ID A0A452HL55_9SAUR Unreviewed; 1122 AA.
AC A0A452HL55;
DT 08-MAY-2019, integrated into UniProtKB/TrEMBL.
DT 08-MAY-2019, sequence version 1.
DT 27-MAR-2024, entry version 22.
DE RecName: Full=protein-tyrosine-phosphatase {ECO:0000256|ARBA:ARBA00013064};
DE EC=3.1.3.48 {ECO:0000256|ARBA:ARBA00013064};
OS Gopherus agassizii (Agassiz's desert tortoise).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Testudinata; Testudines; Cryptodira; Durocryptodira;
OC Testudinoidea; Testudinidae; Gopherus.
OX NCBI_TaxID=38772 {ECO:0000313|Ensembl:ENSGAGP00000015666.1, ECO:0000313|Proteomes:UP000291020};
RN [1] {ECO:0000313|Proteomes:UP000291020}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=28562605;
RA Tollis M., DeNardo D.F., Cornelius J.A., Dolby G.A., Edwards T.,
RA Henen B.T., Karl A.E., Murphy R.W., Kusumi K.;
RT "The Agassiz's desert tortoise genome provides a resource for the
RT conservation of a threatened species.";
RL PLoS ONE 12:e0177708-e0177708(2017).
RN [2] {ECO:0000313|Ensembl:ENSGAGP00000015666.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=H2O + O-phospho-L-tyrosyl-[protein] = L-tyrosyl-[protein] +
CC phosphate; Xref=Rhea:RHEA:10684, Rhea:RHEA-COMP:10136, Rhea:RHEA-
CC COMP:10137, ChEBI:CHEBI:15377, ChEBI:CHEBI:43474, ChEBI:CHEBI:46858,
CC ChEBI:CHEBI:82620; EC=3.1.3.48;
CC Evidence={ECO:0000256|ARBA:ARBA00001490};
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DR Ensembl; ENSGAGT00000017894.1; ENSGAGP00000015666.1; ENSGAGG00000011789.1.
DR Ensembl; ENSGAGT00000017895.1; ENSGAGP00000015667.1; ENSGAGG00000011789.1.
DR Proteomes; UP000291020; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0004725; F:protein tyrosine phosphatase activity; IEA:UniProtKB-EC.
DR GO; GO:0016311; P:dephosphorylation; IEA:InterPro.
DR CDD; cd00063; FN3; 2.
DR CDD; cd14614; R-PTPc-O; 1.
DR Gene3D; 2.60.40.10; Immunoglobulins; 3.
DR Gene3D; 3.90.190.10; Protein tyrosine phosphatase superfamily; 1.
DR InterPro; IPR003961; FN3_dom.
DR InterPro; IPR036116; FN3_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR029021; Prot-tyrosine_phosphatase-like.
DR InterPro; IPR000242; PTP_cat.
DR InterPro; IPR042996; PTPRO.
DR InterPro; IPR016130; Tyr_Pase_AS.
DR InterPro; IPR003595; Tyr_Pase_cat.
DR InterPro; IPR000387; Tyr_Pase_dom.
DR PANTHER; PTHR47028; RECEPTOR-TYPE TYROSINE-PROTEIN PHOSPHATASE O; 1.
DR PANTHER; PTHR47028:SF1; RECEPTOR-TYPE TYROSINE-PROTEIN PHOSPHATASE O; 1.
DR Pfam; PF00041; fn3; 2.
DR Pfam; PF00102; Y_phosphatase; 1.
DR PRINTS; PR00700; PRTYPHPHTASE.
DR SMART; SM00060; FN3; 5.
DR SMART; SM00194; PTPc; 1.
DR SMART; SM00404; PTPc_motif; 1.
DR SUPFAM; SSF52799; (Phosphotyrosine protein) phosphatases II; 1.
DR SUPFAM; SSF49265; Fibronectin type III; 3.
DR PROSITE; PS50853; FN3; 4.
DR PROSITE; PS00383; TYR_PHOSPHATASE_1; 1.
DR PROSITE; PS50056; TYR_PHOSPHATASE_2; 1.
DR PROSITE; PS50055; TYR_PHOSPHATASE_PTP; 1.
PE 4: Predicted;
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Protein phosphatase {ECO:0000256|ARBA:ARBA00022912};
KW Reference proteome {ECO:0000313|Proteomes:UP000291020};
KW Signal {ECO:0000256|ARBA:ARBA00022729};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 726..750
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 786..807
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 234..330
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 340..437
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 537..630
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 631..723
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 844..1101
FT /note="Tyrosine-protein phosphatase"
FT /evidence="ECO:0000259|PROSITE:PS50055"
FT DOMAIN 1018..1092
FT /note="Tyrosine specific protein phosphatases"
FT /evidence="ECO:0000259|PROSITE:PS50056"
SQ SEQUENCE 1122 AA; 127586 MW; 19631930D777E5EF CRC64;
MVVNSNMVSK PVRSITVLTK PLPISSVSIY DYKPSPETGV LFEIQYPEKY NVFTRVNISY
WEGKDYRTML YKDFFKGKTV FNHWLPGICY SNITFQLVSE ATFNKSTLVE YSGVRHEPKQ
HRTVPYPPRN ISVQIVHMNK NNWEEHSGNF LEESFMGPQD VIGQDKLIHF SNGPTEIPSA
NTSDAWPDYH YNSTDYTTTT QPYWWTNEAD SSESEDEFVN VVPSEYENSS TASMSGKLTP
ETPSFLPVQM VLSWLPPKPP TAFDGFHINI EREEKTTEFL TVGEDTHEFI AELKEPGKYK
LSVTTFSSSG SCEIRRSQSA KTLSFYISPT GEWIEELTEK PQHVSVTVLS STTALMSWTS
SQDSSSNNTI VSVVSLTCQK QKESQRLEKH YCTEVNSSNS IIENLVPGAQ YQVVIYLRKG
PLVGPPSDPV TFAIVPTGIK DLMLYPLGPT AVILSWNRPY LGVFRKYVVE MFYFNPSTMT
SEWMTYYEIA ATVSLTASVK IANLLPAWYY NFRVTMVTWG DPELSCCDSS TISYITAPVS
PEITSVEYFN NLLYVSWTYG DNGTDLSHSR MLHWMIIAEG KKKIKKSVTR NVMTTVLSLP
PGDIYNLSVT ACTERGSNAS TPQIVKLEPA PPKSLFAVNK TQTSVTLLWV EEGVADFFEV
FCQQAGSGQE TKLQEPVTVS SHVVTISSLL PATSYNCSVI TFSHNSPSVP TFIAVSTMVT
EMNPNIVVIS VLAILSILLI GLLLVTLVVL RRKHLQMARE CGAGTFVNFA SLERDGKLPY
NWRRSVFAFL TLLPSCLWTD YLLAFYINPW SKNGLKKRKL TNPVQLDDFD GYIKDMAKDS
DYKFSLQFEE LKLIGLDIPH FAADLPMNRC KNRYTNILPY DFSRVRLVSM NEEEGSDYIN
ANYIPGYNSP QEYIATQGPL PETRNDFWKM VLQQKSQIIV MLTQCNEKRR VKCDHYWPFT
EEPVAYGDIT VEMLSEEEQM DWSYRNFRIS YADEVQDVMH FNYTAWPDHG VPTTNAAESI
LQFVQMVRQQ SAKSKGPMVI HCSAGVGRTG TFIALDRLLQ HIRDHEFVDI LGLVSDMRSY
RMSMVQTEEQ YIFIHQCVQL MWLKKKQQFC ISDVIYENVS KS
//
