ID A0A452GYQ8_9SAUR Unreviewed; 429 AA.
AC A0A452GYQ8;
DT 08-MAY-2019, integrated into UniProtKB/TrEMBL.
DT 08-MAY-2019, sequence version 1.
DT 27-MAR-2024, entry version 23.
DE RecName: Full=tRNA (guanine(10)-N2)-methyltransferase homolog {ECO:0000256|ARBA:ARBA00013960};
DE AltName: Full=tRNA guanosine-2'-O-methyltransferase TRM11 homolog {ECO:0000256|ARBA:ARBA00032604};
OS Gopherus agassizii (Agassiz's desert tortoise).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Testudinata; Testudines; Cryptodira; Durocryptodira;
OC Testudinoidea; Testudinidae; Gopherus.
OX NCBI_TaxID=38772 {ECO:0000313|Ensembl:ENSGAGP00000007245.1, ECO:0000313|Proteomes:UP000291020};
RN [1] {ECO:0000313|Proteomes:UP000291020}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=28562605;
RA Tollis M., DeNardo D.F., Cornelius J.A., Dolby G.A., Edwards T.,
RA Henen B.T., Karl A.E., Murphy R.W., Kusumi K.;
RT "The Agassiz's desert tortoise genome provides a resource for the
RT conservation of a threatened species.";
RL PLoS ONE 12:e0177708-e0177708(2017).
RN [2] {ECO:0000313|Ensembl:ENSGAGP00000007245.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- FUNCTION: Catalytic subunit of an S-adenosyl-L-methionine-dependent
CC tRNA methyltransferase complex that mediates the methylation of the
CC guanosine nucleotide at position 10 (m2G10) in tRNAs.
CC {ECO:0000256|ARBA:ARBA00002425}.
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DR AlphaFoldDB; A0A452GYQ8; -.
DR Ensembl; ENSGAGT00000008376.1; ENSGAGP00000007245.1; ENSGAGG00000005813.1.
DR Proteomes; UP000291020; Unassembled WGS sequence.
DR GO; GO:0008168; F:methyltransferase activity; IEA:UniProtKB-KW.
DR GO; GO:0000049; F:tRNA binding; IEA:UniProtKB-KW.
DR GO; GO:0032259; P:methylation; IEA:UniProtKB-KW.
DR GO; GO:0009451; P:RNA modification; IEA:UniProt.
DR GO; GO:0008033; P:tRNA processing; IEA:UniProtKB-KW.
DR Gene3D; 3.40.50.150; Vaccinia Virus protein VP39; 1.
DR InterPro; IPR002052; DNA_methylase_N6_adenine_CS.
DR InterPro; IPR000241; RlmKL-like_Mtase.
DR InterPro; IPR029063; SAM-dependent_MTases_sf.
DR InterPro; IPR016691; tRNA_mtfrase_TRM11.
DR PANTHER; PTHR13370; RNA METHYLASE-RELATED; 1.
DR PANTHER; PTHR13370:SF3; TRNA (GUANINE(10)-N2)-METHYLTRANSFERASE HOMOLOG; 1.
DR Pfam; PF01170; UPF0020; 1.
DR PIRSF; PIRSF017259; tRNA_mtfrase_TRM11; 2.
DR SUPFAM; SSF53335; S-adenosyl-L-methionine-dependent methyltransferases; 1.
DR PROSITE; PS00092; N6_MTASE; 1.
DR PROSITE; PS51627; SAM_MT_TRM11; 1.
PE 4: Predicted;
KW Methyltransferase {ECO:0000256|ARBA:ARBA00022603};
KW Reference proteome {ECO:0000313|Proteomes:UP000291020};
KW RNA-binding {ECO:0000256|ARBA:ARBA00022555};
KW S-adenosyl-L-methionine {ECO:0000256|ARBA:ARBA00022691};
KW Signal {ECO:0000256|SAM:SignalP};
KW Transferase {ECO:0000256|ARBA:ARBA00022679};
KW tRNA-binding {ECO:0000256|ARBA:ARBA00022555}.
FT SIGNAL 1..16
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 17..429
FT /note="tRNA (guanine(10)-N2)-methyltransferase homolog"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5019233070"
FT DOMAIN 203..334
FT /note="UPF0020"
FT /evidence="ECO:0000259|Pfam:PF01170"
SQ SEQUENCE 429 AA; 49475 MW; ADF7463BBB238C35 CRC64;
MRGWAERFMA SGGAMARGLL PSYLLLLAQE NLEFRLPEIK SLLSLCGGQF SSQQEIRINS
PFWILNIPSE EMARGLMKRT VCAKSVFELW GQGKSAEELY TSLKNYPMEK MVPYLQSNST
YKIHIHAFNK TLTQDKKIRR IDALEFLPFE GKVNLKNPEH IFWILEDYGM DPNNVPEDPL
DLYFGRWIAN GQRELIESYS VKRRHFIGNT SMDACLSFIM ANHGRVKAND VVFDPFVGTG
GLLISSARFG AYVCGTDIDY NTVHGLGKAS RKNQKWRGPD ENIRANLRQY GLEKYYLDAL
VSDASKPIWR KEMLFDAIIT DPPYGIREAT RRTGSQKEIL KATERGYTEE IIPRHPCLKL
ISNCEQMLSS HTSRRLITME KVKEFEDEDQ YSHLLDYQSL LYKGHNSFRE KYFSGVTKRI
AKEEKDNQK
//
