ID A0A452HCP2_9SAUR Unreviewed; 1027 AA.
AC A0A452HCP2;
DT 08-MAY-2019, integrated into UniProtKB/TrEMBL.
DT 08-MAY-2019, sequence version 1.
DT 27-MAR-2024, entry version 18.
DE RecName: Full=Anoctamin {ECO:0000256|RuleBase:RU280814};
OS Gopherus agassizii (Agassiz's desert tortoise).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Testudinata; Testudines; Cryptodira; Durocryptodira;
OC Testudinoidea; Testudinidae; Gopherus.
OX NCBI_TaxID=38772 {ECO:0000313|Ensembl:ENSGAGP00000012558.1, ECO:0000313|Proteomes:UP000291020};
RN [1] {ECO:0000313|Proteomes:UP000291020}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=28562605;
RA Tollis M., DeNardo D.F., Cornelius J.A., Dolby G.A., Edwards T.,
RA Henen B.T., Karl A.E., Murphy R.W., Kusumi K.;
RT "The Agassiz's desert tortoise genome provides a resource for the
RT conservation of a threatened species.";
RL PLoS ONE 12:e0177708-e0177708(2017).
RN [2] {ECO:0000313|Ensembl:ENSGAGP00000012558.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141,
CC ECO:0000256|RuleBase:RU280814}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141, ECO:0000256|RuleBase:RU280814}.
CC -!- SIMILARITY: Belongs to the anoctamin family.
CC {ECO:0000256|ARBA:ARBA00009671, ECO:0000256|RuleBase:RU280814}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|RuleBase:RU280814}.
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DR AlphaFoldDB; A0A452HCP2; -.
DR Ensembl; ENSGAGT00000014395.1; ENSGAGP00000012558.1; ENSGAGG00000009645.1.
DR Proteomes; UP000291020; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR InterPro; IPR007632; Anoctamin.
DR InterPro; IPR049452; Anoctamin_TM.
DR PANTHER; PTHR12308; ANOCTAMIN; 1.
DR PANTHER; PTHR12308:SF51; ANOCTAMIN-8; 1.
DR Pfam; PF04547; Anoctamin; 1.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU280814};
KW Reference proteome {ECO:0000313|Proteomes:UP000291020};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW ECO:0000256|RuleBase:RU280814};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|RuleBase:RU280814}.
FT TRANSMEM 198..220
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU280814"
FT TRANSMEM 232..249
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU280814"
FT TRANSMEM 303..326
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU280814"
FT TRANSMEM 387..410
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU280814"
FT DOMAIN 187..791
FT /note="Anoctamin transmembrane"
FT /evidence="ECO:0000259|Pfam:PF04547"
FT REGION 471..527
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 607..642
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 801..883
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 900..1027
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 474..488
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 607..632
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 801..858
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 900..922
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 970..985
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1006..1027
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1027 AA; 116624 MW; 9A30F62C6C84D577 CRC64;
MSHKSWMKTV PTENCDVLMT FADTTDDHTL LWLLNHIRLG IPELIIQIRH HRHTKVYAFF
VTATYESLLR GADEIGLRKP VKAEFGGGTR SFSCEEDYIY ENIENELFFF TSQERQNIIR
YWLENLRAKH GESLHNIQFL EGQPVIPELV ARGVIQQVFP VHEQRILNRL MKSWVQAICE
AQPLDEICDY FGVKIAMYFA WLGFYTSAMV YPAVFGSILY TFSENDQTSR DICCVVFAIF
NVIWATLFLE EWKQRGAEFA YKWGTLDTPA ESIEEPRPQF RGLKRISPVT NVEEFYYPPW
KRLLFQCLVS LPVCLICLSF VFFVMLGCFE LQEFVLSIKE LPRLIRFLPK IALALIVTAC
DDVYRKIAYW LNDMENYRLQ SAYEKHLIIK IVLFQFVNSY LSLFYIGFYL KDMERLKEML
ATLLITRQFL QNIKEVSQPH LYRKIQRGDL SLQNIRDISH TIFRLLAQRY TAPRPGPEPR
PAEQPARPGP EPEGAGKGPQ GEKCLNGGCG VPEEEEKQES DSEDESVLDC GLKLKKVSFI
ERAERRGREL GAMEDASFLE EGSPTMVEKG MDPASVFELA EDEEESDGPS GSPLPEAKEL
AVTLRARRGR VAESQEEEEE EEGRKRNRAS WIDPPEENYS PHLTQAEVES CMKKYEDTFQ
DYQEMFIQFG YVVLFSSAFP LAALCALINN IIEIHSDAFK LCTGLQRPFG QRVESIGQWQ
KVMEAMGVLA IVVNCYLIGQ CGQLQRLFPW LSPEGAIISV VVLEHFALLL KYLIQVAIPD
IPAWVAEEMA KLEYQRREAF KKHERQAQHH YQQQQRRKRE EEERQRQAEY HARKERETSR
DEGKPEAAGQ DPGHEKSQAK IKGPSGLSHS SEKPKRPSSL LATNNVMKLK QIIPLQSKFL
SGGSAGTAST ATAQSPTGSE NKLPGFLSFK FLKSPETKRD GGTEKVQSPT KPFNPGKLFN
FGKSEGAGGS GASGNGTTAS PPQRPAPSSE GGEKQPPSKA HLNGLVDEGG MEEGELRAEE
ESTGHKL
//
