ID A0A452H433_9SAUR Unreviewed; 285 AA.
AC A0A452H433;
DT 08-MAY-2019, integrated into UniProtKB/TrEMBL.
DT 08-MAY-2019, sequence version 1.
DT 27-MAR-2024, entry version 20.
DE RecName: Full=Interleukin-18 {ECO:0008006|Google:ProtNLM};
OS Gopherus agassizii (Agassiz's desert tortoise).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Testudinata; Testudines; Cryptodira; Durocryptodira;
OC Testudinoidea; Testudinidae; Gopherus.
OX NCBI_TaxID=38772 {ECO:0000313|Ensembl:ENSGAGP00000009410.1, ECO:0000313|Proteomes:UP000291020};
RN [1] {ECO:0000313|Proteomes:UP000291020}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=28562605;
RA Tollis M., DeNardo D.F., Cornelius J.A., Dolby G.A., Edwards T.,
RA Henen B.T., Karl A.E., Murphy R.W., Kusumi K.;
RT "The Agassiz's desert tortoise genome provides a resource for the
RT conservation of a threatened species.";
RL PLoS ONE 12:e0177708-e0177708(2017).
RN [2] {ECO:0000313|Ensembl:ENSGAGP00000009410.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|ARBA:ARBA00004613}.
CC -!- SIMILARITY: Belongs to the IL-1 family.
CC {ECO:0000256|ARBA:ARBA00010448}.
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DR AlphaFoldDB; A0A452H433; -.
DR STRING; 38772.ENSGAGP00000009410; -.
DR Ensembl; ENSGAGT00000010812.1; ENSGAGP00000009410.1; ENSGAGG00000007447.1.
DR Proteomes; UP000291020; Unassembled WGS sequence.
DR GO; GO:0005615; C:extracellular space; IEA:InterPro.
DR GO; GO:0005125; F:cytokine activity; IEA:InterPro.
DR GO; GO:0006955; P:immune response; IEA:InterPro.
DR GO; GO:0006954; P:inflammatory response; IEA:InterPro.
DR Gene3D; 2.80.10.50; -; 1.
DR InterPro; IPR000975; IL-1_fam.
DR InterPro; IPR008996; IL1/FGF.
DR PANTHER; PTHR10078; INTERLEUKIN-1 FAMILY MEMBER; 1.
DR PANTHER; PTHR10078:SF35; INTERLEUKIN-18; 1.
DR Pfam; PF00340; IL1; 1.
DR SUPFAM; SSF50353; Cytokine; 1.
PE 3: Inferred from homology;
KW Reference proteome {ECO:0000313|Proteomes:UP000291020}.
FT REGION 1..62
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 285 AA; 31562 MW; 427A5EABED18CEF4 CRC64;
MQLPSSRNRA GELRAGLASS IAAAKQPKSE SGALQGMGRT PGAGSRAASS PPPAVSMRSA
LPASSRAALP SPPFAAHCAP DSAAGGRVKM SCEEIRVFAV KFGQDFDLYF ADDEGLECDY
WKEVFPLQHQ IFRNVSNQVL VVRLGPENNV MSVFESMTDQ EMIAGCGVHF NIHYYRDNRL
EDGMSVAFSI MVENKTYCMY CTHEGGEKIV RFREEVVPKE ILENSSDIIF IQKSISPRDT
QAFKFESSLM RGYFLAFQKG EDLSKLILKR CDEDQVDETT HIIIP
//
