ID A0A452H7L9_9SAUR Unreviewed; 901 AA.
AC A0A452H7L9;
DT 08-MAY-2019, integrated into UniProtKB/TrEMBL.
DT 08-MAY-2019, sequence version 1.
DT 24-JAN-2024, entry version 21.
DE RecName: Full=EGF-like domain-containing protein {ECO:0000259|PROSITE:PS50026};
OS Gopherus agassizii (Agassiz's desert tortoise).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Testudinata; Testudines; Cryptodira; Durocryptodira;
OC Testudinoidea; Testudinidae; Gopherus.
OX NCBI_TaxID=38772 {ECO:0000313|Ensembl:ENSGAGP00000010709.1, ECO:0000313|Proteomes:UP000291020};
RN [1] {ECO:0000313|Proteomes:UP000291020}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=28562605;
RA Tollis M., DeNardo D.F., Cornelius J.A., Dolby G.A., Edwards T.,
RA Henen B.T., Karl A.E., Murphy R.W., Kusumi K.;
RT "The Agassiz's desert tortoise genome provides a resource for the
RT conservation of a threatened species.";
RL PLoS ONE 12:e0177708-e0177708(2017).
RN [2] {ECO:0000313|Ensembl:ENSGAGP00000010709.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00076}.
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DR AlphaFoldDB; A0A452H7L9; -.
DR STRING; 38772.ENSGAGP00000010709; -.
DR Ensembl; ENSGAGT00000012279.1; ENSGAGP00000010709.1; ENSGAGG00000008353.1.
DR Proteomes; UP000291020; Unassembled WGS sequence.
DR GO; GO:0005044; F:scavenger receptor activity; IEA:InterPro.
DR CDD; cd00055; EGF_Lam; 2.
DR Gene3D; 2.10.25.10; Laminin; 1.
DR Gene3D; 2.170.300.10; Tie2 ligand-binding domain superfamily; 3.
DR InterPro; IPR000742; EGF-like_dom.
DR InterPro; IPR009030; Growth_fac_rcpt_cys_sf.
DR InterPro; IPR002049; LE_dom.
DR InterPro; IPR042635; MEGF10/SREC1/2-like.
DR PANTHER; PTHR24043; SCAVENGER RECEPTOR CLASS F; 1.
DR PANTHER; PTHR24043:SF0; SCAVENGER RECEPTOR CLASS F MEMBER 1; 1.
DR Pfam; PF00053; Laminin_EGF; 3.
DR PRINTS; PR00011; EGFLAMININ.
DR SMART; SM00181; EGF; 8.
DR SMART; SM00180; EGF_Lam; 5.
DR SUPFAM; SSF57184; Growth factor receptor domain; 1.
DR PROSITE; PS00022; EGF_1; 4.
DR PROSITE; PS50026; EGF_3; 1.
PE 4: Predicted;
KW Disulfide bond {ECO:0000256|PROSITE-ProRule:PRU00076};
KW EGF-like domain {ECO:0000256|PROSITE-ProRule:PRU00076};
KW Reference proteome {ECO:0000313|Proteomes:UP000291020};
KW Signal {ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..21
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 22..901
FT /note="EGF-like domain-containing protein"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5019003152"
FT DOMAIN 50..89
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT REGION 586..686
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 758..901
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 601..623
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 758..793
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 809..823
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 848..874
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 883..901
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT DISULFID 79..88
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
SQ SEQUENCE 901 AA; 96996 MW; 014B405D9855AF9B CRC64;
MTQLLLILFC LRFWPWIGSS AQELDPNGKN VCKATSLSAG LVCCPGWKQE GKECTAALCE
GEDACKVDEV CVRPGICLCK PGFFGANCNS RCPDQYWGSD CKKSCSCHPN GKCDPVSGQC
ICNANRWGVL CEFPCQCAPH GHCNPDTGAC HCEPGWWGPN CKKQCLCRVT GSHCDSVTGQ
CVCTQGWWGR RCSFRCTCHL SPCAQDSGKC ECRAGFWGPL CQHHCDCLHG NCNRLDGHCS
CNPGYQGRSC GDPCPAGYYG SQCRYSCGHC KRSQPCSPVD GFCLACDSGW NGTLCKKLCT
PGYHGENCAQ VCPSCRKGET CHPETGACLN CDPGKTGPSC EASCPAGTFG DGCWFTCPDC
VNGSCDPVSG ECICQAGYWG ISCNETCPEG FFGANCSSPC QCPRGSCHPH SGDCVLRSKH
QGALIAGILI PLLLLLLCVT CCCCCCGTSQ LDARDRMAVA DGDAVSRMKH HVQGVLANLS
SMLPCLSLSG YKLPRITVSH HDTEIPFNPS FIEPPSAAWA SDSSFSSSFD TDDEGPAYCV
PAREDVPAVA GFELQEGSSK CHEFPDASAF NSEDVSQPFT IPRTSSIARA KRPSVSFAEG
TKFGPQCQSG SMETPNTTRK PKASWGLTKL PSCQHLADPE EGPQQGRSPG DCYENPEPIS
EAEASHRPSP RGTPGGHRTA VSSGRHVAQR VEALEAALNP NTLDVRGKEQ NVTTIYVTVG
TAGKSTKLNE SANGSREGTV QAVLKRLGSF QRVKRAVREE PMVRKSTESI QKPPRRALSP
ERDSRDMFPE PAPPHKESSK MTGLEPCESP ELRTDRHQID VPVKREPLIP TSPILKRLVA
QEGEDGVTGD PKNSESLEEA RNLETDEQAV VEEEPKYENV SPNYYPSDES PAISPNCEAN
T
//
