ID   A0A452HLC5_9SAUR        Unreviewed;       708 AA.
AC   A0A452HLC5;
DT   08-MAY-2019, integrated into UniProtKB/TrEMBL.
DT   08-MAY-2019, sequence version 1.
DT   24-JAN-2024, entry version 20.
DE   RecName: Full=C2 DOCK-type domain-containing protein {ECO:0000259|PROSITE:PS51650};
OS   Gopherus agassizii (Agassiz's desert tortoise).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Archelosauria; Testudinata; Testudines; Cryptodira; Durocryptodira;
OC   Testudinoidea; Testudinidae; Gopherus.
OX   NCBI_TaxID=38772 {ECO:0000313|Ensembl:ENSGAGP00000015739.1, ECO:0000313|Proteomes:UP000291020};
RN   [1] {ECO:0000313|Proteomes:UP000291020}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=28562605;
RA   Tollis M., DeNardo D.F., Cornelius J.A., Dolby G.A., Edwards T.,
RA   Henen B.T., Karl A.E., Murphy R.W., Kusumi K.;
RT   "The Agassiz's desert tortoise genome provides a resource for the
RT   conservation of a threatened species.";
RL   PLoS ONE 12:e0177708-e0177708(2017).
RN   [2] {ECO:0000313|Ensembl:ENSGAGP00000015739.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2023) to UniProtKB.
CC   -!- SIMILARITY: Belongs to the DOCK family. {ECO:0000256|PROSITE-
CC       ProRule:PRU00983}.
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DR   AlphaFoldDB; A0A452HLC5; -.
DR   Ensembl; ENSGAGT00000017969.1; ENSGAGP00000015739.1; ENSGAGG00000011372.1.
DR   Proteomes; UP000291020; Unassembled WGS sequence.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR   GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:InterPro.
DR   GO; GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro.
DR   CDD; cd08694; C2_Dock-A; 1.
DR   Gene3D; 2.60.40.150; C2 domain; 1.
DR   Gene3D; 1.20.1270.350; Dedicator of cytokinesis N-terminal subdomain; 1.
DR   InterPro; IPR027007; C2_DOCK-type_domain.
DR   InterPro; IPR035892; C2_domain_sf.
DR   InterPro; IPR026791; DOCK.
DR   InterPro; IPR047026; DOCK1_C2.
DR   InterPro; IPR032376; DOCK_N.
DR   InterPro; IPR042455; DOCK_N_sub1.
DR   PANTHER; PTHR45653; DEDICATOR OF CYTOKINESIS; 1.
DR   PANTHER; PTHR45653:SF1; DEDICATOR OF CYTOKINESIS PROTEIN 1; 1.
DR   Pfam; PF14429; DOCK-C2; 1.
DR   Pfam; PF16172; DOCK_N; 1.
DR   PROSITE; PS51650; C2_DOCK; 1.
PE   3: Inferred from homology;
KW   Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW   Reference proteome {ECO:0000313|Proteomes:UP000291020}.
FT   DOMAIN          375..559
FT                   /note="C2 DOCK-type"
FT                   /evidence="ECO:0000259|PROSITE:PS51650"
SQ   SEQUENCE   708 AA;  80527 MW;  A7711F5EA6F30F9F CRC64;
     RPVGAAGSGG QYVPQPAPLP AAPIGLEQRT AASRIIPSEL PLIQEVTTTL REWSIIWRQL
     YVVSKIHMFH SVRHMIYDLI EWRSQILSGT LPQDELKELK KKVTAKIDYG NRILDLDLVV
     RDEDGNILDP EQTSTISLFR AHEIASKQVE ERLLEEKVRY TIPNSKFAAT PSFALFVNLK
     NVVCKIGEDA EVLMSLYDPL ESKFISENYL VRWSSSGLPK DIDRLHNLRA VFTDLGSKDL
     KREKISFVCQ IVRVGRMELR DNNTRKLTSG LRRPFGVAVM DVTDIINGKV DDEDKQHFIP
     FQPVAGENDF LQTVINKVIA AKEVNHKGQG LWVTLKLLPG DIHQIRKEFP HLVDRSTAVA
     RKMGFPEIIM PGDVRNDIYV TLVQGDFDKG SKTTAKNVEV TVSVYDEDGK RLENVIFPGA
     GDDAISEYKS VIYYQVKQPR WFETVKVAIP IEDVNRSHLR FTFRHRSSQD SKDKSEKIFA
     LAFVKLMRYD GTTLRDGEHD LIVYKAEAKK LEDASTYLSL PSTKIELEEK GHATTGKSMQ
     NLGSCTISKD SFQISTLVCS TKLTQNVDLL GLLKWRSNTN LLQQNLRQLM KVDGGEVVKF
     LQDTLDALFN IMMENSESET FDTLVFDALV FIIGLIADRK FQHFNPVLET YIKKHFSATL
     AYTKLTKVLR NYVDNAEKPG VTDQLFKAMK ALEYIFKFIV RSRILFNQ
//