ID   A0A452GZV7_9SAUR        Unreviewed;      1149 AA.
AC   A0A452GZV7;
DT   08-MAY-2019, integrated into UniProtKB/TrEMBL.
DT   08-MAY-2019, sequence version 1.
DT   24-JAN-2024, entry version 21.
DE   RecName: Full=UNC-45/Cro1/She4 central domain-containing protein {ECO:0000259|Pfam:PF11701};
OS   Gopherus agassizii (Agassiz's desert tortoise).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Archelosauria; Testudinata; Testudines; Cryptodira; Durocryptodira;
OC   Testudinoidea; Testudinidae; Gopherus.
OX   NCBI_TaxID=38772 {ECO:0000313|Ensembl:ENSGAGP00000007685.1, ECO:0000313|Proteomes:UP000291020};
RN   [1] {ECO:0000313|Proteomes:UP000291020}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=28562605;
RA   Tollis M., DeNardo D.F., Cornelius J.A., Dolby G.A., Edwards T.,
RA   Henen B.T., Karl A.E., Murphy R.W., Kusumi K.;
RT   "The Agassiz's desert tortoise genome provides a resource for the
RT   conservation of a threatened species.";
RL   PLoS ONE 12:e0177708-e0177708(2017).
RN   [2] {ECO:0000313|Ensembl:ENSGAGP00000007685.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2023) to UniProtKB.
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DR   AlphaFoldDB; A0A452GZV7; -.
DR   STRING; 38772.ENSGAGP00000007685; -.
DR   Ensembl; ENSGAGT00000008869.1; ENSGAGP00000007685.1; ENSGAGG00000006144.1.
DR   Proteomes; UP000291020; Unassembled WGS sequence.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR   Gene3D; 1.25.10.10; Leucine-rich Repeat Variant; 2.
DR   Gene3D; 2.130.10.30; Regulator of chromosome condensation 1/beta-lactamase-inhibitor protein II; 1.
DR   InterPro; IPR011989; ARM-like.
DR   InterPro; IPR016024; ARM-type_fold.
DR   InterPro; IPR009091; RCC1/BLIP-II.
DR   InterPro; IPR000408; Reg_chr_condens.
DR   InterPro; IPR024660; UCS_central_dom.
DR   PANTHER; PTHR45994; FI21225P1; 1.
DR   PANTHER; PTHR45994:SF3; PROTEIN UNC-45 HOMOLOG A; 1.
DR   Pfam; PF00415; RCC1; 1.
DR   Pfam; PF11701; UNC45-central; 1.
DR   SUPFAM; SSF48371; ARM repeat; 2.
DR   SUPFAM; SSF50985; RCC1/BLIP-II; 1.
DR   PROSITE; PS00626; RCC1_2; 2.
DR   PROSITE; PS50012; RCC1_3; 2.
PE   4: Predicted;
KW   Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW   Reference proteome {ECO:0000313|Proteomes:UP000291020}.
FT   DOMAIN          268..455
FT                   /note="UNC-45/Cro1/She4 central"
FT                   /evidence="ECO:0000259|Pfam:PF11701"
FT   REPEAT          958..1009
FT                   /note="RCC1"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00235"
FT   REPEAT          1010..1104
FT                   /note="RCC1"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00235"
FT   REGION          1..34
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   1149 AA;  124772 MW;  2700CB0F3224D888 CRC64;
     MCEPGAQEQG FPGGIARSGE QHAGEGKHQR SRSKAWARAL EGQYSQRCWP LRGLVLPASW
     PRPGRVTDPS AGRGSHCRVI EAVTNLFLHL SQMKLMSCTD SKVEQMFQIL LDPKETDTDK
     KQKAAQNLIV LAREEAGAEK IFQSDGVRLL LRMLDTGRED AMLAALRTLA GLCSGHRSRT
     MAILAELGAP RVSAMLGVEH EQVSLAACNL LQVMFDALKE GLQRDFRGKE EALVLDPSKE
     LKLLIGHLLE MLNREGTSAH GRDNILNLLI KVVPRKSLRD PNNSLTLWVI DQGLKKILEV
     GGTVCEAPGS LPATENSRMS AAVLLSKLYS DLKCDAEREN FHRLCEDYVR SWFEGHGLAG
     KLRAIQTASC LLQGPSEAGN QVLELEGIME SVLALCASVR EVDQLVAVEA LIHAADKAKR
     ASFITANGVT LLKNIYKCSG RDSIRIRALV GLCKLGSAGG IDFSMKQFAE GSTLKLAKQC
     RKWLCNEAID AGTRRWAVEG LAYLTFDADV KEEFVEDKAA VQAMFQLAKS EDKSVLFAVA
     STLVNCTNSY DHEEPDPQML ELAKYAKQHV PEQHPKDEPG CVRRRVRKLL AAGVVSALTC
     MVKSENPALT NSCRELISRV FLAVVEEAAD RGSVVAQGGG KALIPLSLEG TEVGQAKAAQ
     ALAKITITSN PDMAFPGERI YEVVRPLVRL LHLHRTGLEN FEGLMALTNL AGISERLRQK
     ILKEKAVPMI EGYMFEEHEL LRLAATECMC NMAMSTEVQE LFLAEGSDRL KLLVLYSGED
     DEKLRRAASG TLAMLTSLLP QICGKITQVT AHWLEILQAL LLSPNVELQH RGAVIVLNMM
     VADREIAAKL MERHGRLVLG GWLAGALPGH CQDLLPSESH VLLLRGTALE AWARGAGLCQ
     GPSWQQQLHP GEAARPLPLA PCGYMIPRPP FLCPLPPALR AQKLVLGHEH VVLLGQDGTI
     YTWGCGRHGQ LGHGGLEPAL EPRLVEALHG VPMGDVAAGG WHSVSVSEGG DLYVWGWNES
     GQLALPSKAL AEKRAPATAS VSQHEEPCPG EAELKLVNHE AALGAEAADF ISIQAFPALL
     DLPEGSEVSK VSCGSRHTAA VTRKYGQLGH NDTASSDQPR QVGYFPANGL TVEDVVCGPW
     NTYVGAVEK
//