ID A0A452H6L3_9SAUR Unreviewed; 1760 AA.
AC A0A452H6L3;
DT 08-MAY-2019, integrated into UniProtKB/TrEMBL.
DT 08-MAY-2019, sequence version 1.
DT 24-JAN-2024, entry version 23.
DE SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSGAGP00000010192.1};
OS Gopherus agassizii (Agassiz's desert tortoise).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Testudinata; Testudines; Cryptodira; Durocryptodira;
OC Testudinoidea; Testudinidae; Gopherus.
OX NCBI_TaxID=38772 {ECO:0000313|Ensembl:ENSGAGP00000010192.1, ECO:0000313|Proteomes:UP000291020};
RN [1] {ECO:0000313|Proteomes:UP000291020}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=28562605;
RA Tollis M., DeNardo D.F., Cornelius J.A., Dolby G.A., Edwards T.,
RA Henen B.T., Karl A.E., Murphy R.W., Kusumi K.;
RT "The Agassiz's desert tortoise genome provides a resource for the
RT conservation of a threatened species.";
RL PLoS ONE 12:e0177708-e0177708(2017).
RN [2] {ECO:0000313|Ensembl:ENSGAGP00000010192.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the DOCK family. {ECO:0000256|PROSITE-
CC ProRule:PRU00983}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR Ensembl; ENSGAGT00000011693.1; ENSGAGP00000010192.1; ENSGAGG00000007893.1.
DR Proteomes; UP000291020; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:UniProtKB-KW.
DR GO; GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro.
DR Gene3D; 1.20.58.740; -; 1.
DR Gene3D; 1.25.40.410; -; 1.
DR Gene3D; 2.60.40.150; C2 domain; 1.
DR Gene3D; 1.20.1270.350; Dedicator of cytokinesis N-terminal subdomain; 1.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR027007; C2_DOCK-type_domain.
DR InterPro; IPR035892; C2_domain_sf.
DR InterPro; IPR026791; DOCK.
DR InterPro; IPR043161; DOCK_C_lobe_A.
DR InterPro; IPR043162; DOCK_C_lobe_C.
DR InterPro; IPR032376; DOCK_N.
DR InterPro; IPR042455; DOCK_N_sub1.
DR InterPro; IPR027357; DOCKER_dom.
DR InterPro; IPR046769; DOCKER_Lobe_A.
DR InterPro; IPR046770; DOCKER_Lobe_B.
DR InterPro; IPR046773; DOCKER_Lobe_C.
DR PANTHER; PTHR45653; DEDICATOR OF CYTOKINESIS; 1.
DR PANTHER; PTHR45653:SF6; DEDICATOR OF CYTOKINESIS PROTEIN 2; 1.
DR Pfam; PF06920; DHR-2_Lobe_A; 1.
DR Pfam; PF20422; DHR-2_Lobe_B; 1.
DR Pfam; PF20421; DHR-2_Lobe_C; 1.
DR Pfam; PF14429; DOCK-C2; 1.
DR Pfam; PF16172; DOCK_N; 1.
DR SUPFAM; SSF48371; ARM repeat; 1.
DR PROSITE; PS51650; C2_DOCK; 1.
DR PROSITE; PS51651; DOCKER; 1.
PE 3: Inferred from homology;
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Guanine-nucleotide releasing factor {ECO:0000256|ARBA:ARBA00022658};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP000291020}.
