ID A0A452GXL9_9SAUR Unreviewed; 553 AA.
AC A0A452GXL9;
DT 08-MAY-2019, integrated into UniProtKB/TrEMBL.
DT 08-MAY-2019, sequence version 1.
DT 27-MAR-2024, entry version 20.
DE RecName: Full=SHC adaptor protein 2 {ECO:0008006|Google:ProtNLM};
OS Gopherus agassizii (Agassiz's desert tortoise).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Testudinata; Testudines; Cryptodira; Durocryptodira;
OC Testudinoidea; Testudinidae; Gopherus.
OX NCBI_TaxID=38772 {ECO:0000313|Ensembl:ENSGAGP00000006893.1, ECO:0000313|Proteomes:UP000291020};
RN [1] {ECO:0000313|Proteomes:UP000291020}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=28562605;
RA Tollis M., DeNardo D.F., Cornelius J.A., Dolby G.A., Edwards T.,
RA Henen B.T., Karl A.E., Murphy R.W., Kusumi K.;
RT "The Agassiz's desert tortoise genome provides a resource for the
RT conservation of a threatened species.";
RL PLoS ONE 12:e0177708-e0177708(2017).
RN [2] {ECO:0000313|Ensembl:ENSGAGP00000006893.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
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DR AlphaFoldDB; A0A452GXL9; -.
DR Ensembl; ENSGAGT00000007995.1; ENSGAGP00000006893.1; ENSGAGG00000005552.1.
DR Proteomes; UP000291020; Unassembled WGS sequence.
DR GO; GO:0035556; P:intracellular signal transduction; IEA:InterPro.
DR CDD; cd01209; PTB_Shc; 1.
DR CDD; cd09925; SH2_SHC; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR Gene3D; 3.30.505.10; SH2 domain; 1.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR006019; PID_Shc-like.
DR InterPro; IPR006020; PTB/PI_dom.
DR InterPro; IPR000980; SH2.
DR InterPro; IPR036860; SH2_dom_sf.
DR InterPro; IPR035676; SHC_SH2.
DR PANTHER; PTHR10337; SHC TRANSFORMING PROTEIN; 1.
DR PANTHER; PTHR10337:SF5; SHC-TRANSFORMING PROTEIN 2; 1.
DR Pfam; PF00640; PID; 1.
DR Pfam; PF00017; SH2; 1.
DR PRINTS; PR00401; SH2DOMAIN.
DR PRINTS; PR00629; SHCPIDOMAIN.
DR SMART; SM00462; PTB; 1.
DR SMART; SM00252; SH2; 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR SUPFAM; SSF55550; SH2 domain; 1.
DR PROSITE; PS01179; PID; 1.
DR PROSITE; PS50001; SH2; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000291020};
KW SH2 domain {ECO:0000256|ARBA:ARBA00022999, ECO:0000256|PROSITE-
KW ProRule:PRU00191}.
FT DOMAIN 133..315
FT /note="PID"
FT /evidence="ECO:0000259|PROSITE:PS01179"
FT DOMAIN 458..549
FT /note="SH2"
FT /evidence="ECO:0000259|PROSITE:PS50001"
FT REGION 41..63
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 425..451
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 553 AA; 60678 MW; CBC7B06DEE45910D CRC64;
SLPGPGGASV EQEAVTTFCM LIPKIPQWKF SSASGFLSRS PSSASKDLSS PAKPGGHGEA
EGSSSGLAAV LSACEPVCHS PCSLQVMNRF RGGGGRKAAR VEGVKLAGEE WNRKGSFINK
PAQGWLHPDE RVLGPGVSYI VRYMGCIEVL RSMRSLDFNT RTQVTREAIN RLYEAVPGVK
GAWKKKAPNK ALFSILGKNN LHFAGMSITV NISIDGLNLM IPTTRQIIAN HHMQSISFAS
GGDTDMTDYV AYVAKDPINQ RACHILECCD GLAQSIINTV GQAFELRFKQ YLHSPPKVVV
PPDRVMGTEE SAWGNEEETA EHDYYNSIPG KEPPLGGLID SRLRHTTLVP GAGPGLEARL
CLPGQSCDGY LQADSQPLGC RDYEEHMYVN TQCLDGWEHE ASPPKDLFDM RPFEDALKLH
ESTVAGGASP PLEDQWPSPP TRKAPIAPTE EQLKREPWYH GKMSRRDAEK LLQMDGDFLV
RDSITNPGQY VLTGMNSGQP KHLLLVDPEG VVRTKDVLFE SISHLINYHL QNEQPIVAAE
SELHLRQVVK RKQ
//
