ID A0A452HFB4_9SAUR Unreviewed; 740 AA.
AC A0A452HFB4;
DT 08-MAY-2019, integrated into UniProtKB/TrEMBL.
DT 08-MAY-2019, sequence version 1.
DT 27-MAR-2024, entry version 23.
DE RecName: Full=SEFIR domain-containing protein {ECO:0000259|PROSITE:PS51534};
OS Gopherus agassizii (Agassiz's desert tortoise).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Testudinata; Testudines; Cryptodira; Durocryptodira;
OC Testudinoidea; Testudinidae; Gopherus.
OX NCBI_TaxID=38772 {ECO:0000313|Ensembl:ENSGAGP00000013518.1, ECO:0000313|Proteomes:UP000291020};
RN [1] {ECO:0000313|Proteomes:UP000291020}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=28562605;
RA Tollis M., DeNardo D.F., Cornelius J.A., Dolby G.A., Edwards T.,
RA Henen B.T., Karl A.E., Murphy R.W., Kusumi K.;
RT "The Agassiz's desert tortoise genome provides a resource for the
RT conservation of a threatened species.";
RL PLoS ONE 12:e0177708-e0177708(2017).
RN [2] {ECO:0000313|Ensembl:ENSGAGP00000013518.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004479}; Single-
CC pass type I membrane protein {ECO:0000256|ARBA:ARBA00004479}.
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DR AlphaFoldDB; A0A452HFB4; -.
DR STRING; 38772.ENSGAGP00000013518; -.
DR Ensembl; ENSGAGT00000015475.1; ENSGAGP00000013518.1; ENSGAGG00000010327.1.
DR Proteomes; UP000291020; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0030368; F:interleukin-17 receptor activity; IEA:InterPro.
DR Gene3D; 3.40.50.11530; -; 1.
DR InterPro; IPR039465; IL-17_rcpt-like.
DR InterPro; IPR031951; IL17R_D_N.
DR InterPro; IPR013568; SEFIR_dom.
DR InterPro; IPR035897; Toll_tir_struct_dom_sf.
DR PANTHER; PTHR15583; INTERLEUKIN-17 RECEPTOR; 1.
DR PANTHER; PTHR15583:SF14; INTERLEUKIN-17 RECEPTOR D; 1.
DR Pfam; PF16742; IL17R_D_N; 1.
DR Pfam; PF08357; SEFIR; 1.
DR SUPFAM; SSF52200; Toll/Interleukin receptor TIR domain; 1.
DR PROSITE; PS51534; SEFIR; 1.
PE 4: Predicted;
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Membrane {ECO:0000256|ARBA:ARBA00023136};
KW Reference proteome {ECO:0000313|Proteomes:UP000291020};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989}.
FT SIGNAL 1..17
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 18..740
FT /note="SEFIR domain-containing protein"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5019373300"
FT DOMAIN 357..510
FT /note="SEFIR"
FT /evidence="ECO:0000259|PROSITE:PS51534"
FT REGION 686..706
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 686..704
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 740 AA; 83988 MW; 7CC987EEC077313D CRC64;
MAPWLQFSSF FFTLVACFKG HQLAGAAGGP SSRRGPAADT CGWRVLPPVS KNGGMLNITF
KYDNCTPYLN SLGKHMIGDV QNITISQYAC SEQVAVTIIW TANVLGIEFL KGFRVILEEL
KSEGRQCQQM VLKDPKQLNS DFKRTGMESQ PFLNLKFETD YFVKIVPFPS IKNESNYHPF
FFRTRPCELL LQPENLACKP FWKPRNLNIT QQGFNMQVSF DHAPHNFGFK YYYLHYKLKD
EGSFKQKTCR QEQNTDITIC VLQNIAPGDY IIELVDDTNT TRKTMHYALK PVHSPWAGPI
RAIAITVPLV VISAFATLFT VMCRKKQQEN IYSHLDEESS ESSTYAAALH VERLRPRPKV
FICYSSKDCQ KHINVIQCFA YFLQDFCGCE VALDIWEDLK NSKEGQKEWL IQKINESQFI
IIVCSKGMKY FVEKKNWKHK GATRDAEKGE LFLLAISIIA EKLRQAKQNS DDLCKFIAVY
FDYSCEGDIP GIVDLSTKYK LMDNLPQLYS HLHSRDLSLQ DSELYPVNIS KRNYFRSKTG
RSLYVAICNM HQFIEQEPDW FEKQLIPFPQ PPLHYQEPVM EKFDSGLVLN DLVSKQVTDG
DFYLKTDVNI IPAVNSDSHC IIQHFNLGED AETQDIQVGS SVLQPLLHVV KAANLPDMPR
DSGIYDSSVP SSELSLPLME GLLTDQTETS SITESVSSSS GLGEEEPPVL TATKCLVPGI
CKAELHCHIH TDELQAIAPL
//
