ID A0A452H264_9SAUR Unreviewed; 889 AA.
AC A0A452H264;
DT 08-MAY-2019, integrated into UniProtKB/TrEMBL.
DT 08-MAY-2019, sequence version 1.
DT 24-JAN-2024, entry version 20.
DE SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSGAGP00000008543.1};
OS Gopherus agassizii (Agassiz's desert tortoise).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Testudinata; Testudines; Cryptodira; Durocryptodira;
OC Testudinoidea; Testudinidae; Gopherus.
OX NCBI_TaxID=38772 {ECO:0000313|Ensembl:ENSGAGP00000008543.1, ECO:0000313|Proteomes:UP000291020};
RN [1] {ECO:0000313|Proteomes:UP000291020}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=28562605;
RA Tollis M., DeNardo D.F., Cornelius J.A., Dolby G.A., Edwards T.,
RA Henen B.T., Karl A.E., Murphy R.W., Kusumi K.;
RT "The Agassiz's desert tortoise genome provides a resource for the
RT conservation of a threatened species.";
RL PLoS ONE 12:e0177708-e0177708(2017).
RN [2] {ECO:0000313|Ensembl:ENSGAGP00000008543.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the formin homology family. Diaphanous
CC subfamily. {ECO:0000256|ARBA:ARBA00008214}.
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DR AlphaFoldDB; A0A452H264; -.
DR Ensembl; ENSGAGT00000009830.1; ENSGAGP00000008543.1; ENSGAGG00000005581.1.
DR Proteomes; UP000291020; Unassembled WGS sequence.
DR GO; GO:0003779; F:actin binding; IEA:InterPro.
DR GO; GO:0031267; F:small GTPase binding; IEA:InterPro.
DR GO; GO:0030036; P:actin cytoskeleton organization; IEA:InterPro.
DR Gene3D; 1.20.58.630; -; 1.
DR Gene3D; 6.10.30.30; -; 1.
DR Gene3D; 1.10.20.40; Formin, diaphanous GTPase-binding domain; 1.
DR Gene3D; 1.20.58.2220; Formin, FH2 domain; 1.
DR Gene3D; 1.10.238.150; Formin, FH3 diaphanous domain; 1.
DR Gene3D; 1.25.10.10; Leucine-rich Repeat Variant; 1.
DR InterPro; IPR011989; ARM-like.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR014767; DAD_dom.
DR InterPro; IPR044933; DIA_GBD_sf.
DR InterPro; IPR015425; FH2_Formin.
DR InterPro; IPR042201; FH2_Formin_sf.
DR InterPro; IPR010472; FH3_dom.
DR InterPro; IPR014768; GBD/FH3_dom.
DR InterPro; IPR010473; GTPase-bd.
DR PANTHER; PTHR45691; PROTEIN DIAPHANOUS; 1.
DR PANTHER; PTHR45691:SF3; PROTEIN DIAPHANOUS HOMOLOG 2; 1.
DR Pfam; PF06367; Drf_FH3; 1.
DR Pfam; PF06371; Drf_GBD; 1.
DR Pfam; PF02181; FH2; 1.
DR SMART; SM01139; Drf_FH3; 1.
DR SMART; SM01140; Drf_GBD; 1.
DR SMART; SM00498; FH2; 1.
DR SUPFAM; SSF48371; ARM repeat; 1.
DR SUPFAM; SSF101447; Formin homology 2 domain (FH2 domain); 1.
DR PROSITE; PS51231; DAD; 1.
DR PROSITE; PS51444; FH2; 1.
DR PROSITE; PS51232; GBD_FH3; 1.
PE 3: Inferred from homology;
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054};
KW Reference proteome {ECO:0000313|Proteomes:UP000291020}.
FT DOMAIN 1..326
FT /note="GBD/FH3"
FT /evidence="ECO:0000259|PROSITE:PS51232"
FT DOMAIN 417..816
FT /note="FH2"
FT /evidence="ECO:0000259|PROSITE:PS51444"
FT DOMAIN 839..869
FT /note="DAD"
FT /evidence="ECO:0000259|PROSITE:PS51231"
FT REGION 335..409
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 802..838
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 348..409
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 889 AA; 101313 MW; 6059DF018D784FD1 CRC64;
MLSAHLQEDM NLNEERKAPL RNKDLTTKRE MVGQYISGGL KNSKHECTLS SQEYVHELRS
GITEEKLFNC LESLRVSLTS NPVSWVNNFG HEGLGLLLDV LERLLDKKQT LGDERSLLLL
ARAIDPKQPN MMTETVKILS AICIVGEENI LDKLLEAITT AAERNNRERF SSVVQGLENH
EALQLQVACM QFINALVTSP EDLDFRIHLR NEFLRCGLKK ILPDLKEKEN EELDIQLKVF
DENKEDDLIE LSHRLNDIKA EMEYPFKNSL IYFILCIFSD TASENYFLSI LQHLLLVRND
YYVRTQYYKI IEECISQIVL HCSGMDPDFK YRGRLDGSLL SAGQPTSGAP PSSPPPPPPP
LPGVIPPPPP PPPPPPLPGG GVPPPPPLFG GPPLLPPFGG IPPPPGAPAS LPYGMKEKKK
YKPEVSMKRI NWSKVEPQDI LENCFWLKVR EDKFENPDLF AKLALTFGTQ MKAKKAVDDT
EEKKVVLPKK RVKELRILDG KTAQNLSIFL GSFRMPYEEI KNIILEVDEK KLSESLIQNL
VKNLPEQKEL SALAQLKHEY DDLCEPEQFG VVMSSVKMLR PRLNGILFKL MFEEHVNNIR
PGIMAVTLAC EELKKSESFN SLLELVLLVG NYMNSGSRNA QSLGFNISFL CKIRDTKSSD
QKTTLLHFLV EICEENYRDI LKFTDELEHV ESASKVSAQS LKSNLDSMEL QIHRLASDIE
SFPKTEDAHD KFVEKMTISF FAQDQYEKLS NMHNNMTKLY ENLGEYFTFD PKATTIEEFF
GDLSNFRTMF LEALKENNKR REMEEKTKRA RLAKEKAERE RLERQQKKKQ LIDMNKEGDE
TGVMDNLLEA LQSGAAFRDR RKRTPRMQGG CLITALIAPE RTELQGLDM
//
