ID A0A452HFR5_9SAUR Unreviewed; 917 AA.
AC A0A452HFR5;
DT 08-MAY-2019, integrated into UniProtKB/TrEMBL.
DT 08-MAY-2019, sequence version 1.
DT 27-MAR-2024, entry version 23.
DE RecName: Full=Histone deacetylase domain-containing protein {ECO:0000259|Pfam:PF00850};
OS Gopherus agassizii (Agassiz's desert tortoise).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Testudinata; Testudines; Cryptodira; Durocryptodira;
OC Testudinoidea; Testudinidae; Gopherus.
OX NCBI_TaxID=38772 {ECO:0000313|Ensembl:ENSGAGP00000013648.1, ECO:0000313|Proteomes:UP000291020};
RN [1] {ECO:0000313|Proteomes:UP000291020}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=28562605;
RA Tollis M., DeNardo D.F., Cornelius J.A., Dolby G.A., Edwards T.,
RA Henen B.T., Karl A.E., Murphy R.W., Kusumi K.;
RT "The Agassiz's desert tortoise genome provides a resource for the
RT conservation of a threatened species.";
RL PLoS ONE 12:e0177708-e0177708(2017).
RN [2] {ECO:0000313|Ensembl:ENSGAGP00000013648.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR Ensembl; ENSGAGT00000015619.1; ENSGAGP00000013648.1; ENSGAGG00000008155.1.
DR Proteomes; UP000291020; Unassembled WGS sequence.
DR GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.
DR Gene3D; 3.40.800.20; Histone deacetylase domain; 3.
DR InterPro; IPR000286; His_deacetylse.
DR InterPro; IPR023801; His_deacetylse_dom.
DR InterPro; IPR037138; His_deacetylse_dom_sf.
DR InterPro; IPR023696; Ureohydrolase_dom_sf.
DR PANTHER; PTHR10625:SF22; HISTONE DEACETYLASE 6; 1.
DR PANTHER; PTHR10625; HISTONE DEACETYLASE HDAC1-RELATED; 1.
DR Pfam; PF00850; Hist_deacetyl; 3.
DR PRINTS; PR01270; HDASUPER.
DR SUPFAM; SSF52768; Arginase/deacetylase; 2.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000291020}.
FT DOMAIN 115..409
FT /note="Histone deacetylase"
FT /evidence="ECO:0000259|Pfam:PF00850"
FT DOMAIN 477..612
FT /note="Histone deacetylase"
FT /evidence="ECO:0000259|Pfam:PF00850"
FT DOMAIN 627..761
FT /note="Histone deacetylase"
FT /evidence="ECO:0000259|Pfam:PF00850"
FT REGION 42..68
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 422..454
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 835..917
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 917 AA; 100048 MW; EE091256660F3912 CRC64;
MGGDVPGSGX AWQWPRGGCW GWGCLCNPPR FFPFSAPCSF QKRGGRRGPQ PRRSLGLPET
KRRGRAQRMN KDMEELESGL QRLDLSVEGA VPVGTGLAFD EQLMEFHCLW DDSFPECPER
LAAVKGKLLQ CGLWERCVPP GLRVGSEELS LSQEYVELMK STELMSEQEL RALSETYDSV
FLHPGSYRGA RLAGGCVLRL LEKVQDGELR NGLALVRPPG HHAHRDKMDG YCMFNHLAIG
ARYARQKLGV ERVLIVDWDV HHGQGTQFLF EEDPSVLYFS VHRYEQGRFW PHLPASDSPA
VGQGRGEGFN INVPWNAVGM RDGDYLAAFL HVLLPVAFEF QPQLVLVAAG FDSVLGDPKV
RGEMAASAAC FAHLTHLLMA LAGGRVLLSL EGGYNLSSLA EGVCAALRTL LGDPCPRLEP
PVAPCQADIP PEDVEEEPAP TTLPDSPEVP RPLPAARTGL VYDERMTEHY NMWDSQHPEL
PQRVSRIFQR HGELRLTERC HRIPARRAEE EELRMCHSPA YVQTVKATSS MKPRELHRQG
DQYNSIYICA SSYECARLAA GSAFNAVQAV LEGEVQNAVA IVRPPGHHAE SDTACGFCFF
NSVALAARFA QRLAGRPLSG INTPGPPSVL YVSLHRYDHG SFFPTSEDAD ADRVGEGPGR
GFTLNVPWNS PRMGDAEYLA AFHRLVLPVA YQFAPELVLV SAGFDAARGD PLGGCLVSPE
GYAHMTHLLL GLAGGRVVLV LEGGYNLVSI SESMTMCTRT LLGDPLPELG RLRGPHPSAL
QSLARASAEH RKYWACLRLD GKLPGPACRG RAPPAPRPCP LPRGAALHHL HLMQCQSGRT
RGPDPGSRAP SRRTPHQRIP LGGPRVGADS GSPQLSPDSA LVGRASPGGA EPPAAEESEV
GRWRGGDLLW GGWSAWD
//
