLIPPVTGGN AKLNYTVLIG EKPCVVTVSD
VQLLCESPNL IGRHKVMARV GGLEFSPGMV YISPDSLLSL PAIVSITVAG GLLIIFIVAV
LIAYKRKSRE SDLTLKRLQM QMDNLESRVA LECKEAFAEL QTDIHELTSD LDGAGIPFLD
YRTYTMRVLF PGIEDHPVLR DLEVPGYRQE RVEKGLKLFA QLINNKVFLL SFIRTLESQR
SFSMRDRGNV ASLIMTVLQS KLEYATDVLK QLLADLIDKN LESKNHPKLL LRRTESVAEK
MLTNWFTFLL YKFLKECAGE PLFSLFCAIK QQMEKGPIDS ITGEARYSLS EDKLIRQQID
YKTLVLSCVN PDNVNSPEIP VKILNCDTIT QVKEKILDAI FKNVPCSHRP KAADMDLEWR
QTSGARMILQ DEDITTKIEN DWKRLNTLAH YQVPDGSVVA LVSKQVTAYN AVNNSTVSRT
SASKYENMIR YTGSPDSLRS RTPMITPDLE SGVKMWHLVK NHEHGDQKEG DRGSKMVSEI
YLTRLLATKG TLQKFVDDLF ETIFSTAHRG SALPLAIKYM FDFLDEQADK HNIHDPHVRH
TWKSNCLPLR FWVNMIKNPQ FVFDIHKNSI TDACLSVVAQ TFMDSCSTSE HRLGKDSPSN
KLLYAKDIPS YKNWVERYYS DIGKMPAISD QDMNAYLAEQ SRMHMNEFNT MSALSEIYSY
VGKYSEEILG ALDQDDQAGK QKLAYKLEQV ITLMSIDS
//
