ID A0A452H0Z5_9SAUR Unreviewed; 976 AA.
AC A0A452H0Z5;
DT 08-MAY-2019, integrated into UniProtKB/TrEMBL.
DT 08-MAY-2019, sequence version 1.
DT 24-JAN-2024, entry version 20.
DE SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSGAGP00000008126.1};
OS Gopherus agassizii (Agassiz's desert tortoise).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Testudinata; Testudines; Cryptodira; Durocryptodira;
OC Testudinoidea; Testudinidae; Gopherus.
OX NCBI_TaxID=38772 {ECO:0000313|Ensembl:ENSGAGP00000008126.1, ECO:0000313|Proteomes:UP000291020};
RN [1] {ECO:0000313|Proteomes:UP000291020}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=28562605;
RA Tollis M., DeNardo D.F., Cornelius J.A., Dolby G.A., Edwards T.,
RA Henen B.T., Karl A.E., Murphy R.W., Kusumi K.;
RT "The Agassiz's desert tortoise genome provides a resource for the
RT conservation of a threatened species.";
RL PLoS ONE 12:e0177708-e0177708(2017).
RN [2] {ECO:0000313|Ensembl:ENSGAGP00000008126.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the sorting nexin family.
CC {ECO:0000256|ARBA:ARBA00010883}.
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DR AlphaFoldDB; A0A452H0Z5; -.
DR STRING; 38772.ENSGAGP00000008126; -.
DR Ensembl; ENSGAGT00000009359.1; ENSGAGP00000008126.1; ENSGAGG00000006461.1.
DR Proteomes; UP000291020; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0035091; F:phosphatidylinositol binding; IEA:InterPro.
DR CDD; cd06893; PX_SNX19; 1.
DR Gene3D; 3.30.1520.10; Phox-like domain; 1.
DR InterPro; IPR003114; Phox_assoc.
DR InterPro; IPR001683; PX_dom.
DR InterPro; IPR036871; PX_dom_sf.
DR InterPro; IPR037909; SNX19_PX.
DR InterPro; IPR013937; Sorting_nexin_C.
DR PANTHER; PTHR22775; SORTING NEXIN; 1.
DR PANTHER; PTHR22775:SF31; SORTING NEXIN-19; 1.
DR Pfam; PF08628; Nexin_C; 1.
DR Pfam; PF00787; PX; 1.
DR Pfam; PF02194; PXA; 1.
DR SMART; SM00312; PX; 1.
DR SMART; SM00313; PXA; 1.
DR SUPFAM; SSF64268; PX domain; 1.
DR PROSITE; PS50195; PX; 1.
DR PROSITE; PS51207; PXA; 1.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000291020};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 35..65
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 95..276
FT /note="PXA"
FT /evidence="ECO:0000259|PROSITE:PS51207"
FT DOMAIN 526..656
FT /note="PX"
FT /evidence="ECO:0000259|PROSITE:PS50195"
FT REGION 329..360
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 478..498
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 686..717
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 772..800
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 954..976
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 330..345
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 698..716
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 776..795
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 976 AA; 108354 MW; 211AE915D08B2469 CRC64;
MENQRMLKTQ ESCGSLSSGL GELVGNRKLM VLGALLAWLL VVHLLVNVWL LCLLSGLLVV
LGGWLGSQAI IGTRSRLHLE RFILLENCPQ SPEAEKQLDE EIDHMIQKII RDFVSSWYRT
VCSEPGFEEE VRKAMLGLAL ELKRRMALVD KQALTHKILL LCGCHLQSYM KARESMEAAR
SPAGPAQLAD QLWRAYGKLS APHPAVQSPA MEVNYARSIV DLLLRVLVPK PHLETRTGRF
VVVELVTCNV LLPMIKKMSD PDWINLLLIE IFSKMGSKGV RRGKGEAPPL AASPCQPTVP
NSLPLKVVAP SPRPSELPSY DVVESLECNP QEAEEGKDLM SGEAGADVDG KKAGSTPVRY
PQPDTLGSLL LCEDSELESP MSDLGKDSDS VVLLSTEEFL TDTFQDSFAV LEGSDGLDQE
NHVVTKDAYL EESTASNSER SVLPSALSQC PDIQIDPAVE KEDSLASVTA LLADPEKPFP
RRPSFLENPA KSPLDPSQPP LPLYSSHTFS FEPISSPDSP VIIQNLRITG TITAREHSGT
GFHPYTLYTV KYETALESEN ANNLQQVAYH TVNRRYREFL NLQTRLEEKP ELRKFVKNVK
GPKKLFPDLP FGNMDSDKVE ARKSLLESFL KQLCSIPEIA NSEQVQEFLA LNTDARIAFV
KKPFVVSRID KIVLNAIVDT LKTAFPRSEP QSPTEELSET EVDGKSQTDG KKANKPKLRF
SSSKIAPVLS VAEAHERILY GLREGSTVSD TLSLAGMESF IQKQEKLLEV MSSEASETEG
VGSTQVPQQP VYQKDDPDSE TPLADTALDL LHLLLMDRWS WLCTENMQKV LHLLFGSLIQ
RWLEVQVTNL TCTQRWVQYL RLLQESIWPG GVLPAMPKPF RTQEQKEATA QQALQSLMGL
LPDLILEILG TSRCRLSWNL VLESLHQPIM NRHLVYRLSD ILLEFLILNN SSDGPKTTAV
TSSVSNSPET ASISPH
//