FT DOMAIN 350..534
FT /note="C2 DOCK-type"
FT /evidence="ECO:0000259|PROSITE:PS51650"
FT DOMAIN 1138..1549
FT /note="DOCKER"
FT /evidence="ECO:0000259|PROSITE:PS51651"
FT REGION 1597..1628
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1740..1760
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1760 AA; 204435 MW; 6F116DD8D7A6BA40 CRC64;
KRNTENIVPA EIPLVQEVTT TLWEWESIWK QLYVANKKEQ FQQVQSMMYD LMEWRSQLLS
GTLPKDELKE LKQKVTSKID YGNKILELDL IVRDEDGNIL DPDKTSVISL FHAHEEATDK
ITERIKEEMS KDQPDYGTYS RISSSPTYSL YVFVRNFVCR IGEDAELFMS LYDPQKHTII
SENYLVRWGS KGFPKEIDML NNLKVVFTDL GNKDLNRDKV YLICQIVRVG RMDLKDSNTK
KCTQGLRRPF GVAVMDITDT IKGKAESDEE KQHFIPFHPV MAENDSLHSL LGKVTASKGD
SGGQGLWVTM KMLVGDMSQI RKDYPHLVDR TTVVARKLGF PEIIMPGDIR NDIYVTLTMG
DFDKYNKTTQ RNVEVIMCVC DEEGKVIPNA ICLGAGDKPV SEYRSVLYYQ VKQPRWMETL
KVAVPIEDMQ RIHLRFMFRH RSSQESKDKG EKNFAMAYVK LMKEDGTTLQ DGSHELIVLK
GDSKKMEDAG AYLTLPSCRQ HVENKGLTLS RSASSVGGLS VSTRDAFSIS TLVCSTKLTQ
NVGLLGLLKW RMKPELLQEN LEKLKIVDGE EVVKFLQDTL DALFNIMMEH SHSDEYDILV
FDALIYIIGL IADRKFQHFN TVLEAYIQQH FSATLAYKKL MTVLKTYLDT SSRGEQCEPI
LRTLKALEYV FKFIVRSRTL FSQLYEGKEQ TEFEESMRRL FESINNLMKS QYKTTILLQV
AALKYIPSVL QDVETVFDAK LLSQLLYEFY TCIPPVKLQK QKVQSMNEIV RSNLFKKQEC
RDILLPVITK ELKELLEQRE EQQLQLQEKK YCVELLNSIL EVLSYQDAES TYHHIQELMV
QLLRTVNRTV ISMGRDDTLI SHFVACMTAI LNQMDNQHYS FYIETFQTNS ELVDFLMETF
IMFKDLIGKN VYPSDWMAMS MVQNRVFLRA INKFAETMNQ KFLENMDFEV QLWNNYFHLA
VAFITQDSLQ LEHFSHAKHN KILNKYGDMR RLIGFAIRDM WYKLGQNKIC FIPGMVGPIL
EMTLIPEVEL RKATIPIFFD MMLCEYHKTG EFKKFENEII LNLDHEVEGG RGDEQYMQLF
ESILMECSSA YCDISKTVEN FVNLVKGLLE KLLDYRTVMN DESKDNRMSC TVNLLNFYKD
INREGMYIRY LYKLRDLHLD CENYTEAAYT LLLHTSLLKW SDEQCAPQVM QTEFQYSQTH
RQLKENLYEK IIEYFDKGKM WEESISLCKE LAEQYEMEVF DYELLSQNLI QQAKFYENIM
KILRPKPDYF AVGYYGQGFP TFLRNKVFIY RGKEYERRED FQAQLMSQFP NAEKMNTTSA
PGEDMKNSPG QYIQCFTVQP VLEEHTRFKN KPVPDQIINF YKSNYVQRFH YSRPVRKGSV
DPENEFASMW IERTSFVTAY KLPGILRWFE VVSMSQAIIS PLENAIETMS MTNEKILMMI
NQYQSDENLP INPLSMLLNG IVDPAVMGGF AKYEKAFFTD EYAKDHLEDQ EKLNRLKDLI
AWQIPFLGAG IKIHEKRVSD NLRPFHDRME ECFKHLKIKV EKQYGVRELP DFDDKRVGRP
RSMLRSYRQM SVISLASMNS DCSTPVKMAS ESFELEVAPR KPAKSESEEN VLQISTQPEV
KLRRSKKRTK RSSVVFADEK TAPELSDMKC LSRKYEFMSD TNLSEHLVAP QKTSVLKQMS
FASRSMPTIP GLTLSVVCTP APDETSASQR LSQQIFPSTS EGDKKTLKKK RVNQFFKTKV
MSGEQKSTPD LGQAAELLLQ
//
